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Pracytarabine

Tier C — Watch / trade

Pracytarabine

Ligand Pharmaceuticals Inc
Originator
-
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets:DNA-directed DNA polymerase

Indications (approved):Liver cancer, Hepatocellular carcinoma, 线粒体疾病, Cholangiocarcinoma

Regional status

US
No progress
2003-09-01
EU
-
China
Phase III
2025-09-01
Japan
-

Synthetic routes & intermediates2 routes

Originator routes × 1Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 5 · Total yield 2.55 g
MB07133-008—MB07133-001591228-11-4MB07133-00217469-89-5MB07133-0031026885-94-8MB07133-004685111-87-9MB07133-005777-52-6MB07133-0061192264-91-7MB07133-007685111-91-5API · Pracytarabine
CodeCAS No.Intermediate
MB07133-008-(E)-N'-(1-((2R,3S,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-((((2R,4S)-2-oxido-4-(pyridin-4-yl)-1,3,2-dioxaphosphinan-2-yl)oxy)methyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-N,N-dimethylformimidamide
MB07133-001591228-11-4ethyl 3-hydroxy-3-(pyridin-4-yl)propanoate
MB07133-00217469-89-5N,N-dimethyl-L-phenylalanine
MB07133-0031026885-94-8(S)-3-ethoxy-3-oxo-1-(pyridin-4-yl)propyl dimethyl-L-phenylalaninate
MB07133-004685111-87-9(S)-1-(pyridin-4-yl)propane-1,3-diol
MB07133-005777-52-6Available4-nitrophenyl phosphorodichloridate
MB07133-0061192264-91-7(2S,4S)-2-(4-nitrophenoxy)-4-(pyridin-4-yl)-1,3,2-dioxaphosphinane 2-oxide
MB07133-007685111-91-5(E)-N'-(1-((2R,3S,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-N,N-dimethylformimidamide
OptimisedRoute 2Steps 2 · Total yield 1.38 g
MB07133-004685111-87-9MB07133-009685111-93-7MB07133-010147-94-4API · Pracytarabine
CodeCAS No.Intermediate
MB07133-004685111-87-9(S)-1-(pyridin-4-yl)propane-1,3-diol
MB07133-009685111-93-7(2S,4S)-2-chloro-4-(pyridin-4-yl)-1,3,2-dioxaphosphinane 2-oxide
MB07133-010147-94-44-amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

Frequently asked questions

What are the approved indications of Pracytarabine?

Approved indications include: Liver cancer, Hepatocellular carcinoma, 线粒体疾病, Cholangiocarcinoma.

When does the Pracytarabine patent expire?

No public expiry year is available for Pracytarabine yet; this page updates once verified.

How many synthesis routes are recorded for Pracytarabine?

2 synthesis routes are recorded; the shortest is 2 steps with 1.38 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Pracytarabine intermediates?

1 intermediate CAS of Pracytarabine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Pracytarabine intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-30