← Back to patent-cliff list
Fimasartan potassium trihydrate/Rosuvastatin calcium
Tier C — Watch / tradeFimasartan potassium trihydrate/Rosuvastatin calcium
Boryung Pharmaceutical Co., Ltd.
Originator
2016
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：AT1, HMGCR
Brand：Tuvero
Indications (approved)：Hypertension, Dyslipidaemia
Regional status
US
-
EU
-
China
-
Japan
-
Factories producing this API12
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
12 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 3Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 10 · Total yield 162 mg
ROSU-001459-57-4ROSU-0027152-15-0ROSU-003122930-45-4ROSU-004—ROSU-005147118-27-2ROSU-006147118-28-3ROSU-007147118-30-7ROSU-008147118-37-4ROSU-009147118-35-2ROSU-010147118-38-5ROSU-011147118-39-6ROSU-012147118-40-9ROSU-013147098-18-8API · Fimasartan potassium trihydrate/Rosuvastatin calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-001 | 459-57-4 | 4-fluorobenzaldehyde |
| ROSU-002 | 7152-15-0 | ethyl 4-methyl-3-oxopentanoate |
| ROSU-003 | 122930-45-4 | (Z)-ethyl 2-(4-fluorobenzylidene)-4-methyl-3-oxopentanoate |
| ROSU-004 | - | (methyleneamino)(methylthio)methanamine |
| ROSU-005 | 147118-27-2 | ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylthio)pyrimidine-5-carboxylate |
| ROSU-006 | 147118-28-3 | ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate |
| ROSU-007 | 147118-30-7 | ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate |
| ROSU-008 | 147118-37-4 | N-(4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-009 | 147118-35-2 | methyl (R)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenyl-l5-phosphanylidene)hexanoate |
| ROSU-010 | 147118-38-5 | methyl (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-oxohept-6-enoate |
| ROSU-011 | 147118-39-6 | methyl (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate |
| ROSU-012 | 147118-40-9 | methyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate |
| ROSU-013 | 147098-18-8 | sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate |
OptimisedRoute 2Steps 10 · Total yield /
ROSU-014714963-27-6ROSU-015866088-06-4ROSU-016866088-07-5ROSU-017866088-08-6ROSU-018116563-00-9ROSU-019866114-13-8ROSU-020289042-10-0ROSU-021866088-09-7ROSU-022—ROSU-023—ROSU-024503610-43-3API · Fimasartan potassium trihydrate/Rosuvastatin calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-014 | 714963-27-6 | (4R,6S)-6-(chloromethyl)tetrahydro-2H-pyran-2,4-diol |
| ROSU-015 | 866088-06-4 | (2S,4R)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran-4-ol |
| ROSU-016 | 866088-07-5 | (2S,4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran |
| ROSU-017 | 866088-08-6 | ((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methyl acetate |
| ROSU-018 | 116563-00-9 | ((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methanol |
| ROSU-019 | 866114-13-8 | (2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-carbaldehyde |
| ROSU-020 | 289042-10-0 | N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-021 | 866088-09-7 | N-(5-((E)-2-((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-022 | - | N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-methoxytetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-023 | - | N-(5-((E)-2-((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-024 | 503610-43-3 | N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
OptimisedRoute 3Steps 12 · Total yield 50 g
ROSU-008147118-37-4ROSU-013147098-18-8ROSU-025141942-85-0ROSU-026141942-82-7ROSU-027105876-28-6ROSU-0281644395-21-0ROSU-0291644395-22-1ROSU-030908274-86-2ROSU-03179-22-1ROSU-032908274-87-3ROSU-0331779-49-3ROSU-034908274-88-4ROSU-035676256-39-6ROSU-036615556-96-2ROSU-037355806-00-7API · Fimasartan potassium trihydrate/Rosuvastatin calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-008 | 147118-37-4 | N-(4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-013 | 147098-18-8 | sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate |
| ROSU-025 | 141942-85-0 | ethyl (R)-4-cyano-3-hydroxybutanoate |
| ROSU-026 | 141942-82-7 | ethyl (R)-3-((tert-butyldimethylsilyl)oxy)-4-cyanobutanoate |
| ROSU-027 | 105876-28-6 | (R)-3-((tert-butyldimethylsilyl)oxy)-4-cyanobutanoic acid |
| ROSU-028 | 1644395-21-0 | tert-butyl (R)-3-((tert-butyldimethylsilyl)oxy)-4-cyanobutanoate |
| ROSU-029 | 1644395-22-1 | tert-butyl (R)-5-amino-3-((tert-butyldimethylsilyl)oxy)-5-oxopentanoate |
| ROSU-030 | 908274-86-2 | (R)-5-(tert-butoxy)-3-((tert-butyldimethylsilyl)oxy)-5-oxopentanoic acid |
| ROSU-031 | 79-22-1 | methyl carbonochloridate |
| ROSU-032 | 908274-87-3 | (S)-(R)-5-(tert-butoxy)-3-((tert-butyldimethylsilyl)oxy)-5-oxopentanoic (ethyl carbonic) anhydride |
| ROSU-033 | 1779-49-3 | methyltriphenylphosphonium bromide |
| ROSU-034 | 908274-88-4 | tert-butyl (R)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenyl-l5-phosphanylidene)hexanoate |
| ROSU-035 | 676256-39-6 | tert-butyl (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-oxohept-6-enoate |
| ROSU-036 | 615556-96-2 | tert-butyl (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate |
| ROSU-037 | 355806-00-7 | tert-butyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate |
OptimisedRoute 4Steps 7 · Total yield 4.38 g
ROSU-008147118-37-4ROSU-03179-22-1ROSU-0331779-49-3ROSU-03891424-40-7ROSU-0393886-69-9ROSU-040121331-25-7ROSU-04191424-38-3ROSU-0421360110-92-4ROSU-0431360110-94-6ROSU-0441456783-25-7ROSU-0451456783-26-8API · Fimasartan potassium trihydrate/Rosuvastatin calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-008 | 147118-37-4 | N-(4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-031 | 79-22-1 | methyl carbonochloridate |
| ROSU-033 | 1779-49-3 | methyltriphenylphosphonium bromide |
| ROSU-038 | 91424-40-7 | 4-((tert-butyldimethylsilyl)oxy)dihydro-2H-pyran-2,6(3H)-dione |
| ROSU-039 | 3886-69-9Available | (R)-1-phenylethan-1-amine |
| ROSU-040 | 121331-25-7 | (S)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-5-(((R)-1-phenylethyl)amino)pentanoic acid |
| ROSU-041 | 91424-38-3 | (S)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-5-(((R)-1-phenylethyl)amino)pentanoic (methyl carbonic) anhydride |
| ROSU-042 | 1360110-92-4 | (R)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-N-((R)-1-phenylethyl)-6-(triphenyl-l5-phosphanylidene)hexanamide |
| ROSU-043 | 1360110-94-6 | (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-oxo-N-((R)-1-phenylethyl)hept-6-enamide |
| ROSU-044 | 1456783-25-7 | (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxo-N-((R)-1-phenylethyl)hept-6-enamide |
| ROSU-045 | 1456783-26-8 | (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxy-N-((R)-1-phenylethyl)hept-6-enamide |
ProcessRoute 5Steps 8 · Total yield 1.67 kg
ROSU-001459-57-4ROSU-020289042-10-0ROSU-024503610-43-3ROSU-04642558-54-3ROSU-04757-13-6ROSU-048488798-36-3ROSU-049488798-37-4ROSU-0501184-85-6ROSU-051289042-11-1ROSU-052147118-36-3ROSU-053799842-07-2ROSU-055172405-02-6ROSU-056—API · Fimasartan potassium trihydrate/Rosuvastatin calcium
| Code | CAS No. | Intermediate |
|---|---|---|
| ROSU-001 | 459-57-4 | 4-fluorobenzaldehyde |
| ROSU-020 | 289042-10-0 | N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-024 | 503610-43-3 | N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-046 | 42558-54-3 | methyl 4-methyl-3-oxopentanoate |
| ROSU-047 | 57-13-6 | urea |
| ROSU-048 | 488798-36-3 | methyl 4-(4-fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
| ROSU-049 | 488798-37-4 | methyl 4-(4-fluorophenyl)-2-hydroxy-6-isopropylpyrimidine-5-carboxylate |
| ROSU-050 | 1184-85-6 | N-methylmethanesulfonamide |
| ROSU-051 | 289042-11-1 | methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate |
| ROSU-052 | 147118-36-3 | N-(4-(4-fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-053 | 799842-07-2 | N-(5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide |
| ROSU-055 | 172405-02-6 | tert-butyl (4S,6S)-6-formyl-2,2-dimethyl-1,3-dioxane-4-carboxylate |
| ROSU-056 | - | tert-butyl (4S,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxane-4-carboxylate |
Frequently asked questions
What are the approved indications of Fimasartan potassium trihydrate/Rosuvastatin calcium?
Approved indications include: Hypertension, Dyslipidaemia.
When does the Fimasartan potassium trihydrate/Rosuvastatin calcium patent expire?
No public expiry year is available for Fimasartan potassium trihydrate/Rosuvastatin calcium yet; this page updates once verified.
How many synthesis routes are recorded for Fimasartan potassium trihydrate/Rosuvastatin calcium?
5 synthesis routes are recorded; the shortest is 7 steps with 4.38 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Fimasartan potassium trihydrate/Rosuvastatin calcium intermediates?
1 intermediate CAS of Fimasartan potassium trihydrate/Rosuvastatin calcium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Fimasartan potassium trihydrate/Rosuvastatin calcium intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29