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Roxithromycin/Ambroxol Hydrochloride
Tier C — Watch / tradeRoxithromycin/Ambroxol Hydrochloride
Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.
Originator
2010
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：50S ribosomal subunit
Indications (approved)：Chronic bronchitis, Bronchitis
Regional status
US
-
EU
-
China
Approved
2010-01-15
Japan
-
Factories producing this API12
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
12 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates12 routes
Originator routes × 0Optimised (non-patent) × 12Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 4 · Total yield 1.29g(Roxithromycin (Free))
Roxithromycin-001114-07-8Roxithromycin-0027704-67-8Roxithromycin-00313127-18-9Roxithromycin-00413127-18-9Roxithromycin-0053970-21-6API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Roxithromycin-001 | 114-07-8 | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione |
| Roxithromycin-002 | 7704-67-8 | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione thiocyanate |
| Roxithromycin-003 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
| Roxithromycin-004 | 13127-18-9 | Thiocyanic acid--(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one (1/1) |
| Roxithromycin-005 | 3970-21-6 | 2-Methoxyethoxymethyl chloride |
OptimisedRoute 1Steps 5 · Total yield 14.7g(Ambroxol)
Ambroxol- 00127489-62-9,50910-54-8Ambroxol- 002118-48-9Ambroxol- 003—Ambroxol- 004—Ambroxol- 005552-89-6Ambroxol- 006—API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Ambroxol- 001 | 27489-62-9,50910-54-8 | trans-4-Aminocyclohexanol |
| Ambroxol- 002 | 118-48-9 | 2,4-Dihydro-1H-3,1-benzoxazine-2,4-dione |
| Ambroxol- 003 | - | trans-2-Amino-N-(4-hydroxycyclohexyl)benzamide |
| Ambroxol- 004 | - | trans-4-(2-Aminobenzylamino)cyclohexanol |
| Ambroxol- 005 | 552-89-6Available | 2-Nitrobenzaldehyde |
| Ambroxol- 006 | - | trans-4-(2-Nitrophenylmethyleneamino)cyclohexanol |
OptimisedRoute 2Steps 3 · Total yield 4.5g(Ambroxol)
Ambroxol- 00750910-55-9Ambroxol- 00850910-53-7Ambroxol- 00127489-62-9,50910-54-8API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Ambroxol- 007 | 50910-55-9 | 2-Amino-3,5-dibromobenzaldehyde |
| Ambroxol- 008 | 50910-53-7 | trans-4-(2-Amino-3,5-dibromobenzylideneamino)cyclohexanol |
| Ambroxol- 001 | 27489-62-9,50910-54-8 | trans-4-Aminocyclohexanol |
OptimisedRoute 3Steps 5 · Total yield 13g(Ambroxol)
Ambroxol- 009592-57-4Ambroxol- 010189081-97-8Ambroxol- 01186379-71-7Ambroxol- 012199472-97-4Ambroxol- 013199473-03-5Ambroxol- 01418683-91-5API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Ambroxol- 009 | 592-57-4 | 1,3-Cyclohexadiene |
| Ambroxol- 010 | 189081-97-8 | (1R,4R)-4-Chlorocyclohex-2-en-1-yl acetate |
| Ambroxol- 011 | 86379-71-7 | 2-(Aminomethyl)-4,6-dibromoaniline |
| Ambroxol- 012 | 199472-97-4 | (1R,4R)-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohex-2-en-1-yl acetate |
| Ambroxol- 013 | 199473-03-5 | (1R,4R)-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohex-2-en-1-ol |
| Ambroxol- 014 | 18683-91-5 | 2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine |
OptimisedRoute 4Steps 2 · Total yield /
Ambroxol- 01562715-80-4Ambroxol- 01627489-62-9,50910-54-8Ambroxol- 017—API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Ambroxol- 015 | 62715-80-4 | N-Acetyl-N-(2,4,6-tribromophenyl)acetamide |
| Ambroxol- 016 | 27489-62-9,50910-54-8 | trans-4-Aminocyclohexanol |
| Ambroxol- 017 | - | N-Acetyl-N-(2,4-dibromo-6-[[(trans-4-hydroxycyclohexyl)amino]methyl]phenyl)acetamide |
OptimisedRoute 5Steps 10 · Total yield 2.345g(Ambroxol)
Ambroxol- 018118-92-3Ambroxol- 019134-20-3Ambroxol- 020606-00-8Ambroxol- 02150739-76-9Ambroxol- 022105735-86-2Ambroxol- 02318683-91-5Ambroxol- 00750910-55-9Ambroxol- 00850910-53-7Ambroxol- 00127489-62-9,50910-54-8API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Ambroxol- 018 | 118-92-3 | Anthranilic acid |
| Ambroxol- 019 | 134-20-3 | Methyl anthranilate |
| Ambroxol- 020 | 606-00-8 | Methyl 2-amino-3,5-dibromobenzoate |
| Ambroxol- 021 | 50739-76-9 | 2-Amino-3,5-dibromobenzyl alcohol |
| Ambroxol- 022 | 105735-86-2 | 2-Amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzamide |
| Ambroxol- 023 | 18683-91-5 | 2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine |
| Ambroxol- 007 | 50910-55-9 | 2-Amino-3,5-dibromobenzaldehyde |
| Ambroxol- 008 | 50910-53-7 | trans-4-(2-Amino-3,5-dibromobenzylideneamino)cyclohexanol |
| Ambroxol- 001 | 27489-62-9,50910-54-8 | trans-4-Aminocyclohexanol |
OptimisedRoute 6Steps 5 · Total yield /
Ambroxol- 02465962-15-4Ambroxol- 0252719820-08-1Ambroxol- 0262719820-10-5Ambroxol- 027529-23-7Ambroxol- 02826908-34-9Ambroxol- 00750910-55-9API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Ambroxol- 024 | 65962-15-4 | 1-(Dibromomethyl)-2-nitrobenzene |
| Ambroxol- 025 | 2719820-08-1 | 2-(Dibromomethyl)aniline |
| Ambroxol- 026 | 2719820-10-5 | 2,4-Dibromo-6-(dibromomethyl)aniline |
| Ambroxol- 027 | 529-23-7 | 2-Aminobenzaldehyde |
| Ambroxol- 028 | 26908-34-9 | 2-(1,3-Dioxolan-2-yl)aniline |
| Ambroxol- 007 | 50910-55-9 | 2-Amino-3,5-dibromobenzaldehyde |
OptimisedRoute 7Steps 5 · Total yield 35.12g(Ambroxol)
Ambroxol- 029861787-48-6Ambroxol- 030—Ambroxol- 0312293093-91-9Ambroxol- 005552-89-6Ambroxol- 00127489-62-9,50910-54-8Ambroxol- 02318683-91-5API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Ambroxol- 029 | 861787-48-6 | 3,5-Dibromo-2-nitrobenzaldehyde |
| Ambroxol- 030 | - | trans-4-(2-Nitro-3,5-dibromobenzylideneamino)cyclohexanol |
| Ambroxol- 031 | 2293093-91-9 | (2-Amino-3,5-dibromophenyl)methyl 1H-imidazole-1-carboxylate |
| Ambroxol- 005 | 552-89-6Available | o-Nitrobenzaldehyde |
| Ambroxol- 001 | 27489-62-9,50910-54-8 | trans-4-Aminocyclohexanol |
| Ambroxol- 023 | 18683-91-5 | 2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine |
OptimisedRoute 8Steps 3 · Total yield 359.2g(Ambroxol)
Ambroxol- 03295-53-4Ambroxol- 033100669-81-6Ambroxol- 00127489-62-9,50910-54-8Ambroxol- 02318683-91-5API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Ambroxol- 032 | 95-53-4 | 2-Methylaniline |
| Ambroxol- 033 | 100669-81-6 | 2,4-Dibromo-6-(bromomethyl)aniline |
| Ambroxol- 001 | 27489-62-9,50910-54-8 | trans-4-Aminocyclohexanol |
| Ambroxol- 023 | 18683-91-5 | 2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine |
OptimisedRoute 9Steps 3 · Total yield 10.9g(Ambroxol- 037)
Ambroxol- 03485-44-9Ambroxol- 03557-13-6Ambroxol- 03685-41-6Ambroxol- 037609-85-8Ambroxol- 018118-92-3API · Roxithromycin/Ambroxol Hydrochloride
OptimisedRoute 10Steps 4 · Total yield 9.16g Ambroxol
Ambroxol- 038—Ambroxol- 022105735-86-2Ambroxol- 02318683-91-5Ambroxol- 00127489-62-9,50910-54-8Ambroxol- 002118-48-9API · Roxithromycin/Ambroxol Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Ambroxol- 038 | - | trans-2-Amino-N-(4-hydroxycyclohexyl)benzamide |
| Ambroxol- 022 | 105735-86-2 | 2-Amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzamide |
| Ambroxol- 023 | 18683-91-5 | 2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine |
| Ambroxol- 001 | 27489-62-9,50910-54-8 | trans-4-Aminocyclohexanol |
| Ambroxol- 002 | 118-48-9 | Anthranilic acid N-carboxylic acid anhydride |
OptimisedRoute 11Steps 4 · Total yield 14g(Ambroxol- 005)
Ambroxol- 03988-72-2Ambroxol- 0403958-60-9Ambroxol- 041612-25-9Ambroxol- 04286073-80-5Ambroxol- 005552-89-6API · Roxithromycin/Ambroxol Hydrochloride
Frequently asked questions
What are the approved indications of Roxithromycin/Ambroxol Hydrochloride?
Approved indications include: Chronic bronchitis, Bronchitis.
When does the Roxithromycin/Ambroxol Hydrochloride patent expire?
No public expiry year is available for Roxithromycin/Ambroxol Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Roxithromycin/Ambroxol Hydrochloride?
12 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Roxithromycin/Ambroxol Hydrochloride intermediates?
2 intermediate CAS of Roxithromycin/Ambroxol Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Roxithromycin/Ambroxol Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29