Canagliflozin/Metformin Hydrochloride
Tier B — Position earlyCanagliflozin/Metformin Hydrochloride · all drugs expiring in 2029 →
Targets：PRKAB1, SGLT2
Brand：Invokamet Xr, Vokanamet, Invokamet
Indications (approved)：End-stage renal disease, Cardiac and vascular disorders, Abdominal aortic aneurysm, Type 2 diabetes
Regional status
Factories producing this API10
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
10 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| CANA-001 | 79669-49-1 | 5-bromo-2-methylbenzoic acid |
| CANA-002 | 21900-41-4 | 5-bromo-2-methylbenzoyl chloride |
| CANA-003 | 58861-48-6Available | 2-(4-fluorophenyl)thiophene |
| CANA-004 | 1132832-75-7 | (5-bromo-2-methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)methanone |
| CANA-005 | 1030825-20-7Available | 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene |
| CANA-006 | 32384-65-9Available | (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one |
| CANA-007 | 1672658-93-3 | (3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol |
| CANA-008 | 1030825-21-8 | (3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol |
| Code | CAS No. | Intermediate |
|---|---|---|
| CANA-003 | 58861-48-6Available | 2-(4-fluorophenyl)thiophene |
| CANA-009 | 1003-09-4 | 2-bromothiophene |
| CANA-010 | 460-00-4 | 1-bromo-4-fluorobenzene |
| CANA-011 | 108440-70-6 | 5-iodo-2-methylbenzoyl chloride |
| CANA-012 | 898566-17-1Available | 2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene |
| CANA-013 | 61259-48-1 | (2R,3R,4S,5R)-2-(acetoxymethyl)-6-oxotetrahydro-2H-pyran-3,4,5-triyl triacetate |
| CANA-014 | 1071929-02-6 | (3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2-hydroxytetrahydro-2H-pyran-3,4,5-triyl triacetate |
| CANA-015 | 866607-35-4Available | (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate |
| Code | CAS No. | Intermediate |
|---|---|---|
| CANA-012 | 898566-17-1Available | 2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene |
| CANA-016 | 492-62-6 | (2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol |
| CANA-017 | 1213234-53-7 | (2R,3R,4S,5R,6R)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(2,2-dimethylpropanoate) |
| CANA-018 | 81058-27-7 | (2R,3R,4S,5R,6R)-2-bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate) |
| CANA-019 | 1283129-18-9 | (2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate) |
Frequently asked questions
What are the approved indications of Canagliflozin/Metformin Hydrochloride?
Approved indications include: End-stage renal disease, Cardiac and vascular disorders, Abdominal aortic aneurysm, Type 2 diabetes.
When does the Canagliflozin/Metformin Hydrochloride patent expire?
Based on public sources, the Canagliflozin/Metformin Hydrochloride patent expires in 2029.
How many synthesis routes are recorded for Canagliflozin/Metformin Hydrochloride?
3 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Canagliflozin/Metformin Hydrochloride intermediates?
5 intermediate CAS of Canagliflozin/Metformin Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Canagliflozin/Metformin Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29