Ipragliflozin L-Proline

Tier C — Watch / trade

Astellas Pharma Inc.

Originator

2014

First approval

Expiry (public)

$0.26B ▲

Peak sales

Small molecule

Type

Targets：SGLT2

Brand：Suglat

Indications (approved)：Type 2 diabetes, Type 1 diabetes

Regional status

No progress

2008-10-23

No progress

2010-04-06

China

Phase I

2013-01-25

Japan

Approved

2014-01-17

Factories producing this API7

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

7 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 63 mg

IPRA-00193777-26-5IPRA-00295-15-8IPRA-0031034305-11-7IPRA-004761424-75-3IPRA-00513096-62-3IPRA-006—IPRA-007761425-14-3IPRA-008761423-01-2API · Ipragliflozin L-Proline

Code	CAS No.	Intermediate
IPRA-001	93777-26-5 Available	5-bromo-2-fluorobenzaldehyde
IPRA-002	95-15-8	benzo[b]thiophene
IPRA-003	1034305-11-7 Available	benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol
IPRA-004	761424-75-3	(benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methoxy)(tert-butyl)dimethylsilane
IPRA-005	13096-62-3 Available	(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one
IPRA-006	-	(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl((tert-butyldimethylsilyl)oxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
IPRA-007	761425-14-3	(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl(hydroxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
IPRA-008	761423-01-2	(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran

OptimisedRoute 2Steps 5 · Total yield /

IPRA-00193777-26-5IPRA-00295-15-8IPRA-0031034305-11-7IPRA-00513096-62-3IPRA-008761423-01-2IPRA-0091034305-17-3IPRA-010—API · Ipragliflozin L-Proline

Code	CAS No.	Intermediate
IPRA-001	93777-26-5 Available	5-bromo-2-fluorobenzaldehyde
IPRA-002	95-15-8	benzo[b]thiophene
IPRA-003	1034305-11-7 Available	benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol
IPRA-005	13096-62-3 Available	(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one
IPRA-008	761423-01-2	(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran
IPRA-009	1034305-17-3 Available	2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene
IPRA-010	-	(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol

OptimisedRoute 4Steps 1 · Total yield 3.58 g

IPRA-0091034305-17-3IPRA-01774372-90-0IPRA-0181825379-70-1API · Ipragliflozin L-Proline

Code	CAS No.	Intermediate
IPRA-009	1034305-17-3 Available	2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene
IPRA-017	74372-90-0	(1S,3R,4R,5S,6R)-4,5-bis(benzyloxy)-3-((benzyloxy)methyl)-2,7-dioxabicyclo[4.1.0]heptane
IPRA-018	1825379-70-1	(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-ol

ProcessRoute 3Steps 8 · Total yield 1.7 g

IPRA-00193777-26-5IPRA-00295-15-8IPRA-0031034305-11-7IPRA-0091034305-17-3IPRA-0111034305-19-5IPRA-01232384-65-9IPRA-0131034305-23-1IPRA-0141034305-27-5IPRA-0151034305-21-9IPRA-016147-85-3API · Ipragliflozin L-Proline

Code	CAS No.	Intermediate
IPRA-001	93777-26-5 Available	5-bromo-2-fluorobenzaldehyde
IPRA-002	95-15-8	benzo[b]thiophene
IPRA-003	1034305-11-7 Available	benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol
IPRA-009	1034305-17-3 Available	2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene
IPRA-011	1034305-19-5	2-((5-bromo-2-fluorophenyl)chloromethyl)benzo[b]thiophene
IPRA-012	32384-65-9 Available	(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
IPRA-013	1034305-23-1	(2S,3R,4S,5S,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
IPRA-014	1034305-27-5	(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate
IPRA-015	1034305-21-9 Available	(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
IPRA-016	147-85-3	(S)-pyrrolidine-2-carboxylic acid

Frequently asked questions

What are the approved indications of Ipragliflozin L-Proline?

Approved indications include: Type 2 diabetes, Type 1 diabetes.

When does the Ipragliflozin L-Proline patent expire?

No public expiry year is available for Ipragliflozin L-Proline yet; this page updates once verified.

How many synthesis routes are recorded for Ipragliflozin L-Proline?

4 synthesis routes are recorded; the shortest is 1 steps with 3.58 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ipragliflozin L-Proline intermediates?

6 intermediate CAS of Ipragliflozin L-Proline are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ipragliflozin L-Proline intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29