Gefitinib

Tier C — Watch / trade

Gefitinib

AstraZeneca

Originator

2002

First approval

Expiry (public)

$0.65B ▲

Peak sales

Small molecule

Type

Targets：EGFR, EGFR 19del, EGFR L858R

Brand：Iressa

Indications (approved)：Non-small cell lung cancer

Regional status

Withdrawn

Approved

2009-06-24

China

Approved

2004-12-06

Japan

Approved

2002-07-05

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

1 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 2Steps 6 · Total yield 29.5 g

GEFT-0037357-67-7GEFT-010367-21-5GEFT-01113794-72-4GEFT-01263-68-3GEFT-013179688-52-9GEFT-014179688-53-0GEFT-015179688-54-1GEFT-016788136-89-0GEFT-017184475-71-6API · Gefitinib

Code	CAS No.	Intermediate
GEFT-003	7357-67-7 Available	4-(3-chloropropyl)morpholine
GEFT-010	367-21-5	3-chloro-4-fluoroaniline
GEFT-011	13794-72-4 Available	6,7-dimethoxyquinazolin-4(3H)-one
GEFT-012	63-68-3	L-methionine
GEFT-013	179688-52-9	6-hydroxy-7-methoxyquinazolin-4(3H)-one
GEFT-014	179688-53-0	7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate
GEFT-015	179688-54-1	4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride
GEFT-016	788136-89-0	4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
GEFT-017	184475-71-6	4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol

OptimisedRoute 1Steps 8 · Total yield 0.12 g

GEFT-001621-59-0GEFT-00252805-46-6GEFT-0037357-67-7GEFT-004675126-28-0GEFT-005675126-26-8GEFT-006675126-27-9GEFT-007246512-44-7GEFT-008199327-61-2GEFT-009199327-59-8GEFT-010367-21-5API · Gefitinib

Code	CAS No.	Intermediate
GEFT-001	621-59-0	3-hydroxy-4-methoxybenzaldehyde
GEFT-002	52805-46-6	3-hydroxy-4-methoxybenzonitrile
GEFT-003	7357-67-7 Available	4-(3-chloropropyl)morpholine
GEFT-004	675126-28-0	4-methoxy-3-(3-morpholinopropoxy)benzonitrile
GEFT-005	675126-26-8 Available	4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
GEFT-006	675126-27-9	2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
GEFT-007	246512-44-7	2-amino-4-methoxy-5-(3-morpholinopropoxy)benzamide
GEFT-008	199327-61-2	7-methoxy-6-(3-morpholinopropoxy)quinazolin-4(1H)-one
GEFT-009	199327-59-8	4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine
GEFT-010	367-21-5	3-chloro-4-fluoroaniline

OptimisedRoute 3Steps 6 · Total yield 0.48 g

GEFT-001621-59-0GEFT-00252805-46-6GEFT-0037357-67-7GEFT-004675126-28-0GEFT-005675126-26-8GEFT-006675126-27-9GEFT-010367-21-5GEFT-018727658-04-0API · Gefitinib

Code	CAS No.	Intermediate
GEFT-001	621-59-0	3-hydroxy-4-methoxybenzaldehyde
GEFT-002	52805-46-6	3-hydroxy-4-methoxybenzonitrile
GEFT-003	7357-67-7 Available	4-(3-chloropropyl)morpholine
GEFT-004	675126-28-0	4-methoxy-3-(3-morpholinopropoxy)benzonitrile
GEFT-005	675126-26-8 Available	4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
GEFT-006	675126-27-9	2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
GEFT-010	367-21-5	3-chloro-4-fluoroaniline
GEFT-018	727658-04-0	(E)-N,N'-bis(3-chloro-4-fluorophenyl)formimidamide

OptimisedRoute 4Steps 6 · Total yield 66.7 g

GEFT-0037357-67-7GEFT-010367-21-5GEFT-013179688-52-9GEFT-017184475-71-6GEFT-01993-07-2GEFT-0204998-07-6GEFT-02131839-21-1API · Gefitinib

Code	CAS No.	Intermediate
GEFT-003	7357-67-7 Available	4-(3-chloropropyl)morpholine
GEFT-010	367-21-5	3-chloro-4-fluoroaniline
GEFT-013	179688-52-9	6-hydroxy-7-methoxyquinazolin-4(3H)-one
GEFT-017	184475-71-6	4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
GEFT-019	93-07-2	3,4-dimethoxybenzoic acid
GEFT-020	4998-07-6	4,5-dimethoxy-2-nitrobenzoic acid
GEFT-021	31839-21-1	2-amino-5-hydroxy-4-methoxybenzoic acid

Frequently asked questions

What are the approved indications of Gefitinib?

Approved indications include: Non-small cell lung cancer.

When does the Gefitinib patent expire?

No public expiry year is available for Gefitinib yet; this page updates once verified.

How many synthesis routes are recorded for Gefitinib?

4 synthesis routes are recorded; the shortest is 6 steps with 29.5 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Gefitinib intermediates?

3 intermediate CAS of Gefitinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Gefitinib intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29