Dienogest

Tier C — Watch / trade

Dienogest

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：PR

Brand：Visanne, Endometrion, Dinagest

Indications (approved)：Contraception, Endocrine system disorder, Endometriosis

Regional status

No progress

2004-07-01

China

Approved

2018-12-17

Japan

Synthetic routes & intermediates7 routes

Originator routes × 0Optimised (non-patent) × 7Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 2 · Total yield /

(I)90248-1-a65928-65-6(II)90248-1-a—API · Dienogest

Code	CAS No.	Intermediate
(I)90248-1-a	65928-65-6	2-(17beta-Hydroxy-3-oxoestr-5(10)-en-17-yl)acetonitrile
(II)90248-1-a	-	2-[(10S,11S,14R,15S)-2,7-dibromo-14-hydroxy-15-methyl-5-oxotetracyclo[8.7.0.0(2,7).0(11,15)]heptadecan-14-yl]acetonitrile

OptimisedRoute 2Steps 4 · Total yield /

(I)90248-2-a17976-32-8(II)90248-2-a—(III)90248-2-a30925-89-4(IV)90248-2-a65928-64-5(V)90248-2-a—(VI)90248-2-a—(VII)90248-2-a—(VIII)90248-2-a75-05-8API · Dienogest

Code	CAS No.	Intermediate
(I)90248-2-a	17976-32-8	3-Methoxyestra-2,5(10)-dien-17-one
(II)90248-2-a	-	dimethyl(methylidene)-sulfane
(III)90248-2-a	30925-89-4	(1'S,2S,10'R,11'S,15'S)-5'-methoxy-15'-methylspiro[oxirane-2,14'-tetracyclo[8.7.0.0(2,7).0(11,15)]heptadecane]-2'(7'),4'-diene
(IV)90248-2-a	65928-64-5	2-(17beta-Hydroxy-3-methoxyestra-2,5(10)-dien-17-yl)acetonitrile
(V)90248-2-a	-	2-[(1S,10R,11S,14R,15S)-14-hydroxy-15-methyl-5-oxotetracyclo[8.7.0.0(2,7).0(11,15)]heptadec-2(7)-en-14-yl]acetonitrile
(VI)90248-2-a	-	3,3-Dimethoxyestra-5,9-dien-17-one
(VII)90248-2-a	-	3-Ethoxyestra-3,5,9-trien-17-one
(VIII)90248-2-a	75-05-8	Acetonitrile anhydrous

OptimisedRoute 3Steps 4 · Total yield /

(I)90248-3-a5173-46-6(II)90248-3-a126-30-7(III)90248-3-a91175-92-7(IV)90248-3-a1253857-90-7(V)90248-3-a1253857-91-8API · Dienogest

Code	CAS No.	Intermediate
(I)90248-3-a	5173-46-6	Estra-4,9-diene-3,17-dione
(II)90248-3-a	126-30-7	1,3-Dihydroxy-2,2-dimethylpropane
(III)90248-3-a	91175-92-7	3,3-(2,2-Dimethyl-1,3-propylenedioxy)estra-5(10),9(11)-dien-17-one
(IV)90248-3-a	1253857-90-7	3,3-(2,2-Dimethyl-1,3-propylenedioxy)-17beta,17beta-(methyleneoxy)estra-5(10),9(11)-diene
(V)90248-3-a	1253857-91-8	2-[3,3-(2,2-Dimethyl-1,3-propylenedioxy)-17beta-hydroxyestra-5(10),9(11)-dien-17-yl]acetonitrile

OptimisedRoute 4Steps 6 · Total yield /

(I)90248-4-a1624-62-0(II)90248-4-a133291-95-9(III)90248-4-a1255910-17-8(IV)90248-4-a17976-32-8(V)90248-4-a65928-64-5(VI)90248-4-a65928-65-6(VII)90248-4-a24284-84-2(VIII)90248-4-a110169-67-0API · Dienogest

Code	CAS No.	Intermediate
(I)90248-4-a	1624-62-0	3-Methoxyestra-1,3,5(10)-trien-17-one
(II)90248-4-a	133291-95-9	3,17,17-Trimethoxyestra-1(10),2,4-triene
(III)90248-4-a	1255910-17-8	3,17,17-Trimethoxyestra-2,5(10)-diene
(IV)90248-4-a	17976-32-8	3-Methoxyestra-2,5(10)-dien-17-one
(V)90248-4-a	65928-64-5	2-(17beta-Hydroxy-3-methoxyestra-2,5(10)-dien-17-yl)acetonitrile
(VI)90248-4-a	65928-65-6	2-(17beta-Hydroxy-3-oxoestr-5(10)-en-17-yl)acetonitrile
(VII)90248-4-a	24284-84-2	2-(17beta-Hydroxy-3-methoxyestra-1(10),2,4-trien-17-yl)acetonitrile
(VIII)90248-4-a	110169-67-0	3-Methoxyestra-2,5(10)-dien-17-ol

OptimisedRoute 5Steps 2 · Total yield /

(I)90248-5-a10109-76-9(II)90248-5-a75-05-8(III)90248-5-a102193-41-9API · Dienogest

Code	CAS No.	Intermediate
(I)90248-5-a	10109-76-9	3,3-Dimethoxyestra-5(10),9(11)-dien-17-one
(II)90248-5-a	75-05-8	Acetonitrile anhydrous
(III)90248-5-a	102193-41-9	17alpha-(Cyanomethyl)-3,3-dimethoxy-13beta-methylgonane-5(10),9(11)-dien-17beta-ol

OptimisedRoute 6Steps 2 · Total yield /

(III)90248-6-a190662-30-7(I)90248-6-a5571-36-8(II)90248-6-a75-05-8API · Dienogest

Code	CAS No.	Intermediate
(III)90248-6-a	190662-30-7	[(8S,13S,14S,17R)-17-Hydroxy-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl]acetonitrile
(I)90248-6-a	5571-36-8	17-Oxo-estradiene
(II)90248-6-a	75-05-8	Acetonitrile anhydrous

OptimisedRoute 7Steps 4 · Total yield /

(Ia)125457-3-a88128-57-8(Ib)125457-3-a88128-58-9(II)125457-3-a1700622-26-9(III)125457-3-a1700616-94-9(IV)125457-3-a88128-63-6(V)125457-3-a88128-61-4(VI)125457-3-a5173-46-6API · Dienogest

Code	CAS No.	Intermediate
(Ia)125457-3-a	88128-57-8	2-(3-Chloropropyl)-2,5,5-trimethyl-1,3-dioxane
(Ib)125457-3-a	88128-58-9	2-(3-Bromopropyl)-2,5,5-trimethyl-1,3-dioxane
(II)125457-3-a	1700622-26-9	(6aS,9aS,9bS)-6a-Methyldecahydrocyclopenta[f]chromene-3,7-dione
(III)125457-3-a	1700616-94-9	(3aS,4S,7aS)-5-Hydroxy-7a-methyl-4-[3-oxo-6-(2,5,5-trimethyl-1,3-dioxan-2-yl)hexyl]octahydro-1H-inden-1-one
(IV)125457-3-a	88128-63-6	(3aS,4S,7aS)-7a-Methyl-4-[3-oxo-6-(2,5,5-trimethyl-1,3-dioxan-2-yl)hexyl]hexahydro-1H-indene-1,5(4H)-dione
(V)125457-3-a	88128-61-4	(3aS,9aS,9bS)-3a-Methyl-6-[2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethyl]-4,5,8,9,9a,9b-hexahydro-1H-cyclopenta[a]naphthalene-3,7(2H,3aH)-dione
(VI)125457-3-a	5173-46-6	Estra-4,9-diene-3,17-dione

Frequently asked questions

What are the approved indications of Dienogest?

Approved indications include: Contraception, Endocrine system disorder, Endometriosis.

When does the Dienogest patent expire?

No public expiry year is available for Dienogest yet; this page updates once verified.

How many synthesis routes are recorded for Dienogest?

7 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Dienogest intermediates?

All intermediates in Dienogest routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Dienogest intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29