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Parecoxib Sodium

Tier C — Watch / trade

Parecoxib Sodium

Pfizer Inc.
Originator
2002
First approval
-
Expiry (public)
$0B ▲
Peak sales
Small molecule
Type

Targets:COX-2

Brand:Rayzon, Xapit, Dynastat

Indications (approved):Postoperative pain

Regional status

US
-
EU
Phase II
2025-01-01
China
Approved
2008-03-24
Japan
-

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 5 · Total yield 12.2 g
PARE-001451-40-1PARE-002952-06-7PARE-003181696-73-1PARE-004181695-72-7PARE-005123-62-6PARE-006198470-84-7API · Parecoxib Sodium
CodeCAS No.Intermediate
PARE-001451-40-1Available1,2-diphenylethan-1-one
PARE-002952-06-7Available(E)-1,2-diphenylethan-1-one oxime
PARE-003181696-73-1Available5-methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol
PARE-004181695-72-7Available4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
PARE-005123-62-6Availablepropionic anhydride
PARE-006198470-84-7AvailableN-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide
OptimisedRoute 2Steps 3 · Total yield /
PARE-004181695-72-7PARE-0071428235-75-9PARE-0081008-74-8PARE-00931295-65-5PARE-010613660-87-0API · Parecoxib Sodium
CodeCAS No.Intermediate
PARE-004181695-72-7Available4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
PARE-0071428235-75-9Available(E)-1-phenylbut-3-en-1-one oxime
PARE-0081008-74-8Available5-methyl-3-phenylisoxazole
PARE-00931295-65-5Available4-bromo-5-methyl-3-phenylisoxazole
PARE-010613660-87-0Available(4-sulfamoylphenyl)boronic acid
OptimisedRoute 3Steps 7 · Total yield 9.11 g
PARE-001451-40-1PARE-003181696-73-1PARE-004181695-72-7PARE-005123-62-6PARE-006198470-84-7PARE-01142353-58-2PARE-012872216-69-8PARE-01337928-17-9API · Parecoxib Sodium
CodeCAS No.Intermediate
PARE-001451-40-1Available1,2-diphenylethan-1-one
PARE-003181696-73-1Available5-methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol
PARE-004181695-72-7Available4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
PARE-005123-62-6Availablepropionic anhydride
PARE-006198470-84-7AvailableN-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide
PARE-01142353-58-2Available(Z)-1-(1,2-diphenylvinyl)pyrrolidine
PARE-012872216-69-8Available(Z)-3,4-diphenyl-4-(pyrrolidin-1-yl)but-3-en-2-one
PARE-01337928-17-9Available5-methyl-3,4-diphenylisoxazole
OptimisedRoute 4Steps 5 · Total yield 11.9 g
PARE-001451-40-1PARE-004181695-72-7PARE-005123-62-6PARE-0141356834-10-0PARE-0151356834-09-7PARE-016181696-35-5API · Parecoxib Sodium
CodeCAS No.Intermediate
PARE-001451-40-1Available1,2-diphenylethan-1-one
PARE-004181695-72-7Available4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
PARE-005123-62-6Availablepropionic anhydride
PARE-0141356834-10-0Available4-(2-oxo-2-phenylethyl)benzenesulfonic acid
PARE-0151356834-09-7Available4-(1,3-dioxo-1-phenylbutan-2-yl)benzenesulfonic acid
PARE-016181696-35-5Available4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid

Frequently asked questions

What are the approved indications of Parecoxib Sodium?

Approved indications include: Postoperative pain.

When does the Parecoxib Sodium patent expire?

No public expiry year is available for Parecoxib Sodium yet; this page updates once verified.

How many synthesis routes are recorded for Parecoxib Sodium?

4 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Parecoxib Sodium intermediates?

16 intermediate CAS of Parecoxib Sodium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Parecoxib Sodium intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29