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Dazdotuftide
Tier C — Watch / tradeDazdotuftide
Tarsius Pharma
Originator
-
First approval
-
Expiry (public)
No sales data
Peak sales
-
Type
Targets：NF-κB
Indications (approved)：葡萄膜炎, 前葡萄膜炎, Glaucoma, 眼睛发炎
Regional status
US
Phase III
2021-09-20
EU
Phase III
2021-09-20
China
-
Japan
-
Synthetic routes & intermediates2 routes
Originator routes × 0Optimised (non-patent) × 2Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 5 · Total yield /
(I)1062329-1-a—(II)1062329-1-a—(IIIb)1062329-1-a3978-80-1(IVa)1062329-1-a—(IVb)1062329-1-a—(V)1062329-1-a—(VIa)1062329-1-a29022-11-5(VIb)1062329-1-a4530-20-5(VII)1062329-1-a—(VIIIa)1062329-1-a154445-77-9(VIIIb)1062329-1-a200124-22-7(IX)1062329-1-a,(IX)1062329-1-b—API · Dazdotuftide
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1062329-1-a | - | 4-Aminophenyl 2-(trimethylammonio)ethyl phosphate |
| (II)1062329-1-a | - | 4-Diazoniophenyl 2-(trimethylazaniumyl)ethyl phosphate chloride |
| (IIIb)1062329-1-a | 3978-80-1 | (2S)-3-(4-Hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid |
| (IVa)1062329-1-a | - | N-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine |
| (IVb)1062329-1-a | - | N-(tert-Butoxycarbonyl)-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine |
| (V)1062329-1-a | - | Resin bound 3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine |
| (VIa)1062329-1-a | 29022-11-5 | 2-(9H-Fluoren-9-ylmethoxycarbonylamino)acetic acid |
| (VIb)1062329-1-a | 4530-20-5Available | 2-((tert-Butoxycarbonyl)amino)acetic acid |
| (VII)1062329-1-a | - | Resin bound glycyl-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine |
| (VIIIa)1062329-1-a | 154445-77-9 | (2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-5-[2-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentanoic acid |
| (VIIIb)1062329-1-a | 200124-22-7 | (2S)-2-{[(tert-Butoxy)carbonyl]amino}-5-{N'-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}pentanoic acid |
| (IX)1062329-1-a,(IX)1062329-1-b | - | Resin bound N5-[N-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidoyl]-L-ornithylglycyl-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine |
OptimisedRoute 2Steps 4 · Total yield /
(IX)1062329-1-a,(IX)1062329-1-b—(Xa)1062329-1-b71989-31-6(Xb)1062329-1-b15761-39-4(XI)1062329-1-b—(XIIa)1062329-1-b71989-26-9(XIIb)1062329-1-b2483-46-7(XIII)1062329-1-b—(XIVa)1062329-1-b71989-35-0(XIVb)1062329-1-b13734-40-2(XV)1062329-1-b—(XVI)1062329-1-b—API · Dazdotuftide
| Code | CAS No. | Intermediate |
|---|---|---|
| (IX)1062329-1-a,(IX)1062329-1-b | - | Resin bound N5-[N-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidoyl]-L-ornithylglycyl-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine |
| (Xa)1062329-1-b | 71989-31-6 | (2S)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid |
| (Xb)1062329-1-b | 15761-39-4 | (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid |
| (XI)1062329-1-b | - | Resin bound [(2S)-3-(4-hydroxy-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]phenyl)-2-([L-prolyl-N5-[N-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidoyl]-L-ornithylglycyl]amino)propanoyl]oxy |
| (XIIa)1062329-1-b | 71989-26-9 | (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid |
| (XIIb)1062329-1-b | 2483-46-7 | (2S)-2,6-Bis({[(tert-butoxy)carbonyl]amino})hexanoic acid |
| (XIII)1062329-1-b | - | Resin bound [(2S)-2-([N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-N5-[N-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidoyl]-L-ornithylglycyl]amino)-3-(4-hydroxy-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]phenyl)propanoyl]oxy |
| (XIVa)1062329-1-b | 71989-35-0 | O-tert-Butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonine |
| (XIVb)1062329-1-b | 13734-40-2 | N-(tert-Butoxycarbonyl)-O-tert-butyl-L-threonine |
| (XV)1062329-1-b | - | Resin bound [(2S)-2-([O-tert-butyl-L-threonyl-N6-(tert-butoxycarbonyl)-L-lysyl-L-prolyl-N5-[N-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidoyl]-L-ornithylglycyl]amino)-3-(4-hydroxy-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]phenyl)propanoyl]oxy |
| (XVI)1062329-1-b | - | L-Threonyl-L-lysyl-L-prolyl-L-arginylglycyl-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine--trifluoroacetic acid (1/1) |
Frequently asked questions
What are the approved indications of Dazdotuftide?
Approved indications include: 葡萄膜炎, 前葡萄膜炎, Glaucoma, 眼睛发炎.
When does the Dazdotuftide patent expire?
No public expiry year is available for Dazdotuftide yet; this page updates once verified.
How many synthesis routes are recorded for Dazdotuftide?
2 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Dazdotuftide intermediates?
1 intermediate CAS of Dazdotuftide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Dazdotuftide intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-21