Estradiol Valerate

Tier C — Watch / trade

Estradiol Valerate

Endo Pharmaceuticals

Originator

1954

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：ERs

Brand：Climaval, Progynova, Progynon Depot, Estradiol Jenapharm, Estradiol-Depot Jenapharm, Delestrogen

Indications (approved)：Oestrogen deficiency syndrome, Prostate cancer, Vulvovaginal atrophy, Hypogonadism, Vasomotor symptoms

Regional status

Approved

1954-07-15

Approved

1996-09-26

China

Approved

1983-01-01

Japan

Approved

1954-11-01

Synthetic routes & intermediates1 routes

Originator routes × 0Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 3 · Total yield 90g(Estradiol Valerate (Free))

Estradiol Valerate-001—Estradiol Valerate-002—Estradiol Valerate-00363042-28-4Estradiol Valerate-004—API · Estradiol Valerate

Code	CAS No.	Intermediate
Estradiol Valerate-001	-	(17beta)-Estra-1,3,5(10)-triene-3,17-diol
Estradiol Valerate-002	-	Pentanoic anhydride
Estradiol Valerate-003	63042-28-4	(17beta)-Estra-1,3,5(10)-triene-3,17-diyl dipentanoate
Estradiol Valerate-004	-	Butanecarboxylic acid

Frequently asked questions

What are the approved indications of Estradiol Valerate?

Approved indications include: Oestrogen deficiency syndrome, Prostate cancer, Vulvovaginal atrophy, Hypogonadism, Vasomotor symptoms.

When does the Estradiol Valerate patent expire?

No public expiry year is available for Estradiol Valerate yet; this page updates once verified.

How many synthesis routes are recorded for Estradiol Valerate?

1 synthesis routes are recorded; the shortest is 3 steps with 90g(Estradiol Valerate (Free)) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Estradiol Valerate intermediates?

All intermediates in Estradiol Valerate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Estradiol Valerate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29