Rivaroxaban
Tier A — Act nowRivaroxaban · all drugs expiring in 2026 →
Targets：F10
Brand：Xarelto
Indications (approved)：Pulmonary embolism, Stroke, Congenital heart defect, Thrombosis, Venous thromboembolism, Coronary artery disease, Coronary artery lesion, Peripheral arterial disease
Regional status
Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
1 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates6 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| RIVA-001 | 141-43-5Available | 2-aminoethan-1-ol |
| RIVA-002 | 79-04-9Available | 2-chloroacetyl chloride |
| RIVA-003 | - | 2-(2-chloroacetamido)ethyl 2-chloroacetate |
| RIVA-004 | 6320-16-7Available | 2-chloro-N-(2-hydroxyethyl)acetamide |
| RIVA-005 | 109-11-5Available | morpholin-3-one |
| RIVA-006 | 350-46-9Available | 1-fluoro-4-nitrobenzene |
| RIVA-007 | 446292-04-2Available | 4-(4-nitrophenyl)morpholin-3-one |
| RIVA-008 | 438056-69-0Available | 4-(4-aminophenyl)morpholin-3-one |
| RIVA-009 | 161596-47-0Available | (S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione |
| RIVA-010 | 446292-07-5Available | (R)-2-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione |
| RIVA-011 | 446292-08-6Available | (S)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione |
| RIVA-012 | 1430407-73-0Available | (S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one oxalate |
| RIVA-013 | 42518-98-9Available | 5-chlorothiophene-2-carbonyl chloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| RIVA-008 | 438056-69-0Available | 4-(4-aminophenyl)morpholin-3-one |
| RIVA-013 | 42518-98-9Available | 5-chlorothiophene-2-carbonyl chloride |
| RIVA-014 | 7283-96-7Available | 5-chlorothiophene-2-carbaldehyde |
| RIVA-015 | 24065-33-6Available | 5-chlorothiophene-2-carboxylic acid |
| RIVA-016 | 209849-99-0Available | (S)-3-aminopropane-1,2-diol hydrochloride |
| RIVA-017 | 721401-51-0Available | (S)-5-chloro-N-(2,3-dihydroxypropyl)thiophene-2-carboxamide |
| RIVA-018 | 721401-52-1Available | (S)-N-(3-bromo-2-hydroxypropyl)-5-chlorothiophene-2-carboxamide |
| RIVA-019 | 721401-53-2Available | (R)-5-chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| RIVA-002 | 79-04-9Available | 2-chloroacetyl chloride |
| RIVA-007 | 446292-04-2Available | 4-(4-nitrophenyl)morpholin-3-one |
| RIVA-008 | 438056-69-0Available | 4-(4-aminophenyl)morpholin-3-one |
| RIVA-013 | 42518-98-9Available | 5-chlorothiophene-2-carbonyl chloride |
| RIVA-020 | 122-98-5Available | 2-(phenylamino)ethan-1-ol |
| RIVA-021 | 29518-11-4Available | 4-phenylmorpholin-3-one |
| RIVA-022 | 501-53-1Available | benzyl carbonochloridate |
| RIVA-023 | 1313613-18-1Available | benzyl (4-(3-oxomorpholino)phenyl)carbamate |
| RIVA-024 | 60456-26-0Available | (R)-oxiran-2-ylmethyl butyrate |
| RIVA-025 | 1117893-60-3Available | (R)-4-(4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one |
| RIVA-026 | 1117893-61-4Available | (R)-(2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl methanesulfonate |
| RIVA-027 | 75-64-9Available | 2-methylpropan-2-amine |
| RIVA-028 | 1313613-19-2Available | (S)-4-(4-(5-((tert-butylamino)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one |
| RIVA-029 | 1313613-21-6Available | (S)-N-(tert-butyl)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| RIVA-013 | 42518-98-9Available | 5-chlorothiophene-2-carbonyl chloride |
| RIVA-023 | 1313613-18-1Available | benzyl (4-(3-oxomorpholino)phenyl)carbamate |
| RIVA-030 | 67843-74-7Available | (S)-2-(chloromethyl)oxirane |
| RIVA-031 | 100-52-7Available | benzaldehyde |
| RIVA-032 | 224323-52-8Available | (S,E)-1-(benzylideneamino)-3-chloropropan-2-ol |
| RIVA-033 | 34839-13-9Available | (S)-1-amino-3-chloropropan-2-ol hydrochloride |
| RIVA-034 | 1384257-81-1Available | (S)-5-chloro-N-(3-chloro-2-hydroxypropyl)thiophene-2-carboxamide |
| RIVA-035 | - | (S)-1-chloro-3-(5-chlorothiophene-2-carboxamido)propan-2-yl acetate |
| Code | CAS No. | Intermediate |
|---|---|---|
| RIVA-008 | 438056-69-0Available | 4-(4-aminophenyl)morpholin-3-one |
| RIVA-013 | 42518-98-9Available | 5-chlorothiophene-2-carbonyl chloride |
| RIVA-025 | 1117893-60-3Available | (R)-4-(4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one |
| RIVA-036 | 16495-04-8Available | (S)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzenesulfonate |
| RIVA-037 | 1018979-25-3Available | (S)-1-(benzyloxy)-3-(tosyloxy)propan-2-yl acetate |
| RIVA-038 | 1447919-68-7Available | (R)-1-(benzyloxy)-3-((4-(3-oxomorpholino)phenyl)amino)propan-2-yl acetate |
| RIVA-039 | 1447919-69-8Available | (R)-1-(benzyloxy)-3-((chlorocarbonyl)(4-(3-oxomorpholino)phenyl)amino)propan-2-yl acetate |
| RIVA-040 | 1117893-59-0Available | (R)-4-(4-(5-((benzyloxy)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one |
| RIVA-041 | 1424942-80-2Available | (R)-(2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzenesulfonate |
| RIVA-042 | 1424942-78-8Available | (S)-4-(4-(5-((benzylamino)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one |
| RIVA-043 | 1429333-90-3Available | (S)-N-benzyl-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| RIVA-008 | 438056-69-0Available | 4-(4-aminophenyl)morpholin-3-one |
| RIVA-014 | 7283-96-7Available | 5-chlorothiophene-2-carbaldehyde |
| RIVA-030 | 67843-74-7Available | (S)-2-(chloromethyl)oxirane |
| RIVA-044 | 681225-50-3Available | (S)-1-azido-3-chloropropan-2-ol |
| RIVA-045 | 127182-48-3Available | (S)-2-(azidomethyl)oxirane |
| RIVA-046 | 1429334-05-3Available | (R)-4-(4-((3-azido-2-hydroxypropyl)amino)phenyl)morpholin-3-one |
| RIVA-047 | 1349248-79-8Available | (R)-4-(4-(5-(azidomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one |
| RIVA-048 | 446292-10-0Available | (S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one |
Frequently asked questions
What are the approved indications of Rivaroxaban?
Approved indications include: Pulmonary embolism, Stroke, Congenital heart defect, Thrombosis, Venous thromboembolism, Coronary artery disease, Coronary artery lesion, Peripheral arterial disease.
When does the Rivaroxaban patent expire?
Based on public sources, the Rivaroxaban patent expires in 2026.
How many synthesis routes are recorded for Rivaroxaban?
6 synthesis routes are recorded; the shortest is 5 steps with 3.34 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Rivaroxaban intermediates?
46 intermediate CAS of Rivaroxaban are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Rivaroxaban intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29