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Rabeprazole Sodium

Tier B — Position early

Rabeprazole Sodium

Eisai Co., Ltd.
Originator
1997
First approval
-
Expiry (public)
$1.6B ▲
Peak sales
Small molecule
Type

Targets:Proton pump

Brand:Aciphex, Aciphex Sprinkle, Pariet, Aciphex/Pariet, Achipex

Indications (approved):Gastro-oesophageal reflux disease, Peptic oesophagitis, Duodenal ulcer, Gastric ulcer, Zollinger-Ellison syndrome, Heartburn, Helicobacter pylori infection, Helicobacter infection

Regional status

US
Approved
1999-08-19
EU
Discontinued
2008-02-01
China
Approved
2000-02-03
Japan
Approved
1997-10-14

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield 530 mg
RABE-0011589-49-7RABE-00259886-90-7RABE-003117977-18-1RABE-004117977-20-5RABE-005583-39-1RABE-006117977-21-6API · Rabeprazole Sodium
CodeCAS No.Intermediate
RABE-0011589-49-73-methoxypropan-1-ol
RABE-00259886-90-74-chloro-2,3-dimethylpyridine 1-oxide
RABE-003117977-18-14-(3-methoxypropoxy)-2,3-dimethylpyridine 1-oxide
RABE-004117977-20-52-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine
RABE-005583-39-11H-benzo[d]imidazole-2-thiol
RABE-006117977-21-62-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
OptimisedRoute 2Steps 3 · Total yield 40.32 kg
RABE-005583-39-1RABE-006117977-21-6RABE-007153259-31-5RABE-008117976-89-3API · Rabeprazole Sodium
CodeCAS No.Intermediate
RABE-005583-39-11H-benzo[d]imidazole-2-thiol
RABE-006117977-21-62-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
RABE-007153259-31-52-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride
RABE-008117976-89-32-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
OptimisedRoute 3Steps 1 · Total yield /
RABE-006117977-21-6API · Rabeprazole Sodium
CodeCAS No.Intermediate
RABE-006117977-21-62-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
OptimisedRoute 4Steps 1 · Total yield 92.4 g
RABE-005583-39-1RABE-009117977-20-5API · Rabeprazole Sodium
CodeCAS No.Intermediate
RABE-005583-39-11H-benzo[d]imidazole-2-thiol
RABE-009117977-20-52-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine
OptimisedRoute 5Steps 2 · Total yield /
RABE-004117977-20-5RABE-005583-39-1RABE-008117976-89-3RABE-010924663-39-8API · Rabeprazole Sodium
CodeCAS No.Intermediate
RABE-004117977-20-52-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine
RABE-005583-39-11H-benzo[d]imidazole-2-thiol
RABE-008117976-89-32-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
RABE-010924663-39-82-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide

Frequently asked questions

What are the approved indications of Rabeprazole Sodium?

Approved indications include: Gastro-oesophageal reflux disease, Peptic oesophagitis, Duodenal ulcer, Gastric ulcer, Zollinger-Ellison syndrome, Heartburn, Helicobacter pylori infection, Helicobacter infection.

When does the Rabeprazole Sodium patent expire?

No public expiry year is available for Rabeprazole Sodium yet; this page updates once verified.

How many synthesis routes are recorded for Rabeprazole Sodium?

5 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Rabeprazole Sodium intermediates?

All intermediates in Rabeprazole Sodium routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Rabeprazole Sodium intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29