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Telmisartan/Amlodipine Besylate/Hydrochlorothiazide

Tier C — Watch / trade

Telmisartan/Amlodipine Besylate/Hydrochlorothiazide

Boehringer Ingelheim
Originator
2016
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets:Thiazide-sensitive sodium-chloride cotransporter, AT1, VDCCs

Brand:TwoTops Plus, Micatrio

Indications (approved):Hypertension

Regional status

US
-
EU
-
China
-
Japan
Approved
2016-09-28

Factories producing this API13

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

13 producing factories on file — sign in to view the named list (factory details are not shown to guests).

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Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 8 · Total yield /
TELM-00118595-14-7TELM-002141-75-3TELM-003301533-59-5TELM-004152628-01-8TELM-005675882-71-0TELM-006152628-00-7TELM-007152628-03-0TELM-00825148-68-9TELM-009152628-02-9TELM-010114772-40-6TELM-011144702-26-1API · Telmisartan/Amlodipine Besylate/Hydrochlorothiazide
CodeCAS No.Intermediate
TELM-00118595-14-7methyl 4-amino-3-methylbenzoate
TELM-002141-75-3butyryl chloride
TELM-003301533-59-5methyl 4-butyramido-3-methylbenzoate
TELM-004152628-01-8methyl 4-butyramido-3-methyl-5-nitrobenzoate
TELM-005675882-71-0methyl 3-amino-4-butyramido-5-methylbenzoate
TELM-006152628-00-7methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate
TELM-007152628-03-04-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid
TELM-00825148-68-9-
TELM-009152628-02-91,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
TELM-010114772-40-6tert-butyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate
TELM-011144702-26-1tert-butyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
OptimisedRoute 2Steps 8 · Total yield 54.80 g
TELM-009152628-02-9TELM-01295-48-7TELM-01315174-69-3TELM-01454674-91-8TELM-015861792-67-8TELM-01695-54-5TELM-0171345840-21-2TELM-0181345840-05-2TELM-019114772-38-2TELM-020528560-93-2API · Telmisartan/Amlodipine Besylate/Hydrochlorothiazide
CodeCAS No.Intermediate
TELM-009152628-02-91,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
TELM-01295-48-7o-cresol
TELM-01315174-69-34-hydroxy-3-methylbenzaldehyde
TELM-01454674-91-84-hydroxy-3-methyl-5-nitrobenzaldehyde
TELM-015861792-67-84-methoxy-3-methyl-5-nitrobenzaldehyde
TELM-01695-54-5Availablebenzene-1,2-diamine
TELM-0171345840-21-22-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzo[d]imidazole
TELM-0181345840-05-22-methyl-4-(1-methyl-1H-benzo[d]imidazol-2-yl)-6-nitroaniline
TELM-019114772-38-2methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate
TELM-020528560-93-2methyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
OptimisedRoute 3Steps 4 · Total yield 86.7 mg
TELM-019114772-38-2TELM-02177811-44-0TELM-022123-72-8TELM-023215239-53-5TELM-02473183-34-3TELM-0251644483-28-2TELM-0261644483-28-2TELM-02749572-60-3API · Telmisartan/Amlodipine Besylate/Hydrochlorothiazide
CodeCAS No.Intermediate
TELM-019114772-38-2methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate
TELM-02177811-44-04-bromo-2-methyl-6-nitroaniline
TELM-022123-72-8butyraldehyde
TELM-023215239-53-56-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole
TELM-02473183-34-3Available4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)
TELM-0251644483-28-2-
TELM-0261644483-28-2-
TELM-02749572-60-32-bromo-1-methyl-1H-benzo[d]imidazole
OptimisedRoute 4Steps 4 · Total yield 0.20 g
TELM-009152628-02-9TELM-028114772-53-1TELM-029114772-54-2TELM-030911314-60-8TELM-031172525-90-5API · Telmisartan/Amlodipine Besylate/Hydrochlorothiazide
CodeCAS No.Intermediate
TELM-009152628-02-91,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
TELM-028114772-53-14'-methyl-[1,1'-biphenyl]-2-carbonitrile
TELM-029114772-54-24'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
TELM-030911314-60-84'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde
TELM-031172525-90-54'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carbaldehyde
OptimisedRoute 5Steps 4 · Total yield /
TELM-009152628-02-9TELM-032106-38-7TELM-033694-80-4TELM-03414385-93-4TELM-035154542-77-5TELM-0361187523-95-0API · Telmisartan/Amlodipine Besylate/Hydrochlorothiazide
CodeCAS No.Intermediate
TELM-009152628-02-91,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole
TELM-032106-38-71-bromo-4-methylbenzene
TELM-033694-80-41-bromo-2-chlorobenzene
TELM-03414385-93-42-iodo-4'-methyl-1,1'-biphenyl
TELM-035154542-77-54'-(bromomethyl)-2-iodo-1,1'-biphenyl
TELM-0361187523-95-03'-((2'-iodo-[1,1'-biphenyl]-4-yl)methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole

Frequently asked questions

What are the approved indications of Telmisartan/Amlodipine Besylate/Hydrochlorothiazide?

Approved indications include: Hypertension.

When does the Telmisartan/Amlodipine Besylate/Hydrochlorothiazide patent expire?

No public expiry year is available for Telmisartan/Amlodipine Besylate/Hydrochlorothiazide yet; this page updates once verified.

How many synthesis routes are recorded for Telmisartan/Amlodipine Besylate/Hydrochlorothiazide?

5 synthesis routes are recorded; the shortest is 4 steps with 86.7 mg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Telmisartan/Amlodipine Besylate/Hydrochlorothiazide intermediates?

2 intermediate CAS of Telmisartan/Amlodipine Besylate/Hydrochlorothiazide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Telmisartan/Amlodipine Besylate/Hydrochlorothiazide intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29