Irbesartan
Tier B — Position earlyIrbesartan
Targets：AT1
Brand：Karvea, Irbetan, Aprovel/Avapro, Aprovel/Karvea/Avapro, Avapro, Aprovel
Indications (approved)：Oesophageal disease, Hypertension, Diabetic nephropathy
Regional status
Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
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Sign in to view factories →Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-001 | 1664-35-3 | ethyl 1-aminocyclopentane-1-carboxylate |
| IRBE-002 | 999-09-7 | ethyl pentanimidate |
| IRBE-003 | 138402-05-8Available | 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one |
| IRBE-004 | 114772-54-2 | 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-005 | 138401-24-8 | 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-006 | 57598-33-1 | 2-(2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole |
| IRBE-007 | 4294-57-9 | p-tolylmagnesium bromide |
| IRBE-008 | 84392-32-5 | 4,4-dimethyl-2-(4'-methyl-[1,1'-biphenyl]-2-yl)-4,5-dihydrooxazole |
| IRBE-009 | 114772-53-1 | 4'-methyl-[1,1'-biphenyl]-2-carbonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-010 | 106-37-6Available | 1,4-dibromobenzene |
| IRBE-011 | 1122-91-4 | 4-bromobenzaldehyde |
| IRBE-012 | 873-75-6 | (4-bromophenyl)methanol |
| IRBE-013 | 589-15-1 | 1-bromo-4-(bromomethyl)benzene |
| IRBE-014 | 151257-01-1 | 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride |
| IRBE-015 | 731851-41-5 | 3-(4-bromobenzyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one |
| IRBE-016 | 144873-97-2 | (2-(1-trityl-1H-tetrazol-5-yl)phenyl)boronic acid |
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-017 | 15026-80-9 | 1-pentanamidocyclopentane-1-carboxylic acid |
| IRBE-018 | 59528-27-7 | (4-iodophenyl)methanamine hydrochloride |
| IRBE-019 | 908117-90-8 | N-(4-iodobenzyl)-1-pentanamidocyclopentane-1-carboxamide |
| IRBE-020 | 908227-87-2 | 2-butyl-3-(4-iodobenzyl)-1,3-diazaspiro[4.4]non-1-en-4-one |
| IRBE-021 | 155884-01-8 | (2-(1H-tetrazol-5-yl)phenyl)boronic acid |
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-004 | 114772-54-2 | 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-005 | 138401-24-8 | 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-022 | 17193-28-1 | 1-aminocyclopentane-1-carboxamide |
| IRBE-023 | 638-29-9 | pentanoyl chloride |
| IRBE-024 | 177219-40-8 | 1-pentanamidocyclopentane-1-carboxamide |
| IRBE-025 | 141745-71-3 | N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-1-pentanamidocyclopentane-1-carboxamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| IRBE-005 | 138401-24-8 | 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile |
| IRBE-017 | 15026-80-9 | 1-pentanamidocyclopentane-1-carboxylic acid |
| IRBE-023 | 638-29-9 | pentanoyl chloride |
| IRBE-026 | 120-92-3 | cyclopentanone |
| IRBE-027 | 49830-37-7 | 1-aminocyclopentane-1-carbonitrile |
| IRBE-028 | 92398-48-6 | 1-aminocyclopentane-1-carboxylic acid hydrochloride |
| IRBE-029 | 133690-92-3 | 4'-(aminomethyl)-[1,1'-biphenyl]-2-carbonitrile |
Frequently asked questions
What are the approved indications of Irbesartan?
Approved indications include: Oesophageal disease, Hypertension, Diabetic nephropathy.
When does the Irbesartan patent expire?
No public expiry year is available for Irbesartan yet; this page updates once verified.
How many synthesis routes are recorded for Irbesartan?
5 synthesis routes are recorded; the shortest is 3 steps with 1.83 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Irbesartan intermediates?
2 intermediate CAS of Irbesartan are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Irbesartan intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29