Metoprolol Succinate

Tier C — Watch / trade

Aralez Pharma

Originator

1985

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：ADRB1

Brand：Spesicor Dos, Toprol XL

Indications (approved)：Hypertension, Angina pectoris, Heart failure, Hyperthyroidism, Arrhythmia, Cardiac neurosis

Regional status

Approved

1992-01-10

Phase III

2021-08-18

China

Approved

1985-01-01

Japan

Synthetic routes & intermediates6 routes

Originator routes × 0Optimised (non-patent) × 5Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 2Steps 1 · Total yield /

METOPR-00456718-78-6API · Metoprolol Succinate

Code	CAS No.	Intermediate
METOPR-004	56718-78-6	3-isopropyl-5-((4-(2-methoxyethyl)phenoxy)methyl)oxazolidin-2-one

OptimisedRoute 3Steps 2 · Total yield /

METOPR-00356718-70-8METOPR-00574027-60-4API · Metoprolol Succinate

Code	CAS No.	Intermediate
METOPR-003	56718-70-8	2-((4-(2-methoxyethyl)phenoxy)methyl)oxirane
METOPR-005	74027-60-4	1-amino-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol

OptimisedRoute 4Steps 2 · Total yield /

METOPR-00156718-71-9METOPR-00623946-21-6METOPR-007—API · Metoprolol Succinate

Code	CAS No.	Intermediate
METOPR-001	56718-71-9	4-(2-methoxyethyl)phenol
METOPR-006	23946-21-6	1-(benzyl(isopropyl)amino)-3-chloropropan-2-ol
METOPR-007	-	1-(benzyl(isopropyl)amino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol

OptimisedRoute 5Steps 3 · Total yield /

METOPR-00156718-71-9METOPR-0081713-85-5METOPR-00956392-15-5METOPR-01056718-79-7API · Metoprolol Succinate

Code	CAS No.	Intermediate
METOPR-001	56718-71-9	4-(2-methoxyethyl)phenol
METOPR-008	1713-85-5	3-chloro-2-hydroxypropanoic acid
METOPR-009	56392-15-5	2-hydroxy-3-(4-(2-methoxyethyl)phenoxy)propanoic acid
METOPR-010	56718-79-7	2-hydroxy-N-isopropyl-3-(4-(2-methoxyethyl)phenoxy)propanamide

OptimisedRoute 6Steps 2 · Total yield 0.62 g

METOPR-00156718-71-9METOPR-011106-95-6METOPR-01280448-05-1API · Metoprolol Succinate

Code	CAS No.	Intermediate
METOPR-001	56718-71-9	4-(2-methoxyethyl)phenol
METOPR-011	106-95-6 Available	3-bromoprop-1-ene
METOPR-012	80448-05-1	1-(allyloxy)-4-(2-methoxyethyl)benzene

ProcessRoute 1Steps 2 · Total yield 1.2 kg

METOPR-00156718-71-9METOPR-002106-89-8METOPR-00356718-70-8Metoprolol51384-51-1API · Metoprolol Succinate

Code	CAS No.	Intermediate
METOPR-001	56718-71-9	4-(2-methoxyethyl)phenol
METOPR-002	106-89-8	2-(chloromethyl)oxirane
METOPR-003	56718-70-8	2-((4-(2-methoxyethyl)phenoxy)methyl)oxirane
Metoprolol	51384-51-1	1-(isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol

Frequently asked questions

What are the approved indications of Metoprolol Succinate?

Approved indications include: Hypertension, Angina pectoris, Heart failure, Hyperthyroidism, Arrhythmia, Cardiac neurosis.

When does the Metoprolol Succinate patent expire?

No public expiry year is available for Metoprolol Succinate yet; this page updates once verified.

How many synthesis routes are recorded for Metoprolol Succinate?

6 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Metoprolol Succinate intermediates?

1 intermediate CAS of Metoprolol Succinate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Metoprolol Succinate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29