Ioflupane (123I)

Tier C — Watch / trade

Ioflupane (123I)

Ge Healthcare

Originator

2000

First approval

Expiry (public)

No sales data

Peak sales

Radiopharmaceutical

Type

Targets：Not applicable

Brand：DaTSCAN, Striascan

Indications (approved)：Lewy body dementia, Diagnostic agent, Parkinsonism, Alzheimer's disease, Parkinson's disease

Regional status

Approved

2011-01-14

Approved

2000-07-27

China

Phase III

2020-06-28

Japan

Approved

2013-09-20

Synthetic routes & intermediates3 routes

Originator routes × 0Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 4 · Total yield /

Ioflupane (123I)-001—Ioflupane (123I)-002—Ioflupane (123I)-003352-91-0Ioflupane (123I)-004—Ioflupane (123I)-005155798-00-8API · Ioflupane (123I)

Code	CAS No.	Intermediate
Ioflupane (123I)-001	-	Methyl(2S,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-002	-	Methyl(2S,3S)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-003	352-91-0	1-Bromo-3-fluoropropane
Ioflupane (123I)-004	-	Methyl(2S,3S)-8-(3-fluoropropyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-005	155798-00-8	Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate

OptimisedRoute 2Steps 8 · Total yield /

Ioflupane (123I)-006532-24-1Ioflupane (123I)-007616-38-6Ioflupane (123I)-00867-56-1Ioflupane (123I)-00936127-17-0Ioflupane (123I)-010106293-60-1Ioflupane (123I)-011127379-24-2Ioflupane (123I)-012106-37-6Ioflupane (123I)-013135367-08-7Ioflupane (123I)-014189950-17-2Ioflupane (123I)-003352-91-0Ioflupane (123I)-015343312-15-2Ioflupane (123I)-005155798-00-8API · Ioflupane (123I)

Code	CAS No.	Intermediate
Ioflupane (123I)-006	532-24-1	8-Methyl-8-azabicyclo[3.2.1]octan-3-one
Ioflupane (123I)-007	616-38-6	Carbonicaciddimethyldiester
Ioflupane (123I)-008	67-56-1 Available	Hydroxymethane
Ioflupane (123I)-009	36127-17-0	Methyl8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-010	106293-60-1	Methyl3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-011	127379-24-2	Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate
Ioflupane (123I)-012	106-37-6 Available	1,4-Dibromobenzene
Ioflupane (123I)-013	135367-08-7	(±)-Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-014	189950-17-2	(±)-Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-003	352-91-0	1-Bromo-3-fluoropropane
Ioflupane (123I)-015	343312-15-2	Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-005	155798-00-8	Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate

OptimisedRoute 3Steps 6 · Total yield /

Ioflupane (123I)-0161933755-75-9Ioflupane (123I)-017—Ioflupane (123I)-011127379-24-2Ioflupane (123I)-018100-58-3Ioflupane (123I)-019—Ioflupane (123I)-001—Ioflupane (123I)-020—Ioflupane (123I)-021—API · Ioflupane (123I)

Code	CAS No.	Intermediate
Ioflupane (123I)-016	1933755-75-9	Methyl(2R,3S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-017	-	Methyl(2R,3S)-3-(benzyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-011	127379-24-2	Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate
Ioflupane (123I)-018	100-58-3	Bromo(phenyl)magnesium
Ioflupane (123I)-019	-	Methyl(2S,3S)-8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-001	-	Methyl(2S,3S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-020	-	Methyl(2S,3S)-8-methyl-3-[4-(tributylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate
Ioflupane (123I)-021	-	Methyl(2S,3S)-3-[4-[123I]iodophenyl]-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Frequently asked questions

What are the approved indications of Ioflupane (123I)?

Approved indications include: Lewy body dementia, Diagnostic agent, Parkinsonism, Alzheimer's disease, Parkinson's disease.

When does the Ioflupane (123I) patent expire?

No public expiry year is available for Ioflupane (123I) yet; this page updates once verified.

How many synthesis routes are recorded for Ioflupane (123I)?

3 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ioflupane (123I) intermediates?

2 intermediate CAS of Ioflupane (123I) are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ioflupane (123I) intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29