Gefapixant Citrate
Tier C — Watch / tradeGefapixant Citrate
Targets：P2RX3
Brand：Lyfnua
Indications (approved)：Cough
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| GEFAP-001 | 705-15-7 | 1-(2-hydroxy-5-methoxyphenyl)ethanone |
| GEFAP-002 | 13522-86-6 | 2-isopropyl-4-methoxyphenol |
| GEFAP-003 | 927872-64-8 | 2-(2-isopropyl-4-methoxyphenoxy)acetonitrile |
| GEFAP-004 | 5815-08-7 | 1-tert-butoxy-N,N,N',N'-tetramethylmethanediamine |
| GEFAP-005 | 927887-19-2 | 3,3-bis(dimethylamino)-2-(2-isopropyl-4-methoxyphenoxy)propanenitrile |
| GEFAP-006 | 927887-20-5 | (E)-2-(2-isopropyl-4-methoxyphenoxy)-3-(phenylamino)acrylonitrile |
| GEFAP-007 | - | 5-(2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine |
| GEFAP-008 | - | 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonic acid |
| GEFAP-009 | - | 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonyl chloride |
| GEFAP-010 | - | 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide compound with tetrahydrothiophene 1,1-dioxide (1:1) |
Frequently asked questions
What are the approved indications of Gefapixant Citrate?
Approved indications include: Cough.
When does the Gefapixant Citrate patent expire?
No public expiry year is available for Gefapixant Citrate yet; this page updates once verified.
How many synthesis routes are recorded for Gefapixant Citrate?
1 synthesis routes are recorded; the shortest is 9 steps with 8.17 kg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Gefapixant Citrate intermediates?
All intermediates in Gefapixant Citrate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Gefapixant Citrate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29