Perampanel Hydrate
Tier C — Watch / tradePerampanel Hydrate · all drugs expiring in 2028 →
Targets：AMPAR
Brand：Fycompa
Indications (approved)：Tonic-clonic seizure, Partial-onset seizure, Epilepsy, Seizure
Regional status
Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
1 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| PERAM-001 | 1072-97-5 | 5-bromopyridin-2-amine |
| PERAM-002 | 381233-96-1 | 5-bromo-3-iodopyridin-2-amine |
| PERAM-003 | 381233-75-6 | 5-bromo-3-iodopyridin-2(1H)-one |
| PERAM-004 | 98-80-6 | phenylboronic acid |
| PERAM-005 | 381233-76-7 | 5-bromo-3-iodo-1-phenylpyridin-2(1H)-one |
| PERAM-006 | 172732-52-4 | 2-(1,3,2-dioxaborinan-2-yl)benzonitrile |
| PERAM-007 | 381233-77-8 | 2-(5-bromo-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile |
| PERAM-008 | 381250-74-4 | 2-(2-oxo-1-phenyl-5-(tributylstannyl)-1,2-dihydropyridin-3-yl)benzonitrile |
| PERAM-009 | 109-09-1 | 2-chloropyridine |
| Code | CAS No. | Intermediate |
|---|---|---|
| PERAM-004 | 98-80-6 | phenylboronic acid |
| PERAM-006 | 172732-52-4 | 2-(1,3,2-dioxaborinan-2-yl)benzonitrile |
| PERAM-010 | 624-28-2 | 2,5-dibromopyridine |
| PERAM-011 | 13472-85-0 | 5-bromo-2-methoxypyridine |
| PERAM-012 | 17997-47-6 | 2-(tributylstannyl)pyridine |
| PERAM-013 | 381725-49-1 | 6'-methoxy-2,3'-bipyridine |
| PERAM-014 | 381233-78-9 | [2,3'-bipyridin]-6'(1'H)-one |
| PERAM-015 | 381233-79-0 | 5'-bromo-[2,3'-bipyridin]-6'(1'H)-one |
| PERAM-016 | 381248-05-1 | 5'-bromo-6'-methoxy-2,3'-bipyridine |
| PERAM-017 | 380917-95-3 | 2-(6'-methoxy-[2,3'-bipyridin]-5'-yl)benzonitrile |
| PERAM-018 | 380917-96-4 | 2-(6'-oxo-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| PERAM-006 | 172732-52-4 | 2-(1,3,2-dioxaborinan-2-yl)benzonitrile |
| PERAM-011 | 13472-85-0 | 5-bromo-2-methoxypyridine |
| PERAM-013 | 381725-49-1 | 6'-methoxy-2,3'-bipyridine |
| PERAM-014 | 381233-78-9 | [2,3'-bipyridin]-6'(1'H)-one |
| PERAM-019 | 1628-89-3 | 2-methoxypyridine |
| PERAM-020 | 24244-60-8 | 2-(phenylsulfonyl)pyridine |
| PERAM-021 | 381725-50-4 | 1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one |
| PERAM-022 | 381248-06-2 | 5'-bromo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| PERAM-025 | 914918-74-4 | 5-acetyl-1-phenylpyridin-2(1H)-one |
| PERAM-026 | 1622863-49-3 | 5-acetyl-3-bromo-1-phenylpyridin-2(1H)-one |
| PERAM-027 | 214360-79-9 | 2-(1,3,2-dioxaborolan-2-yl)benzonitrile |
| PERAM-028 | 1622863-50-6 | 2-(5-acetyl-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile |
| PERAM-029 | 927-63-9 | (E)-3-(dimethylamino)acrylaldehyde |
| PERAM-004 | 98-80-6 | phenylboronic acid |
| PERAM-023 | 55676-22-7 | 1-(6-chloropyridin-3-yl)ethanone |
| PERAM-024 | 1124-29-4 | 5-acetylpyridin-2(1H)-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| PERAM-030 | 18698-99-2 | 2-(2-cyanophenyl)acetic acid |
| PERAM-031 | 62-53-3Available | aniline |
| PERAM-032 | 71732-86-0 | 2-(2-cyanophenyl)-N-phenylacetamide |
| PERAM-033 | 1646529-95-4 | - |
| PERAM-034 | 16179-97-8 | 2-(pyridin-2-yl)acetic acid hydrochloride |
Frequently asked questions
What are the approved indications of Perampanel Hydrate?
Approved indications include: Tonic-clonic seizure, Partial-onset seizure, Epilepsy, Seizure.
When does the Perampanel Hydrate patent expire?
Based on public sources, the Perampanel Hydrate patent expires in 2028.
How many synthesis routes are recorded for Perampanel Hydrate?
5 synthesis routes are recorded; the shortest is 3 steps with 17.7 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Perampanel Hydrate intermediates?
1 intermediate CAS of Perampanel Hydrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Perampanel Hydrate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29