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Cipargamin
Tier C — Watch / tradeCipargamin
Novartis
Originator
-
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：PfATP4
Indications (approved)：Falciparum malaria, Plasmodium infection
Regional status
US
-
EU
No progress
2020-07-22
China
-
Japan
-
Synthetic routes & intermediates4 routes
Originator routes × 1Optimised (non-patent) × 3Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 13 · Total yield 10.8 g
CIPARG-00117630-76-1CIPARG-002879563-65-2CIPARG-00317366-80-2CIPARG-0041809076-21-8CIPARG-0051809076-20-7CIPARG-0061809076-22-9CIPARG-0071809076-23-0CIPARG-0081809076-24-1CIPARG-0091809076-25-2CIPARG-0101809076-26-3CIPARG-0111809076-27-4CIPARG-0121809076-28-5CIPARG-0131809076-29-6CIPARG-0141809076-30-9CIPARG-015143101-26-2Cipargamin1193314-23-6API · Cipargamin
| Code | CAS No. | Intermediate |
|---|---|---|
| CIPARG-001 | 17630-76-1 | 5-chloroindoline-2,3-dione |
| CIPARG-002 | 879563-65-2 | 5-chloro-1-(4-methoxybenzyl)indoline-2,3-dione |
| CIPARG-003 | 17366-80-2 | P,P-diphenylphosphinothioic amide |
| CIPARG-004 | 1809076-21-8 | (E)-N-(5-chloro-1-(4-methoxybenzyl)-2-oxoindolin-3-ylidene)-P,P-diphenylphosphinothioic amide |
| CIPARG-005 | 1809076-20-7 | tert-butyl (5-chloro-2-ethynyl-4-fluorophenyl)carbamate |
| CIPARG-006 | 1809076-22-9 | tert-butyl (S)-(5-chloro-2-((5-chloro-3-((diphenylphosphorothioyl)amino)-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)ethynyl)-4-fluorophenyl)carbamate |
| CIPARG-007 | 1809076-23-0 | (S)-N-(3-((2-amino-4-chloro-5-fluorophenyl)ethynyl)-5-chloro-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-P,P-diphenylphosphinothioic amide |
| CIPARG-008 | 1809076-24-1 | (R)-N-(5-chloro-3-(6-chloro-5-fluoro-1H-indol-2-yl)-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)-P,P-diphenylphosphinothioic amide |
| CIPARG-009 | 1809076-25-2 | (R)-3-amino-5-chloro-3-(6-chloro-5-fluoro-1H-indol-2-yl)-1-(4-methoxybenzyl)indolin-2-one |
| CIPARG-010 | 1809076-26-3 | benzyl (R)-(5-chloro-3-(6-chloro-5-fluoro-1H-indol-2-yl)-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)carbamate |
| CIPARG-011 | 1809076-27-4 | benzyl (R)-(5-chloro-3-(6-chloro-5-fluoro-3-formyl-1H-indol-2-yl)-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)carbamate |
| CIPARG-012 | 1809076-28-5 | benzyl (R,E)-(5-chloro-3-(6-chloro-5-fluoro-3-(2-nitroprop-1-en-1-yl)-1H-indol-2-yl)-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)carbamate |
| CIPARG-013 | 1809076-29-6 | benzyl (R)-(5-chloro-3-(6-chloro-5-fluoro-3-(2-oxopropyl)-1H-indol-2-yl)-1-(4-methoxybenzyl)-2-oxoindolin-3-yl)carbamate |
| CIPARG-014 | 1809076-30-9 | (3R,3'S)-5,7'-dichloro-6'-fluoro-1-(4-methoxybenzyl)-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one |
| CIPARG-015 | 143101-26-2 | 5-chloro-2-ethynyl-4-fluoroaniline |
| Cipargamin | 1193314-23-6 | (3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one |
OptimisedRoute 2Steps 10 · Total yield 15 mg
CIPARG-020—CIPARG-0211193314-78-1CIPARG-0221193314-79-2CIPARG-0231193314-80-5CIPARG-0241193314-81-6CIPARG-0251193314-86-1Cipargamin1193314-23-6CIPARG-00117630-76-1CIPARG-016122509-72-2CIPARG-0171193314-76-9CIPARG-0181193314-77-0CIPARG-0192007920-27-4API · Cipargamin
| Code | CAS No. | Intermediate |
|---|---|---|
| CIPARG-020 | - | methyl (R)-2-amino-3-(6-chloro-5-fluoro-1H-indol-3-yl)propanoate |
| CIPARG-021 | 1193314-78-1 | methyl (R)-2-((tert-butoxycarbonyl)amino)-3-(6-chloro-5-fluoro-1H-indol-3-yl)propanoate |
| CIPARG-022 | 1193314-79-2 | tert-butyl (R)-(1-(6-chloro-5-fluoro-1H-indol-3-yl)-3-hydroxypropan-2-yl)carbamate |
| CIPARG-023 | 1193314-80-5 | (R)-2-((tert-butoxycarbonyl)amino)-3-(6-chloro-5-fluoro-1H-indol-3-yl)propyl methanesulfonate |
| CIPARG-024 | 1193314-81-6 | tert-butyl (S)-(1-(6-chloro-5-fluoro-1H-indol-3-yl)propan-2-yl)carbamate |
| CIPARG-025 | 1193314-86-1 | (S)-1-(6-chloro-5-fluoro-1H-indol-3-yl)propan-2-amine |
| Cipargamin | 1193314-23-6 | (3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one |
| CIPARG-001 | 17630-76-1 | 5-chloroindoline-2,3-dione |
| CIPARG-016 | 122509-72-2 | 6-chloro-5-fluoro-1H-indole |
| CIPARG-017 | 1193314-76-9 | 2-acetamido-3-(6-chloro-5-fluoro-1H-indol-3-yl)propanoic acid |
| CIPARG-018 | 1193314-77-0 | (R)-2-acetamido-3-(6-chloro-5-fluoro-1H-indol-3-yl)propanoic acid |
| CIPARG-019 | 2007920-27-4 | (R)-2-amino-3-(6-chloro-5-fluoro-1H-indol-3-yl)propanoic acid |
OptimisedRoute 3Steps 6 · Total yield 26.23 g
CIPARG-00117630-76-1CIPARG-02696202-57-2CIPARG-0271458665-06-9CIPARG-0281458665-07-0CIPARG-0291458665-08-1CIPARG-030—CIPARG-031—Cipargamin1193314-23-6API · Cipargamin
| Code | CAS No. | Intermediate |
|---|---|---|
| CIPARG-001 | 17630-76-1 | 5-chloroindoline-2,3-dione |
| CIPARG-026 | 96202-57-2 | 6-chloro-5-fluoroindoline-2,3-dione |
| CIPARG-027 | 1458665-06-9 | 6-chloro-5-fluoro-3-hydroxy-3-(2-oxopropyl)indolin-2-one |
| CIPARG-028 | 1458665-07-0 | 6-chloro-5-fluoro-3-hydroxy-3-((2-methyl-1,3-dioxolan-2-yl)methyl)indolin-2-one |
| CIPARG-029 | 1458665-08-1 | 1-(6-chloro-5-fluoro-1H-indol-3-yl)propan-2-one |
| CIPARG-030 | - | (S)-1-(6-chloro-5-fluoro-1H-indol-3-yl)propan-2-amine (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid |
| CIPARG-031 | - | (3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid |
| Cipargamin | 1193314-23-6 | (3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one |
OptimisedRoute 4Steps 5 · Total yield /
CIPARG-00117630-76-1CIPARG-016122509-72-2CIPARG-032467451-99-6CIPARG-0331458665-11-6CIPARG-0341193314-75-8CIPARG-0351193314-69-0Cipargamin1193314-23-6API · Cipargamin
| Code | CAS No. | Intermediate |
|---|---|---|
| CIPARG-001 | 17630-76-1 | 5-chloroindoline-2,3-dione |
| CIPARG-016 | 122509-72-2 | 6-chloro-5-fluoro-1H-indole |
| CIPARG-032 | 467451-99-6 | 6-chloro-5-fluoro-1H-indole-3-carbaldehyde |
| CIPARG-033 | 1458665-11-6 | (Z)-6-chloro-5-fluoro-3-(2-nitroprop-1-en-1-yl)-1H-indole |
| CIPARG-034 | 1193314-75-8 | 1-(6-chloro-5-fluoro-1H-indol-3-yl)propan-2-amine |
| CIPARG-035 | 1193314-69-0 | 5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one |
| Cipargamin | 1193314-23-6 | (3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one |
Frequently asked questions
What are the approved indications of Cipargamin?
Approved indications include: Falciparum malaria, Plasmodium infection.
When does the Cipargamin patent expire?
No public expiry year is available for Cipargamin yet; this page updates once verified.
How many synthesis routes are recorded for Cipargamin?
4 synthesis routes are recorded; the shortest is 5 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Cipargamin intermediates?
All intermediates in Cipargamin routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Cipargamin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-18