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Betamethasone

Tier C — Watch / trade

Betamethasone

MSD (Merck Sharp & Dohme)
Originator
1961
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets:GR

Brand:Rinderon, Celestone

Indications (approved):Ulcerative proctitis, Hypersensitivity reaction, Rheumatoid arthritis, Cutaneous lupus erythematosus, Dermatitis, Asthma, Inflammatory disease

Regional status

US
Phase III
2010-10-01
EU
-
China
Approved
1981-01-01
Japan
Approved
1981-09-01

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates1 routes

Originator routes × 0Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 6 · Total yield 80g(Betamethasone-005)
Betamethasone-001560-62-3Betamethasone-00275-86-5Betamethasone-003116256-35-0Betamethasone-004116256-45-2Betamethasone-00563561-93-3Betamethasone-006173350-25-9Betamethasone-007—Betamethasone-008676-58-4Betamethasone-009—API · Betamethasone
CodeCAS No.Intermediate
Betamethasone-001560-62-39-Hydroxyandrost-4-ene-3,17-dione
Betamethasone-00275-86-52-Hydroxy-2-methylpropanenitrile
Betamethasone-003116256-35-0(17alpha)-9,17-Dihydroxy-3-oxoandrost-4-ene-17-carbonitrile
Betamethasone-004116256-45-2(8S,9R,10S,13S,14S,17R)-9,17-Dihydroxy-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-17-carbonitrile
Betamethasone-00563561-93-3(16beta)-17-Hydroxy-16-methylpregna-4,9(11)-diene-3,20-dione
Betamethasone-006173350-25-9(8S,10S,13S,14S)-10,13-Dimethyl-1,2,4,7,8,10,12,13,14,15-decahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane]-17-carbonitrile
Betamethasone-007-(4'aS,6'aS,6'bR,7'aR,8'aS,8'bS)-4'a,6'a-Dimethyl-3',4',4'a,6',6'a,7'a,8',8'a,8'b,9'-decahydrospiro[1,3-dioxolane-2,2'-naphtho[2',1':4,5]indeno[1,2-b]oxirene]-6'b(1'H)-carbonitrile
Betamethasone-008676-58-4Methylmagnesium chloride
Betamethasone-009-1-[(8S,10S,13S,14S,16S,17R)-17-Hydroxy-10,13,16-trimethyl-1,2,6,7,8,10,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl]ethan-1-one

Frequently asked questions

What are the approved indications of Betamethasone?

Approved indications include: Ulcerative proctitis, Hypersensitivity reaction, Rheumatoid arthritis, Cutaneous lupus erythematosus, Dermatitis, Asthma, Inflammatory disease.

When does the Betamethasone patent expire?

No public expiry year is available for Betamethasone yet; this page updates once verified.

How many synthesis routes are recorded for Betamethasone?

1 synthesis routes are recorded; the shortest is 6 steps with 80g(Betamethasone-005) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Betamethasone intermediates?

All intermediates in Betamethasone routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Betamethasone intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29