Miltefosine

Tier C — Watch / trade

Miltefosine

Originator

2002

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：Not applicable

Brand：Miltex, Impavido, Miltefosin

Indications (approved)：利什曼原虫感染

Regional status

Approved

2014-03-19

Discontinued

2008-09-01

China

Japan

Synthetic routes & intermediates5 routes

Originator routes × 0Optimised (non-patent) × 5Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 1 · Total yield /

Miltefosine-001645-84-1Miltefosine-002—Miltefosine-003112-82-3API · Miltefosine

Code	CAS No.	Intermediate
Miltefosine-001	645-84-1	[2-(Trimethylaminio)ethyl] hydrogen phosphate
Miltefosine-002	-	[2-(trimethylazaniumyl)ethyl] hydrogen phosphate
Miltefosine-003	112-82-3	1-Bromohexadecane

OptimisedRoute 2Steps 4 · Total yield /

Miltefosine-00436653-82-4Miltefosine-00558527-29-0Miltefosine-00671321-34-1Miltefosine-007—Miltefosine-008141-43-5API · Miltefosine

Code	CAS No.	Intermediate
Miltefosine-004	36653-82-4	1-Hexadecanol
Miltefosine-005	58527-29-0	(Hexadecyloxy)phosphonoyl dichloride
Miltefosine-006	71321-34-1	2-(Hexadecyloxy)-1,3,2-oxazaphospholidin-2-one
Miltefosine-007	-	hexadecyl propyl phosphate
Miltefosine-008	141-43-5 Available	1-Amino-2-hydroxyethane

OptimisedRoute 3Steps 2 · Total yield /

Miltefosine-00436653-82-4Miltefosine-0096609-64-9Miltefosine-010146556-18-5API · Miltefosine

Code	CAS No.	Intermediate
Miltefosine-004	36653-82-4	1-Hexadecanol
Miltefosine-009	6609-64-9	2-Chloro-1,3-dioxaphospholan-2-one
Miltefosine-010	146556-18-5	2-(hexadecyloxy)-1,3,2-dioxaphospholan-2-one

OptimisedRoute 4Steps 3 · Total yield 1.65g(Miltefosine (Free))

Miltefosine-00436653-82-4Miltefosine-011822-39-9Miltefosine-012216437-33-1Miltefosine-013216437-34-2Miltefosine-01475-50-3API · Miltefosine

Code	CAS No.	Intermediate
Miltefosine-004	36653-82-4	1-Hexadecanol
Miltefosine-011	822-39-9	2-Chloro-1,3,2-dioxaphospholane
Miltefosine-012	216437-33-1	2-(hexadecyloxy)-1,3,2-dioxaphospholane
Miltefosine-013	216437-34-2	(2-bromoethyl) hexadecyl bromophosphonate
Miltefosine-014	75-50-3	Dimethylamino methane

OptimisedRoute 5Steps 4 · Total yield /

Miltefosine-015109-78-4Miltefosine-01676101-30-9Miltefosine-017108-18-9Miltefosine-018102691-36-1Miltefosine-01975667-82-2Miltefosine-0202365519-55-5Miltefosine-00436653-82-4API · Miltefosine

Code	CAS No.	Intermediate
Miltefosine-015	109-78-4 Available	1-Cyano-2-hydroxyethane
Miltefosine-016	76101-30-9	2-Cyanoethyl phosphorodichloridoite
Miltefosine-017	108-18-9	Bis(isopropyl)amine
Miltefosine-018	102691-36-1	2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidoite
Miltefosine-019	75667-82-2	2-Hydroxy-N,N,N-trimethylethan-1-aminium tetraphenylborate(1-)
Miltefosine-020	2365519-55-5	2-([(2-Cyanoethoxy)[di(propan-2-yl)amino]phosphanyl]oxy)-N,N,N-trimethylethan-1-aminium tetraphenylborate(1-)
Miltefosine-004	36653-82-4	1-Hexadecanol

Frequently asked questions

What are the approved indications of Miltefosine?

Approved indications include: 利什曼原虫感染.

When does the Miltefosine patent expire?

No public expiry year is available for Miltefosine yet; this page updates once verified.

How many synthesis routes are recorded for Miltefosine?

5 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Miltefosine intermediates?

2 intermediate CAS of Miltefosine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Miltefosine intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29