Asengeprast
Tier C — Watch / tradeAsengeprast
Targets：TGF-β, PDGFB, GPR68
Indications (approved)：弥漫性硬皮病, Systemic sclerosis
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| SHP-627 | 1001288-58-9 | (E)-2-(3-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)acrylamido)benzoic acid |
| SHP-627-001 | 121-33-5Available | 4-hydroxy-3-methoxybenzaldehyde |
| SHP-627-002 | 106-96-7 | 3-bromoprop-1-yne |
| SHP-627-003 | 5651-83-2 | 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde |
| SHP-627-004 | 53947-84-5 | 2-(2-carboxyacetamido)benzoic acid |
| SHP-627-005 | 118-92-3 | 2-aminobenzoic acid |
| SHP-627-006 | 2033-24-1 | 2,2-dimethyl-1,3-dioxane-4,6-dione |
Frequently asked questions
What are the approved indications of Asengeprast?
Approved indications include: 弥漫性硬皮病, Systemic sclerosis.
When does the Asengeprast patent expire?
No public expiry year is available for Asengeprast yet; this page updates once verified.
How many synthesis routes are recorded for Asengeprast?
1 synthesis routes are recorded; the shortest is 3 steps with 222 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Asengeprast intermediates?
1 intermediate CAS of Asengeprast are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Asengeprast intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-21