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Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline

Tier C — Watch / trade

Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline

Astellas Pharma Inc.
Originator
2018
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets:DPP4, SGLT2

Brand:Sujanu

Indications (approved):Type 2 diabetes

Regional status

US
-
EU
-
China
-
Japan
Approved
2018-03-23

Factories producing this API19

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 63 mg
IPRA-00193777-26-5IPRA-00295-15-8IPRA-0031034305-11-7IPRA-004761424-75-3IPRA-00513096-62-3IPRA-006—IPRA-007761425-14-3IPRA-008761423-01-2API · Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline
CodeCAS No.Intermediate
IPRA-00193777-26-5Available5-bromo-2-fluorobenzaldehyde
IPRA-00295-15-8benzo[b]thiophene
IPRA-0031034305-11-7Availablebenzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol
IPRA-004761424-75-3(benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methoxy)(tert-butyl)dimethylsilane
IPRA-00513096-62-3Available(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one
IPRA-006-(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl((tert-butyldimethylsilyl)oxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
IPRA-007761425-14-3(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl(hydroxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
IPRA-008761423-01-2(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran
OptimisedRoute 2Steps 5 · Total yield /
IPRA-00193777-26-5IPRA-00295-15-8IPRA-0031034305-11-7IPRA-00513096-62-3IPRA-008761423-01-2IPRA-0091034305-17-3IPRA-010—API · Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline
CodeCAS No.Intermediate
IPRA-00193777-26-5Available5-bromo-2-fluorobenzaldehyde
IPRA-00295-15-8benzo[b]thiophene
IPRA-0031034305-11-7Availablebenzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol
IPRA-00513096-62-3Available(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one
IPRA-008761423-01-2(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran
IPRA-0091034305-17-3Available2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene
IPRA-010-(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
OptimisedRoute 4Steps 1 · Total yield 3.58 g
IPRA-0091034305-17-3IPRA-01774372-90-0IPRA-0181825379-70-1API · Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline
CodeCAS No.Intermediate
IPRA-0091034305-17-3Available2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene
IPRA-01774372-90-0(1S,3R,4R,5S,6R)-4,5-bis(benzyloxy)-3-((benzyloxy)methyl)-2,7-dioxabicyclo[4.1.0]heptane
IPRA-0181825379-70-1(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-ol
ProcessRoute 3Steps 8 · Total yield 1.7 g
IPRA-00193777-26-5IPRA-00295-15-8IPRA-0031034305-11-7IPRA-0091034305-17-3IPRA-0111034305-19-5IPRA-01232384-65-9IPRA-0131034305-23-1IPRA-0141034305-27-5IPRA-0151034305-21-9IPRA-016147-85-3API · Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline
CodeCAS No.Intermediate
IPRA-00193777-26-5Available5-bromo-2-fluorobenzaldehyde
IPRA-00295-15-8benzo[b]thiophene
IPRA-0031034305-11-7Availablebenzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol
IPRA-0091034305-17-3Available2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene
IPRA-0111034305-19-52-((5-bromo-2-fluorophenyl)chloromethyl)benzo[b]thiophene
IPRA-01232384-65-9Available(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
IPRA-0131034305-23-1(2S,3R,4S,5S,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
IPRA-0141034305-27-5(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate
IPRA-0151034305-21-9Available(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
IPRA-016147-85-3(S)-pyrrolidine-2-carboxylic acid

Frequently asked questions

What are the approved indications of Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline?

Approved indications include: Type 2 diabetes.

When does the Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline patent expire?

No public expiry year is available for Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline yet; this page updates once verified.

How many synthesis routes are recorded for Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline?

4 synthesis routes are recorded; the shortest is 1 steps with 3.58 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline intermediates?

6 intermediate CAS of Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29