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Oxymetazoline Hydrochloride/Tetracaine Hydrochloride
Tier C — Watch / tradeOxymetazoline Hydrochloride/Tetracaine Hydrochloride
St. Renatus Llc
Originator
2016
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：ADRA1A
Brand：Kovanaze
Indications (approved)：Anaesthesia
Regional status
US
Approved
2016-06-29
EU
-
China
-
Japan
-
Factories producing this API9
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
9 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates7 routes
Originator routes × 0Optimised (non-patent) × 7Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 5 · Total yield 7.5g(Oxymetazoline hydrochloride (API))
Oxymetazoline Hydrochloride-001—Oxymetazoline Hydrochloride-002107-30-2Oxymetazoline Hydrochloride-00323500-79-0Oxymetazoline Hydrochloride-00455699-10-0Oxymetazoline Hydrochloride-0051191945-77-3Oxymetazoline Hydrochloride-0061491-59-4Oxymetazoline Hydrochloride-00755699-13-3Oxymetazoline Hydrochloride-00814034-59-4Oxymetazoline Hydrochloride-00943702-89-2API · Oxymetazoline Hydrochloride/Tetracaine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Oxymetazoline Hydrochloride-001 | - | 4-tert-Butyl-2,6-dimethylbenzene-1,3-diol |
| Oxymetazoline Hydrochloride-002 | 107-30-2Available | 1-Chloro-1-methoxymethane |
| Oxymetazoline Hydrochloride-003 | 23500-79-0 | 6-tert-Butyl-3-(chloromethyl)-2,4-dimethylphenol |
| Oxymetazoline Hydrochloride-004 | 55699-10-0 | (4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile |
| Oxymetazoline Hydrochloride-005 | 1191945-77-3 | 4,5-Dihydro-1H-imidazole-2-thiol |
| Oxymetazoline Hydrochloride-006 | 1491-59-4 | 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol |
| Oxymetazoline Hydrochloride-007 | 55699-13-3 | 2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide |
| Oxymetazoline Hydrochloride-008 | 14034-59-4 | Ethane-1,2-diamine 4-methylbenzenesulfonate |
| Oxymetazoline Hydrochloride-009 | 43702-89-2 | Ethane-1,2-diamine hydrobromide |
OptimisedRoute 2Steps 6 · Total yield 26g(Oxymetazoline hydrochloride (API))
Oxymetazoline Hydrochloride-00455699-10-0Oxymetazoline Hydrochloride-010107-15-3Oxymetazoline Hydrochloride-011871-78-3Oxymetazoline Hydrochloride-0061491-59-4Oxymetazoline Hydrochloride-01255699-17-7Oxymetazoline Hydrochloride-01355699-12-2Oxymetazoline Hydrochloride-00814034-59-4Oxymetazoline Hydrochloride-00755699-13-3Oxymetazoline Hydrochloride-0142576-47-8Oxymetazoline Hydrochloride-015106-93-4Oxymetazoline Hydrochloride-016—API · Oxymetazoline Hydrochloride/Tetracaine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Oxymetazoline Hydrochloride-004 | 55699-10-0 | (4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile |
| Oxymetazoline Hydrochloride-010 | 107-15-3 | Ethane-1,2-diamine |
| Oxymetazoline Hydrochloride-011 | 871-78-3 | N-[2-(Acetamido)ethyl]acetamide |
| Oxymetazoline Hydrochloride-006 | 1491-59-4 | 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol |
| Oxymetazoline Hydrochloride-012 | 55699-17-7 | (4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetyl chloride |
| Oxymetazoline Hydrochloride-013 | 55699-12-2 | (4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetic acid |
| Oxymetazoline Hydrochloride-008 | 14034-59-4 | Ethane-1,2-diamine 4-methylbenzenesulfonate |
| Oxymetazoline Hydrochloride-007 | 55699-13-3 | 2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide |
| Oxymetazoline Hydrochloride-014 | 2576-47-8 | 2-Bromoethanamine hydrobromide |
| Oxymetazoline Hydrochloride-015 | 106-93-4Available | Ethylene dibromide |
| Oxymetazoline Hydrochloride-016 | - | Ethyl 2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)ethanimidoate hydrochloride |
OptimisedRoute 1Steps 6 · Total yield /
Tetracaine-00162-23-7Tetracaine-002122-04-3Tetracaine-003108-01-0Tetracaine-00454288-75-4Tetracaine-00538152-22-6Tetracaine-00617599-02-9Tetracaine-00710012-47-2Tetracaine-008123-72-8Tetracaine-009109-65-9Tetracaine-01094-24-6API · Oxymetazoline Hydrochloride/Tetracaine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Tetracaine-001 | 62-23-7 | 4-Nitrobenzoic acid |
| Tetracaine-002 | 122-04-3 | 4-Nitrobenzoyl chloride |
| Tetracaine-003 | 108-01-0 | N,N-Dimethylaminoethanol |
| Tetracaine-004 | 54288-75-4 | 2-(Dimethylamino)ethyl 4-nitrobenzoate hydrogen chloride |
| Tetracaine-005 | 38152-22-6 | 2-(Dimethylamino)ethyl 4-nitrobenzoate |
| Tetracaine-006 | 17599-02-9 | 2-(Dimethylamino)ethyl 4-aminobenzoate hydrogen chloride |
| Tetracaine-007 | 10012-47-2 | 4-Aminobenzoic acid 2-(dimethylamino)ethyl ester |
| Tetracaine-008 | 123-72-8 | Butanal |
| Tetracaine-009 | 109-65-9 | 1-Bromobutane |
| Tetracaine-010 | 94-24-6 | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
OptimisedRoute 2Steps 10 · Total yield /
Tetracaine-011555-06-6Tetracaine-0124740-24-3Tetracaine-01374-11-3Tetracaine-014586-76-5Tetracaine-015619-58-9Tetracaine-016109-73-9Tetracaine-01794-32-6Tetracaine-0182498-25-1Tetracaine-019107-07-3Tetracaine-020—Tetracaine-021124-40-3Tetracaine-009109-65-9Tetracaine-003108-01-0Tetracaine-00710012-47-2Tetracaine-01094-24-6API · Oxymetazoline Hydrochloride/Tetracaine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Tetracaine-011 | 555-06-6 | 4-Aminobenzoic acid sodium salt |
| Tetracaine-012 | 4740-24-3 | 4-(Butylamino)benzoic acid |
| Tetracaine-013 | 74-11-3Available | p-Chlorobenzoic acid |
| Tetracaine-014 | 586-76-5Available | 4-Bromobenzoic acid |
| Tetracaine-015 | 619-58-9Available | 4-Iodobenzoic acid |
| Tetracaine-016 | 109-73-9 | Butylamine |
| Tetracaine-017 | 94-32-6 | 4-(Butylamino)benzoic acid ethyl ester |
| Tetracaine-018 | 2498-25-1 | 2-(Dimethylamino)ethanol hydrochloride |
| Tetracaine-019 | 107-07-3 | 2-Chloroethanol |
| Tetracaine-020 | - | 4-(Butylamino)benzoic acid 2-chloroethyl ester |
| Tetracaine-021 | 124-40-3Available | N-Methylmethanamine |
| Tetracaine-009 | 109-65-9 | n-Butyl bromide |
| Tetracaine-003 | 108-01-0 | N,N-Dimethylaminoethanol |
| Tetracaine-007 | 10012-47-2 | 4-Aminobenzoic acid 2-(dimethylamino)ethyl ester |
| Tetracaine-010 | 94-24-6 | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
OptimisedRoute 3Steps 3 · Total yield 93.5g(Tetracaine)
Tetracaine-022150-13-0Tetracaine-008123-72-8Tetracaine-003108-01-0API · Oxymetazoline Hydrochloride/Tetracaine Hydrochloride
OptimisedRoute 4Steps 5 · Total yield /
Tetracaine-023586-75-4Tetracaine-02438152-18-0Tetracaine-02594-09-7Tetracaine-009109-65-9Tetracaine-003108-01-0Tetracaine-016109-73-9Tetracaine-01094-24-6Tetracaine-01794-32-6Tetracaine-022150-13-0API · Oxymetazoline Hydrochloride/Tetracaine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Tetracaine-023 | 586-75-4 | 4-Bromobenzoyl chloride |
| Tetracaine-024 | 38152-18-0 | 2-(Dimethylamino)ethyl 4-bromobenzoate |
| Tetracaine-025 | 94-09-7 | Ethyl 4-aminobenzoate |
| Tetracaine-009 | 109-65-9 | n-Butyl bromide |
| Tetracaine-003 | 108-01-0 | N,N-Dimethylaminoethanol |
| Tetracaine-016 | 109-73-9 | Monobutylamine |
| Tetracaine-010 | 94-24-6 | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
| Tetracaine-017 | 94-32-6 | 4-(Butylamino)benzoic acid ethyl ester |
| Tetracaine-022 | 150-13-0 | 4-Aminobenzoic acid |
OptimisedRoute 5Steps 3 · Total yield /
Tetracaine-02699-77-4Tetracaine-02594-09-7Tetracaine-008123-72-8Tetracaine-01794-32-6Tetracaine-003108-01-0Tetracaine-01094-24-6API · Oxymetazoline Hydrochloride/Tetracaine Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Tetracaine-026 | 99-77-4 | Ethyl 4-nitrobenzoate |
| Tetracaine-025 | 94-09-7 | 4-Aminobenzoic acid ethyl ester |
| Tetracaine-008 | 123-72-8 | Butyraldehyde |
| Tetracaine-017 | 94-32-6 | 4-(Butylamino)benzoic acid ethyl ester |
| Tetracaine-003 | 108-01-0 | N,N-Dimethyl-2-hydroxyethylamine |
| Tetracaine-010 | 94-24-6 | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
Frequently asked questions
What are the approved indications of Oxymetazoline Hydrochloride/Tetracaine Hydrochloride?
Approved indications include: Anaesthesia.
When does the Oxymetazoline Hydrochloride/Tetracaine Hydrochloride patent expire?
No public expiry year is available for Oxymetazoline Hydrochloride/Tetracaine Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Oxymetazoline Hydrochloride/Tetracaine Hydrochloride?
7 synthesis routes are recorded; the shortest is 3 steps with 93.5g(Tetracaine) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Oxymetazoline Hydrochloride/Tetracaine Hydrochloride intermediates?
6 intermediate CAS of Oxymetazoline Hydrochloride/Tetracaine Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Oxymetazoline Hydrochloride/Tetracaine Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29