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Bimatoprost/Timolol Maleate

Tier C — Watch / trade

Bimatoprost/Timolol Maleate

Allergan
Originator
2006
First approval
-
Expiry (public)
$0.58B ▲
Peak sales
Small molecule
Type

Targets:β-adrenoceptors, Prostanoid receptor

Brand:Ganfort

Indications (approved):Ocular hypertension, Open-angle glaucoma

Regional status

US
No progress
2001-08-01
EU
Approved
2006-05-19
China
Approved
2013-09-06
Japan
-

Factories producing this API9

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

9 producing factories on file — sign in to view the named list (factory details are not shown to guests).

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Synthetic routes & intermediates2 routes

Originator routes × 0Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 5 · Total yield 108.7g(Timolol Maleate (API))
Timolol Maleate-00130165-97-0Timolol Maleate-002106-89-8Timolol Maleate-00375-64-9Timolol Maleate-00429023-48-1Timolol Maleate-00526839-75-8Timolol Maleate-0065728-20-1Timolol Maleate-007110-91-8Timolol Maleate-00830165-96-9Timolol Maleate-00930315-47-0API · Bimatoprost/Timolol Maleate
CodeCAS No.Intermediate
Timolol Maleate-00130165-97-04-(4-Morpholinyl)-1,2,5-thiadiazol-3-ol
Timolol Maleate-002106-89-8(+/-)-2-(Chloromethyl)oxirane
Timolol Maleate-00375-64-9Available2-Methylpropan-2-amine
Timolol Maleate-00429023-48-11-(tert-Butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol
Timolol Maleate-00526839-75-8(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
Timolol Maleate-0065728-20-13,4-Dichloro-1,2,5-thiadiazole
Timolol Maleate-007110-91-8AvailableDiethylene oximide
Timolol Maleate-00830165-96-94-(4-chloro-1,2,5-thiadiazol-3-yl)morpholine
Timolol Maleate-00930315-47-0[(5S)-3-tert-Butyl-1,3-oxazolidin-5-yl]methanol
OptimisedRoute 2Steps 8 · Total yield /
Timolol Maleate-002106-89-8Timolol Maleate-01051594-55-9Timolol Maleate-01160827-45-4Timolol Maleate-00130165-97-0Timolol Maleate-012935528-00-0Timolol Maleate-01369500-53-4Timolol Maleate-014—Timolol Maleate-015295776-81-7Timolol Maleate-00375-64-9Timolol Maleate-00526839-75-8API · Bimatoprost/Timolol Maleate
CodeCAS No.Intermediate
Timolol Maleate-002106-89-82-(Chloromethyl)oxirane
Timolol Maleate-01051594-55-9(R)-(-)-2-(Chloromethyl)oxirane
Timolol Maleate-01160827-45-43-Chloropropane-1,2(S)-diol
Timolol Maleate-00130165-97-04-(4-Morpholinyl)-1,2,5-thiadiazol-3-ol
Timolol Maleate-012935528-00-0(2R)-1-Chloro-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol
Timolol Maleate-01369500-53-44-[4-[(2S)-Oxiran-2-ylmethoxy]-1,2,5-thiadiazol-3-yl]morpholine
Timolol Maleate-014-Sodium 4-(morpholin-4-yl)-1,2,5-thiadiazol-3-olate
Timolol Maleate-015295776-81-7(2S)-3-[[4-(Morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propane-1,2-diol
Timolol Maleate-00375-64-9Available2-Methylpropan-2-amine
Timolol Maleate-00526839-75-8(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol

Frequently asked questions

What are the approved indications of Bimatoprost/Timolol Maleate?

Approved indications include: Ocular hypertension, Open-angle glaucoma.

When does the Bimatoprost/Timolol Maleate patent expire?

No public expiry year is available for Bimatoprost/Timolol Maleate yet; this page updates once verified.

How many synthesis routes are recorded for Bimatoprost/Timolol Maleate?

2 synthesis routes are recorded; the shortest is 5 steps with 108.7g(Timolol Maleate (API)) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Bimatoprost/Timolol Maleate intermediates?

2 intermediate CAS of Bimatoprost/Timolol Maleate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Bimatoprost/Timolol Maleate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29