← Back to patent-cliff list
Atazanavir Sulfate
Tier B — Position earlyAtazanavir Sulfate
Bristol Myers Squibb
Originator
2003
First approval
-
Expiry (public)
$1.57B ▲
Peak sales
Small molecule
Type
Targets：HIV-1 protease
Brand：Reyataz
Indications (approved)：HIV infection
Regional status
US
Approved
2003-06-20
EU
Approved
2004-03-01
China
Approved
2005-05-13
Japan
Approved
2003-12-18
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 3Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 8 · Total yield /
ATAZ-0011122-91-4ATAZ-00224856-58-4ATAZ-003109-04-6ATAZ-004127406-56-8ATAZ-005870-46-2ATAZ-006198904-84-6ATAZ-007198904-85-7ATAZ-00898760-08-8ATAZ-009198904-86-8ATAZ-010198904-87-9ATAZ-011162537-11-3API · Atazanavir Sulfate
| Code | CAS No. | Intermediate |
|---|---|---|
| ATAZ-001 | 1122-91-4 | 4-bromobenzaldehyde |
| ATAZ-002 | 24856-58-4 | 1-bromo-4-(dimethoxymethyl)benzene |
| ATAZ-003 | 109-04-6 | 2-bromopyridine |
| ATAZ-004 | 127406-56-8 | 4-(pyridin-2-yl)benzaldehyde |
| ATAZ-005 | 870-46-2 | tert-butyl hydrazinecarboxylate |
| ATAZ-006 | 198904-84-6 | tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate |
| ATAZ-007 | 198904-85-7 | tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate |
| ATAZ-008 | 98760-08-8 | tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate |
| ATAZ-009 | 198904-86-8 | tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate |
| ATAZ-010 | 198904-87-9 | (2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol |
| ATAZ-011 | 162537-11-3 | (S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid |
OptimisedRoute 3Steps 3 · Total yield 39 g
ATAZ-004127406-56-8ATAZ-011162537-11-3ATAZ-016857904-00-8ATAZ-017857904-02-0ATAZ-0181006868-73-0ATAZ-0191006868-75-2ATAZ-020102123-74-0API · Atazanavir Sulfate
| Code | CAS No. | Intermediate |
|---|---|---|
| ATAZ-004 | 127406-56-8 | 4-(pyridin-2-yl)benzaldehyde |
| ATAZ-011 | 162537-11-3 | (S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid |
| ATAZ-016 | 857904-00-8 | methyl (S)-(1-hydrazinyl-3,3-dimethyl-1-oxobutan-2-yl)carbamate hydrochloride |
| ATAZ-017 | 857904-02-0 | methyl (S)-(3-methyl-1-oxo-1-(2-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-yl)carbamate |
| ATAZ-018 | 1006868-73-0 | methyl ((S)-1-(((S)-4-chloro-3-oxo-1-phenylbutan-2-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate |
| ATAZ-019 | 1006868-75-2 | methyl ((5S,11S,14S)-11-benzyl-5-(tert-butyl)-15,15-dimethyl-3,6,10,13-tetraoxo-8-(4-(pyridin-2-yl)benzyl)-2-oxa-4,7,8,12-tetraazahexadecan-14-yl)carbamate |
| ATAZ-020 | 102123-74-0 | tert-butyl (S)-(4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate |
OptimisedRoute 4Steps 8 · Total yield /
ATAZ-005870-46-2ATAZ-009198904-86-8ATAZ-0211129-35-7ATAZ-02298061-21-3ATAZ-0234385-62-0ATAZ-024198905-07-6ATAZ-02572155-45-4ATAZ-026198905-08-7ATAZ-027198905-09-8ATAZ-0281966903-22-9ATAZ-029198905-10-1API · Atazanavir Sulfate
| Code | CAS No. | Intermediate |
|---|---|---|
| ATAZ-005 | 870-46-2 | tert-butyl hydrazinecarboxylate |
| ATAZ-009 | 198904-86-8 | tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate |
| ATAZ-021 | 1129-35-7 | methyl 4-cyanobenzoate |
| ATAZ-022 | 98061-21-3 | methyl 4-(pyridin-2-yl)benzoate |
| ATAZ-023 | 4385-62-0 | 4-(pyridin-2-yl)benzoic acid |
| ATAZ-024 | 198905-07-6 | (isobutyl carbonic) 4-(pyridin-2-yl)benzoic anhydride |
| ATAZ-025 | 72155-45-4 | (S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate |
| ATAZ-026 | 198905-08-7 | (1R,2S)-2-((tert-butoxycarbonyl)amino)-1-cyano-3-phenylpropyl 4-(pyridin-2-yl)benzoate |
| ATAZ-027 | 198905-09-8 | tert-butyl (E)-2-((2R,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butylidene)hydrazine-1-carboxylate |
| ATAZ-028 | 1966903-22-9 | tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butyl)hydrazine-1-carboxylate |
| ATAZ-029 | 198905-10-1 | tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzoyl)hydrazine-1-carboxylate |
OptimisedRoute 5Steps 6 · Total yield 5.1 g
ATAZ-00898760-08-8ATAZ-011162537-11-3ATAZ-030920757-34-2ATAZ-03162965-10-0ATAZ-0321028634-77-6ATAZ-033—ATAZ-0341028634-78-7ATAZ-0351028634-75-4ATAZ-0361028634-76-5API · Atazanavir Sulfate
| Code | CAS No. | Intermediate |
|---|---|---|
| ATAZ-008 | 98760-08-8 | tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate |
| ATAZ-011 | 162537-11-3 | (S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid |
| ATAZ-030 | 920757-34-2 | 2-(4-(hydrazinylmethyl)phenyl)pyridine |
| ATAZ-031 | 62965-10-0 | (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid |
| ATAZ-032 | 1028634-77-6 | benzyl (S)-(3,3-dimethyl-1-oxo-1-(2-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-yl)carbamate |
| ATAZ-033 | - | benzyl ((S)-1-(2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate |
| ATAZ-034 | 1028634-78-7 | benzyl ((S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate hydrochloride |
| ATAZ-035 | 1028634-75-4 | methyl ((5S,10S,11S,14S)-11-benzyl-5-(tert-butyl)-10-hydroxy-15,15-dimethyl-3,6,13-trioxo-1-phenyl-8-(4-(pyridin-2-yl)benzyl)-2-oxa-4,7,8,12-tetraazahexadecan-14-yl)carbamate |
| ATAZ-036 | 1028634-76-5 | methyl ((S)-1-(((2S,3S)-4-(2-((S)-2-amino-3,3-dimethylbutanoyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate |
ProcessRoute 2Steps 7 · Total yield 3.49 kg
ATAZ-003109-04-6ATAZ-004127406-56-8ATAZ-005870-46-2ATAZ-006198904-84-6ATAZ-007198904-85-7ATAZ-00898760-08-8ATAZ-009198904-86-8ATAZ-010198904-87-9ATAZ-011162537-11-3ATAZ-01287199-17-5ATAZ-01399113-35-6ATAZ-014425622-87-3ATAZ-015170502-84-8API · Atazanavir Sulfate
| Code | CAS No. | Intermediate |
|---|---|---|
| ATAZ-003 | 109-04-6 | 2-bromopyridine |
| ATAZ-004 | 127406-56-8 | 4-(pyridin-2-yl)benzaldehyde |
| ATAZ-005 | 870-46-2 | tert-butyl hydrazinecarboxylate |
| ATAZ-006 | 198904-84-6 | tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate |
| ATAZ-007 | 198904-85-7 | tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate |
| ATAZ-008 | 98760-08-8 | tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate |
| ATAZ-009 | 198904-86-8 | tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate |
| ATAZ-010 | 198904-87-9 | (2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol |
| ATAZ-011 | 162537-11-3 | (S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid |
| ATAZ-012 | 87199-17-5 | (4-formylphenyl)boronic acid |
| ATAZ-013 | 99113-35-6 | tert-butyl ((2S,3R)-3,4-dihydroxy-1-phenylbutan-2-yl)carbamate |
| ATAZ-014 | 425622-87-3 | (6R,7S)-7-benzyl-2,2,3,3,11,11-hexamethyl-9-oxo-4,10-dioxa-8-aza-3-siladodecan-6-yl methanesulfonate |
| ATAZ-015 | 170502-84-8 | (2R,3S)-3-((tert-butoxycarbonyl)amino)-1-hydroxy-4-phenylbutan-2-yl methanesulfonate |
Frequently asked questions
What are the approved indications of Atazanavir Sulfate?
Approved indications include: HIV infection.
When does the Atazanavir Sulfate patent expire?
No public expiry year is available for Atazanavir Sulfate yet; this page updates once verified.
How many synthesis routes are recorded for Atazanavir Sulfate?
5 synthesis routes are recorded; the shortest is 3 steps with 39 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Atazanavir Sulfate intermediates?
All intermediates in Atazanavir Sulfate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Atazanavir Sulfate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29