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Tirofiban Hydrochloride Hydrate

Tier C — Watch / trade

Tirofiban Hydrochloride Hydrate

MSD (Merck Sharp & Dohme)
Originator
1998
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets:GP IIb/IIIa

Brand:Aggrastat

Indications (approved):Unstable angina, Myocardial infarction, Coronary thrombosis, Acute coronary syndrome, Thrombosis

Regional status

US
Approved
1998-05-14
EU
-
China
Approved
2003-06-13
Japan
-

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates2 routes

Originator routes × 1Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 11 · Total yield 0.29 g
TIRO-001622-26-4TIRO-00289151-44-0TIRO-0032605-67-6TIRO-004142355-80-4TIRO-005142355-82-6TIRO-006142247-38-9TIRO-007142355-83-7TIRO-008142355-81-5TIRO-0091164-16-5TIRO-010142355-84-8TIRO-011142373-56-6TIRO-012142373-57-7TIRO-0132386-60-9TIRO-014142373-58-8API · Tirofiban Hydrochloride Hydrate
CodeCAS No.Intermediate
TIRO-001622-26-42-(piperidin-4-yl)ethan-1-ol
TIRO-00289151-44-0tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate
TIRO-0032605-67-6methyl 2-(triphenylphosphoranylidene)acetate
TIRO-004142355-80-4(E)-tert-butyl 4-(4-methoxy-4-oxobut-2-en-1-yl)piperidine-1-carboxylate
TIRO-005142355-82-6tert-butyl 4-(4-methoxy-4-oxobutyl)piperidine-1-carboxylate
TIRO-006142247-38-94-(1-(tert-butoxycarbonyl)piperidin-4-yl)butanoic acid
TIRO-007142355-83-7tert-butyl 4-(4-hydroxybutyl)piperidine-1-carboxylate
TIRO-008142355-81-5tert-butyl 4-(4-bromobutyl)piperidine-1-carboxylate
TIRO-0091164-16-5(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoic acid
TIRO-010142355-84-8(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(4-(1-(tert-butoxycarbonyl)piperidin-4-yl)butoxy)phenyl)propanoic acid
TIRO-011142373-56-6(S)-tert-butyl 4-(4-(4-(2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)butyl)piperidine-1-carboxylate
TIRO-012142373-57-7(S)-tert-butyl 4-(4-(4-(2-amino-3-methoxy-3-oxopropyl)phenoxy)butyl)piperidine-1-carboxylate
TIRO-0132386-60-9butane-1-sulfonyl chloride
TIRO-014142373-58-8(S)-tert-butyl 4-(4-(4-(2-(butylsulfonamido)-3-methoxy-3-oxopropyl)phenoxy)butyl)piperidine-1-carboxylate
OptimisedRoute 2Steps 5 · Total yield 348.00 g
TIRO-01560-18-4TIRO-016—TIRO-017149490-60-8TIRO-018149463-65-0TIRO-019149490-61-9TIRO-020144494-65-5TIRO-021108-89-4TIRO-022109-70-6API · Tirofiban Hydrochloride Hydrate
CodeCAS No.Intermediate
TIRO-01560-18-4(S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
TIRO-016-butane-1-sulfonyl chloride hydrochloride
TIRO-017149490-60-8Available(S)-2-(butylsulfonamido)-3-(4-hydroxyphenyl)propanoic acid
TIRO-018149463-65-0Available-
TIRO-019149490-61-9(S)-2-(butylsulfonamido)-3-(4-(4-(pyridin-4-yl)butoxy)phenyl)propanoic acid
TIRO-020144494-65-5(S)-2-(butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid
TIRO-021108-89-4Available4-methylpyridine
TIRO-022109-70-61-bromo-3-chloropropane

Frequently asked questions

What are the approved indications of Tirofiban Hydrochloride Hydrate?

Approved indications include: Unstable angina, Myocardial infarction, Coronary thrombosis, Acute coronary syndrome, Thrombosis.

When does the Tirofiban Hydrochloride Hydrate patent expire?

No public expiry year is available for Tirofiban Hydrochloride Hydrate yet; this page updates once verified.

How many synthesis routes are recorded for Tirofiban Hydrochloride Hydrate?

2 synthesis routes are recorded; the shortest is 5 steps with 348.00 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Tirofiban Hydrochloride Hydrate intermediates?

3 intermediate CAS of Tirofiban Hydrochloride Hydrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Tirofiban Hydrochloride Hydrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29