Sevelamer Carbonate

Tier B — Position early

Sevelamer Carbonate

Genzyme Corporation

Originator

2000

First approval

Expiry (public)

$1.04B ▲

Peak sales

Small molecule

Type

Targets：Phosphates

Brand：Renvela, Renvela/Renagel

Indications (approved)：Hyperphosphataemia

Regional status

Withdrawn

Approved

2000-01-28

China

Approved

2013-06-03

Japan

Synthetic routes & intermediates4 routes

Originator routes × 0Optimised (non-patent) × 3Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 3 · Total yield /

SEVE-001—SEVE-002—SEVE-003106-89-8SEVE-004—API · Sevelamer Carbonate

Code	CAS No.	Intermediate
SEVE-001	-	2-methylbutan-1-amine hydrochloride(1:x)
SEVE-002	-	2-methylbutan-1-amine hydrochloride(1:x)
SEVE-003	106-89-8	2-(chloromethyl)oxirane
SEVE-004	-	5-((3-((4-(aminomethyl)-2-methylhexyl)amino)-2-hydroxypropyl)amino)-2-ethyl-4-methylpentan-1-aminium chloride

OptimisedRoute 2Steps 3 · Total yield 452 g

SEVE-003106-89-8SEVE-004—SEVE-005107-11-9SEVE-006—SEVE-007—API · Sevelamer Carbonate

Code	CAS No.	Intermediate
SEVE-003	106-89-8	2-(chloromethyl)oxirane
SEVE-004	-	5-((3-((4-(aminomethyl)-2-methylhexyl)amino)-2-hydroxypropyl)amino)-2-ethyl-4-methylpentan-1-aminium chloride
SEVE-005	107-11-9 Available	prop-2-en-1-amine
SEVE-006	-	(E)-2,2'-(diazene-1,2-diyl)bis(2-methylpropanamide) dihydrochloride
SEVE-007	-	5-((3-((4-(aminomethyl)-2-methylhexyl)amino)-2-hydroxypropyl)amino)-2-ethyl-4-methylpentan-1-aminium

OptimisedRoute 4Steps 3 · Total yield 250 g

SEVE-001—SEVE-004—SEVE-00810017-11-5SEVE-00996-23-1API · Sevelamer Carbonate

Code	CAS No.	Intermediate
SEVE-001	-	2-methylbutan-1-amine hydrochloride(1:x)
SEVE-004	-	5-((3-((4-(aminomethyl)-2-methylhexyl)amino)-2-hydroxypropyl)amino)-2-ethyl-4-methylpentan-1-aminium chloride
SEVE-008	10017-11-5	prop-2-en-1-amine hydrochloride
SEVE-009	96-23-1	1,3-dichloropropan-2-ol

ProcessRoute 3Steps 2 · Total yield 52.7 kg

SEVE-001—SEVE-003106-89-8SEVE-004—API · Sevelamer Carbonate

Code	CAS No.	Intermediate
SEVE-001	-	2-methylbutan-1-amine hydrochloride(1:x)
SEVE-003	106-89-8	2-(chloromethyl)oxirane
SEVE-004	-	5-((3-((4-(aminomethyl)-2-methylhexyl)amino)-2-hydroxypropyl)amino)-2-ethyl-4-methylpentan-1-aminium chloride

Frequently asked questions

What are the approved indications of Sevelamer Carbonate?

Approved indications include: Hyperphosphataemia.

When does the Sevelamer Carbonate patent expire?

No public expiry year is available for Sevelamer Carbonate yet; this page updates once verified.

How many synthesis routes are recorded for Sevelamer Carbonate?

4 synthesis routes are recorded; the shortest is 2 steps with 52.7 kg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Sevelamer Carbonate intermediates?

1 intermediate CAS of Sevelamer Carbonate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Sevelamer Carbonate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29