Trofinetide

Tier C — Watch / trade

Trofinetide

Walter Reed Army Institute

Originator

2023

First approval

Expiry (public)

$0.18B ▲

Peak sales

Small molecule

Type

Targets：Neuropeptide receptor, Cytokines

Brand：Daybue

Indications (approved)：Rett syndrome

Regional status

Approved

2023-03-10

Approved

2026-08-20

China

Japan

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 5 · Total yield 0.27 g

TROFIN-00142856-71-3TROFIN-002220060-08-2TROFIN-0031138-80-3TROFIN-004847952-40-3TROFIN-005869001-86-5TROFIN-006—TROFIN-007869001-94-5Trofinetide—API · Trofinetide

Code	CAS No.	Intermediate
TROFIN-001	42856-71-3 Available	(S)-2-methylpyrrolidine-2-carboxylic acid
TROFIN-002	220060-08-2 Available	methyl (S)-2-methylpyrrolidine-2-carboxylate hydrochloride
TROFIN-003	1138-80-3 Available	2-(((benzyloxy)carbonyl)amino)acetic acid
TROFIN-004	847952-40-3 Available	methyl (S)-1-(((benzyloxy)carbonyl)glycyl)-2-methylpyrrolidine-2-carboxylate
TROFIN-005	869001-86-5 Available	(S)-1-(((benzyloxy)carbonyl)glycyl)-2-methylpyrrolidine-2-carboxylic acid
TROFIN-006	-	dibenzyl L-glutamate 4-methylbenzenesulfonate
TROFIN-007	869001-94-5 Available	dibenzyl ((S)-1-(((benzyloxy)carbonyl)glycyl)-2-methylpyrrolidine-2-carbonyl)-L-glutamate
Trofinetide	-	-

Frequently asked questions

What are the approved indications of Trofinetide?

Approved indications include: Rett syndrome.

When does the Trofinetide patent expire?

No public expiry year is available for Trofinetide yet; this page updates once verified.

How many synthesis routes are recorded for Trofinetide?

1 synthesis routes are recorded; the shortest is 5 steps with 0.27 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Trofinetide intermediates?

6 intermediate CAS of Trofinetide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Trofinetide intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29