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Cevimeline Hydrochloride Hydrate

Tier C — Watch / trade

Cevimeline Hydrochloride Hydrate

Daiichi Sankyo Co., Ltd.
Originator
2000
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets:CHRM1, CHRM3

Brand:Evoxac, Saligren

Indications (approved):Sjögren's syndrome

Regional status

US
Approved
2000-01-11
EU
-
China
Discontinued
2011-08-02
Japan
Approved
2001-06-20

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 3 · Total yield 1.90 g
CEVI-0013731-38-2CEVI-00241353-91-7CEVI-003107220-26-8API · Cevimeline Hydrochloride Hydrate
CodeCAS No.Intermediate
CEVI-0013731-38-2quinuclidin-3-one
CEVI-00241353-91-74-azaspiro[bicyclo[2.2.2]octane-2,2'-oxirane]
CEVI-003107220-26-83-(mercaptomethyl)quinuclidin-3-ol
OptimisedRoute 2Steps 3 · Total yield 1.80 g
CEVI-00241353-91-7CEVI-004173075-53-1CEVI-0051067881-02-0CEVI-006105-57-7API · Cevimeline Hydrochloride Hydrate
CodeCAS No.Intermediate
CEVI-00241353-91-74-azaspiro[bicyclo[2.2.2]octane-2,2'-oxirane]
CEVI-004173075-53-1quinuclidin-3-one hydrochloride
CEVI-0051067881-02-0S-((3-hydroxyquinuclidin-3-yl)methyl) ethanethioate ethanethioate
CEVI-006105-57-71,1-diethoxyethane
OptimisedRoute 3Steps 3 · Total yield 1.80 g
CEVI-00241353-91-7CEVI-004173075-53-1CEVI-006105-57-7CEVI-0071435450-13-7API · Cevimeline Hydrochloride Hydrate
CodeCAS No.Intermediate
CEVI-00241353-91-74-azaspiro[bicyclo[2.2.2]octane-2,2'-oxirane]
CEVI-004173075-53-1quinuclidin-3-one hydrochloride
CEVI-006105-57-71,1-diethoxyethane
CEVI-0071435450-13-73-(bromomethyl)quinuclidin-3-ol hydrobromide
OptimisedRoute 4Steps 5 · Total yield 6.70 g
CEVI-00241353-91-7CEVI-004173075-53-1CEVI-00878872-75-0CEVI-0091467663-46-2CEVI-0101467663-56-4CEVI-011507-09-5CEVI-012109-92-2API · Cevimeline Hydrochloride Hydrate
CodeCAS No.Intermediate
CEVI-00241353-91-74-azaspiro[bicyclo[2.2.2]octane-2,2'-oxirane]
CEVI-004173075-53-1quinuclidin-3-one hydrochloride
CEVI-00878872-75-0S-(1-ethoxyethyl) ethanethioate
CEVI-0091467663-46-23-(((1-ethoxyethyl)thio)methyl)quinuclidin-3-ol
CEVI-0101467663-56-43-(((1-ethoxyethyl)thio)methyl)quinuclidin-3-ol benzoate
CEVI-011507-09-5ethanethioic S-acid
CEVI-012109-92-2ethoxyethene

Frequently asked questions

What are the approved indications of Cevimeline Hydrochloride Hydrate?

Approved indications include: Sjögren's syndrome.

When does the Cevimeline Hydrochloride Hydrate patent expire?

No public expiry year is available for Cevimeline Hydrochloride Hydrate yet; this page updates once verified.

How many synthesis routes are recorded for Cevimeline Hydrochloride Hydrate?

4 synthesis routes are recorded; the shortest is 3 steps with 1.90 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Cevimeline Hydrochloride Hydrate intermediates?

All intermediates in Cevimeline Hydrochloride Hydrate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Cevimeline Hydrochloride Hydrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29