Zuranolone
Tier C — Watch / tradeZuranolone
Targets：GABAAR
Brand：Zurzuvae
Indications (approved)：产后抑郁症, Depressive disorder
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| SAGE-217-001 | 734-32-7Available | (8R,9S,10R,13S,14S)-13-methyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| SAGE-217-002 | 5696-51-5Available | (5R,8R,9R,10S,13S,14S)-13-methyltetradecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione |
| SAGE-217-003 | 1632051-92-3Available | (3R,5R,8R,9R,10S,13S,14S)-3-hydroxy-3,13-dimethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-one |
| SAGE-217-004 | 1430063-91-4Available | (3R,5R,8R,9R,10S,13S,14S,Z)-17-ethylidene-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| SAGE-217-005 | 1430063-92-5Available | (3R,5R,8R,9R,10S,13S,14S,17S)-17-(1-hydroxyethyl)-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| SAGE-217-006 | 162882-77-1Available | 1-((3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one |
| SAGE-217-007 | 1430063-93-6Available | 2-bromo-1-((3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one |
| SAGE-217-008 | 31108-57-3Available | 1H-pyrazole-4-carbonitrile |
Frequently asked questions
What are the approved indications of Zuranolone?
Approved indications include: 产后抑郁症, Depressive disorder.
When does the Zuranolone patent expire?
No public expiry year is available for Zuranolone yet; this page updates once verified.
How many synthesis routes are recorded for Zuranolone?
1 synthesis routes are recorded; the shortest is 7 steps with 9 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Zuranolone intermediates?
8 intermediate CAS of Zuranolone are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Zuranolone intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29