Ensifentrine

Tier C — Watch / trade

Ensifentrine

Vernalis Plc

Originator

2024

First approval

Expiry (public)

$0.18B ▲

Peak sales

Small molecule

Type

Targets：PDE3, PDE4

Brand：Ohtuvayre

Indications (approved)：Chronic obstructive pulmonary disease

Regional status

Approved

2024-06-26

Phase III

2020-09-22

China

Phase III

2023-03-10

Japan

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 5 · Total yield 11.9 g

RPL-554-00175535-95-4RPL-554-00275535-96-5RPL-554-00388-05-1RPL-554-00476536-66-8RPL-554-005574-98-1RPL-554-006298680-38-3RPL-554-007298680-39-4API · Ensifentrine

Code	CAS No.	Intermediate
RPL-554-001	75535-95-4 Available	1-(3,4-dimethoxyphenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione
RPL-554-002	75535-96-5 Available	2-chloro-9,10-dimethoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one
RPL-554-003	88-05-1 Available	2,4,6-trimethylaniline
RPL-554-004	76536-66-8 Available	(E)-2-(mesitylimino)-9,10-dimethoxy-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
RPL-554-005	574-98-1 Available	2-(2-bromoethyl)isoindoline-1,3-dione
RPL-554-006	298680-38-3 Available	(E)-2-(2-(2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)isoindoline-1,3-dione
RPL-554-007	298680-39-4 Available	(E)-3-(2-aminoethyl)-2-(mesitylimino)-9,10-dimethoxy-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one

Frequently asked questions

What are the approved indications of Ensifentrine?

Approved indications include: Chronic obstructive pulmonary disease.

When does the Ensifentrine patent expire?

No public expiry year is available for Ensifentrine yet; this page updates once verified.

How many synthesis routes are recorded for Ensifentrine?

1 synthesis routes are recorded; the shortest is 5 steps with 11.9 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ensifentrine intermediates?

7 intermediate CAS of Ensifentrine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ensifentrine intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29