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Ritonavir

Tier C — Watch / trade

Ritonavir

AbbVie
Originator
1996
First approval
-
Expiry (public)
$0.42B ▲
Peak sales
Small molecule
Type

Targets：HIV-1 protease

Brand：Norvir

Indications (approved)：HIV infection

Regional status

US
Withdrawn
EU
Approved
1996-08-25
China
Approved
2002-08-29
Japan
Approved
1998-09-25

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 9 · Total yield 100.00 mg
RITO-0016372-14-1RITO-00259830-60-3RITO-003137649-69-5RITO-00440635-67-4RITO-005—RITO-006177469-39-5RITO-007144141-68-4RITO-008144163-44-0RITO-00998-80-6RITO-010165315-39-9RITO-011144163-97-3RITO-012144164-11-4RITO-013154212-61-0RITO-014105-39-5RITO-01533142-21-1RITO-016115-08-2RITO-01732955-22-9RITO-01838585-74-9RITO-0197693-46-1RITO-020563-83-7RITO-02113515-65-6RITO-022534-07-6RITO-0236306-52-1RITO-024154212-60-9RITO-025162537-10-2RITO-026154248-99-4API · Ritonavir
CodeCAS No.Intermediate
RITO-0016372-14-1(S)-benzyl (1-hydroxy-3-phenylpropan-2-yl)carbamate
RITO-00259830-60-3(S)-benzyl (1-oxo-3-phenylpropan-2-yl)carbamate
RITO-003137649-69-5dibenzyl ((2S,3R,4R,5S)-3,4-dihydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate
RITO-00440635-67-41-bromo-2-methyl-1-oxopropan-2-yl acetate
RITO-005-(5S,6R,7R,8S)-5,8-dibenzyl-7-bromo-3,10-dioxo-1,12-diphenyl-2,11-dioxa-4,9-diazadodecan-6-yl acetate
RITO-006177469-39-5dibenzyl ((1S,1'S)-((2R,3R)-oxirane-2,3-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate
RITO-007144141-68-4dibenzyl ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate
RITO-008144163-44-0(2S,3S,5S)-2,5-diamino-1,6-diphenylhexan-3-ol
RITO-00998-80-6phenylboronic acid
RITO-010165315-39-9(S)-1-((4S,6S)-4-benzyl-2-phenyl-1,3,2-oxazaborinan-6-yl)-2-phenylethanamine
RITO-011144163-97-34-nitrophenyl (thiazol-5-ylmethyl) carbonate
RITO-012144164-11-4thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate
RITO-013154212-61-0(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid
RITO-014105-39-5ethyl 2-chloroacetate
RITO-01533142-21-1ethyl 2-chloro-3-oxopropanoate
RITO-016115-08-2methanethioamide
RITO-01732955-22-9ethyl thiazole-5-carboxylate
RITO-01838585-74-9thiazol-5-ylmethanol
RITO-0197693-46-14-nitrophenyl carbonochloridate
RITO-020563-83-7isobutyramide
RITO-02113515-65-62-methylpropanethioamide
RITO-022534-07-61,3-dichloropropan-2-one
RITO-0236306-52-1methyl L-valinate hydrochloride
RITO-024154212-60-91-(2-isopropylthiazol-4-yl)-N-methylmethanamine
RITO-025162537-10-2-
RITO-026154248-99-4(S)-methyl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate
OptimisedRoute 2Steps 7 · Total yield 2.60 g
RITO-011144163-97-3RITO-012144164-11-4RITO-013154212-61-0RITO-02763-91-2RITO-028111138-83-1RITO-0296921-34-2RITO-030156732-13-7RITO-031156732-15-9RITO-032162849-93-6RITO-033169870-02-4API · Ritonavir
CodeCAS No.Intermediate
RITO-011144163-97-34-nitrophenyl (thiazol-5-ylmethyl) carbonate
RITO-012144164-11-4thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate
RITO-013154212-61-0(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid
RITO-02763-91-2L-phenylalanine
RITO-028111138-83-1(S)-benzyl 2-(dibenzylamino)-3-phenylpropanoate
RITO-0296921-34-2benzylmagnesium chloride
RITO-030156732-13-7(S,E)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one
RITO-031156732-15-9(2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol
RITO-032162849-93-6tert-butyl ((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
RITO-033169870-02-4tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate
OptimisedRoute 3Steps 8 · Total yield /
RITO-02763-91-2RITO-033169870-02-4RITO-0343182-95-4RITO-035749167-08-6RITO-036403735-04-6RITO-037172695-25-9RITO-03872155-45-4RITO-0396125-24-2RITO-0401360824-68-5RITO-041144163-85-9API · Ritonavir
CodeCAS No.Intermediate
RITO-02763-91-2L-phenylalanine
RITO-033169870-02-4tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate
RITO-0343182-95-4(S)-2-amino-3-phenylpropan-1-ol
RITO-035749167-08-6(S)-1-chloro-3-phenylpropan-2-amine
RITO-036403735-04-6(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate
RITO-037172695-25-9(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate
RITO-03872155-45-4(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate
RITO-0396125-24-2(2-nitroethyl)benzene
RITO-0401360824-68-5tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate
RITO-041144163-85-9tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate

Frequently asked questions

What are the approved indications of Ritonavir?

Approved indications include: HIV infection.

When does the Ritonavir patent expire?

No public expiry year is available for Ritonavir yet; this page updates once verified.

How many synthesis routes are recorded for Ritonavir?

3 synthesis routes are recorded; the shortest is 7 steps with 2.60 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ritonavir intermediates?

All intermediates in Ritonavir routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Ritonavir intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29