Omaveloxolone
Tier C — Watch / tradeOmaveloxolone
Targets：Nrf2
Brand：SKYCLARYS
Indications (approved)：Friedreich's ataxia
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| OMAV-001 | 218600-44-3 | (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxylic acid |
| OMAV-002 | 1192122-92-1 | (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carbonyl azide |
| OMAV-003 | 1192122-95-4 | (4aR,6aS,6bR,8aS,12aS,12bR,14bS)-8a-isocyanato-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-2-carbonitrile |
| OMAV-004 | 1192123-13-9 | (4aR,6aS,6bR,8aS,12aS,12bR,14bS)-8a-amino-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-2-carbonitrile |
Frequently asked questions
What are the approved indications of Omaveloxolone?
Approved indications include: Friedreich's ataxia.
When does the Omaveloxolone patent expire?
No public expiry year is available for Omaveloxolone yet; this page updates once verified.
How many synthesis routes are recorded for Omaveloxolone?
1 synthesis routes are recorded; the shortest is 4 steps with 16.35 g (Omaveloxolone) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Omaveloxolone intermediates?
All intermediates in Omaveloxolone routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Omaveloxolone intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29