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Bromfenac Sodium
Tier C — Watch / tradeBromfenac Sodium
-
Originator
1997
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：COXs
Brand：BromSite, Yellox, Remura, XiDay (former Brand Name), Prolensa, Bromday, Bronuck, Duract, Xibrom QD, Xibrom
Indications (approved)：Inflammatory disease, Postoperative pain, 眼睛发炎, 眼睛疼痛
Regional status
US
Approved
2005-03-24
EU
Approved
2011-05-18
China
Approved
2009-01-01
Japan
Approved
2000-03-10
Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
1 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates9 routes
Originator routes × 0Optimised (non-patent) × 5Process routes × 4
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 4Steps 4 · Total yield 257.8g(Bromfenac Sodium (API))
Bromfenac Sodium-0031140-17-6Bromfenac Sodium-01992433-07-3Bromfenac Sodium-020598-21-0Bromfenac Sodium-02179-04-9Bromfenac Sodium-02213094-51-4Bromfenac Sodium-023541-88-8Bromfenac Sodium-0242126789-07-7Bromfenac Sodium-0252126789-08-8Bromfenac Sodium-0262126789-09-9API · Bromfenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Bromfenac Sodium-003 | 1140-17-6 | 2-Amino-4'-bromobenzophenone |
| Bromfenac Sodium-019 | 92433-07-3 | N-[2-(4-Bromobenzoyl)phenyl]acetamide |
| Bromfenac Sodium-020 | 598-21-0 | 2-Bromoacetyl bromide |
| Bromfenac Sodium-021 | 79-04-9Available | 2-Chloroacetyl chloride |
| Bromfenac Sodium-022 | 13094-51-4Available | Bromoacetic anhydride |
| Bromfenac Sodium-023 | 541-88-8Available | Chloroacetic anhydride |
| Bromfenac Sodium-024 | 2126789-07-7 | N-Acetyl-2-bromo-N-[2-(4-bromobenzoyl)phenyl]acetamide |
| Bromfenac Sodium-025 | 2126789-08-8 | N-Acetyl-N-[2-(4-bromobenzoyl)phenyl]-2-chloroacetamide |
| Bromfenac Sodium-026 | 2126789-09-9 | 1-Acetyl-7-(4-bromobenzoyl)-1,3-dihydro-2H-indol-2-one |
OptimisedRoute 5Steps 4 · Total yield 83.27g(Bromfenac Sodium (API))
Bromfenac Sodium-027612-22-6Bromfenac Sodium-028578-54-1Bromfenac Sodium-029586-75-4Bromfenac Sodium-0302362015-36-7Bromfenac Sodium-0314637-24-5Bromfenac Sodium-032—API · Bromfenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Bromfenac Sodium-027 | 612-22-6 | 1-Ethyl-2-nitrobenzene |
| Bromfenac Sodium-028 | 578-54-1Available | 2-Ethylaniline |
| Bromfenac Sodium-029 | 586-75-4 | 4-Bromobenzoyl chloride |
| Bromfenac Sodium-030 | 2362015-36-7 | (2-Amino-3-ethylphenyl)(4-bromophenyl)methanone |
| Bromfenac Sodium-031 | 4637-24-5Available | N,N-Dimethylformamide dimethyl acetal |
| Bromfenac Sodium-032 | - | [2-Amino-3-[3-(dimethylamino)prop-2-en-1-yl]phenyl](4-bromophenyl)methanone |
OptimisedRoute 6Steps 4 · Total yield 16.9g(Bromfenac Sodium (API))
Bromfenac Sodium-033619-42-1Bromfenac Sodium-0345798-75-4Bromfenac Sodium-03540649-38-5Bromfenac Sodium-036412321-62-1Bromfenac Sodium-0372413011-17-1Bromfenac Sodium-0382413011-19-3Bromfenac Sodium-0392413011-18-2Bromfenac Sodium-04091714-94-2,91714-93-1API · Bromfenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Bromfenac Sodium-033 | 619-42-1 | Methyl 4-bromobenzoate |
| Bromfenac Sodium-034 | 5798-75-4Available | 4-Bromobenzoic acid ethyl ester |
| Bromfenac Sodium-035 | 40649-38-5 | Methyl 3-(2-methoxy-2-oxoethyl)-2-oxocyclohexane-1-carboxylate |
| Bromfenac Sodium-036 | 412321-62-1 | Ethyl 3-(2-ethoxy-2-oxoethyl)-2-oxocyclohexane-1-carboxylate |
| Bromfenac Sodium-037 | 2413011-17-1 | [3-(4-Bromobenzoyl)-2-oxocyclohexyl]acetic acid |
| Bromfenac Sodium-038 | 2413011-19-3 | [1,3-Dibromo-3-(4-bromobenzoyl)-2-oxocyclohexyl]acetic acid |
| Bromfenac Sodium-039 | 2413011-18-2 | [3-(4-Bromobenzoyl)-1,3-dichloro-2-oxocyclohexyl]acetic acid |
| Bromfenac Sodium-040 | 91714-94-2,91714-93-1 | [2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid |
OptimisedRoute 7Steps 2 · Total yield 34.3g(Bromfenac Sodium (API))
Bromfenac Sodium-04116532-79-9Bromfenac Sodium-0423740-52-1Bromfenac Sodium-043114623-14-2API · Bromfenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Bromfenac Sodium-041 | 16532-79-9 | 2-(4-Bromophenyl)acetonitrile |
| Bromfenac Sodium-042 | 3740-52-1 | 2-(2-Nitrophenyl)acetic acid |
| Bromfenac Sodium-043 | 114623-14-2 | [3-(4-Bromophenyl)-2,1-benzoxazol-7-yl]acetic acid |
OptimisedRoute 8Steps 5 · Total yield 27.9g(Bromfenac Sodium (API))
Bromfenac Sodium-0443342-78-7Bromfenac Sodium-045103205-34-1Bromfenac Sodium-0462755909-84-1Bromfenac Sodium-029586-75-4Bromfenac Sodium-0472755909-85-2Bromfenac Sodium-00791714-94-2,91714-93-1API · Bromfenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Bromfenac Sodium-044 | 3342-78-7 | (2-Aminophenyl)acetic acid |
| Bromfenac Sodium-045 | 103205-34-1 | (2-Acetamidophenyl)acetic acid |
| Bromfenac Sodium-046 | 2755909-84-1 | (2-Acetamido-5-sulfophenyl)acetic acid |
| Bromfenac Sodium-029 | 586-75-4 | 4-Bromobenzoyl chloride |
| Bromfenac Sodium-047 | 2755909-85-2 | [2-Acetamido-3-(4-bromobenzoyl)-5-sulfophenyl]acetic acid |
| Bromfenac Sodium-007 | 91714-94-2,91714-93-1 | [2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid |
ProcessRoute 1Steps 4 · Total yield 1.46kg(Bromfenac (Free))
Bromfenac Sodium-0015467-74-3Bromfenac Sodium-0021885-29-6Bromfenac Sodium-0031140-17-6Bromfenac Sodium-0044455-13-4Bromfenac Sodium-00591713-90-5Bromfenac Sodium-00691713-91-6Bromfenac Sodium-00791714-94-2,91714-93-1API · Bromfenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Bromfenac Sodium-001 | 5467-74-3 | para-Bromobenzeneboronic acid |
| Bromfenac Sodium-002 | 1885-29-6 | Anthranilonitrile |
| Bromfenac Sodium-003 | 1140-17-6 | 2-Amino-4'-bromobenzophenone |
| Bromfenac Sodium-004 | 4455-13-4 | Ethyl alpha-(methylthio)acetate |
| Bromfenac Sodium-005 | 91713-90-5 | 7-(4-Bromobenzoyl)-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one |
| Bromfenac Sodium-006 | 91713-91-6 | 7-(4-Bromobenzoyl)-1,3-dihydro-2-indolone |
| Bromfenac Sodium-007 | 91714-94-2,91714-93-1 | [2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid |
ProcessRoute 2Steps 7 · Total yield 0.963kg(Bromfenac Sodium (API))
Bromfenac Sodium-00891714-50-0Bromfenac Sodium-00991714-51-1Bromfenac Sodium-0101279501-08-4Bromfenac Sodium-00691713-91-6Bromfenac Sodium-0112761367-02-4Bromfenac Sodium-0121797880-03-5Bromfenac Sodium-00791714-94-2,91714-93-1API · Bromfenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Bromfenac Sodium-008 | 91714-50-0 | (4-Bromophenyl)(7-indolyl)methanone |
| Bromfenac Sodium-009 | 91714-51-1 | (4-Bromophenyl)(3-chloro-1H-indol-7-yl)methanone |
| Bromfenac Sodium-010 | 1279501-08-4 | (3-Bromo-1H-indol-7-yl)(4-bromophenyl)methanone |
| Bromfenac Sodium-006 | 91713-91-6 | 7-(4-Bromobenzoyl)-1,3-dihydro-2-indolone |
| Bromfenac Sodium-011 | 2761367-02-4 | 7-(4-Bromobenzoyl)-3,3-dichloro-1,3-dihydro-2H-indol-2-one |
| Bromfenac Sodium-012 | 1797880-03-5 | 3,3-Dibromo-7-(4-bromobenzoyl)-1,3-dihydro-2H-indol-2-one |
| Bromfenac Sodium-007 | 91714-94-2,91714-93-1 | [2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid |
ProcessRoute 3Steps 7 · Total yield 493g(Bromfenac Sodium (API))
Bromfenac Sodium-013120-72-9Bromfenac Sodium-0141484-27-1Bromfenac Sodium-01559-48-3Bromfenac Sodium-016623-00-7Bromfenac Sodium-00691713-91-6Bromfenac Sodium-00791714-94-2,91714-93-1Bromfenac Sodium-01751579-82-9,61618-27-7Bromfenac Sodium-01851579-82-9API · Bromfenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Bromfenac Sodium-013 | 120-72-9Available | 1H-Indole |
| Bromfenac Sodium-014 | 1484-27-1 | 3-Bromoindole |
| Bromfenac Sodium-015 | 59-48-3 | 1,3-Dihydroindolone |
| Bromfenac Sodium-016 | 623-00-7 | 4-Bromobenzonitrile |
| Bromfenac Sodium-006 | 91713-91-6 | 7-(4-Bromobenzoyl)-1,3-dihydro-2-indolone |
| Bromfenac Sodium-007 | 91714-94-2,91714-93-1 | [2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid |
| Bromfenac Sodium-017 | 51579-82-9,61618-27-7 | 2-Amino-3-benzoylbenzeneacetic acid sodium salt monohydrate |
| Bromfenac Sodium-018 | 51579-82-9 | (2-Amino-3-benzoylphenyl)acetic acid |
ProcessRoute 9Steps 1 · Total yield 1.16kg(Bromfenac Sodium-048)
Bromfenac Sodium-00891714-50-0Bromfenac Sodium-0482761367-03-5API · Bromfenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| Bromfenac Sodium-008 | 91714-50-0 | (4-Bromophenyl)(7-indolyl)methanone |
| Bromfenac Sodium-048 | 2761367-03-5 | 7-(4-Bromobenzoyl)-3,3-diiodo-1,3-dihydro-2H-indol-2-one |
Frequently asked questions
What are the approved indications of Bromfenac Sodium?
Approved indications include: Inflammatory disease, Postoperative pain, 眼睛发炎, 眼睛疼痛.
When does the Bromfenac Sodium patent expire?
No public expiry year is available for Bromfenac Sodium yet; this page updates once verified.
How many synthesis routes are recorded for Bromfenac Sodium?
9 synthesis routes are recorded; the shortest is 1 steps with 1.16kg(Bromfenac Sodium-048) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Bromfenac Sodium intermediates?
7 intermediate CAS of Bromfenac Sodium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Bromfenac Sodium intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29