Clarithromycin/Rabeprazole Sodium/Amoxicillin

Tier C — Watch / trade

Eisai Co., Ltd.

Originator

2013

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：50S ribosomal subunit, Proton pump, PBPs

Brand：Rabecure

Indications (approved)：Marginal zone B-cell lymphoma, Duodenal ulcer, Immune thrombocytopenic purpura, Gastric ulcer, Gastritis, Helicobacter pylori infection

Regional status

China

Japan

Approved

2013-08-15

Factories producing this API10

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

10 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates20 routes

Originator routes × 1Optimised (non-patent) × 18Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield 530 mg

RABE-0011589-49-7RABE-00259886-90-7RABE-003117977-18-1RABE-004117977-20-5RABE-005583-39-1RABE-006117977-21-6API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
RABE-001	1589-49-7	3-methoxypropan-1-ol
RABE-002	59886-90-7	4-chloro-2,3-dimethylpyridine 1-oxide
RABE-003	117977-18-1	4-(3-methoxypropoxy)-2,3-dimethylpyridine 1-oxide
RABE-004	117977-20-5	2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine
RABE-005	583-39-1	1H-benzo[d]imidazole-2-thiol
RABE-006	117977-21-6	2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole

OptimisedRoute 1Steps 6 · Total yield /

Amoxicillin-001922-68-9Amoxicillin-0022627-86-3Amoxicillin-0033082-62-0Amoxicillin-004—Amoxicillin-005—Amoxicillin-006108-95-2Amoxicillin-007—Amoxicillin-008—Amoxicillin-009—Amoxicillin-010—Amoxicillin-01157591-61-4Amoxicillin-01237763-23-8Amoxicillin-013551-16-6API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Amoxicillin-001	922-68-9	Methyl glyoxylate
Amoxicillin-002	2627-86-3	(S)-(-)-1-Phenylethylamine
Amoxicillin-003	3082-62-0	(1S)-1-(2-Naphthyl)ethanamine
Amoxicillin-004	-	Methyl (2Z)-[[(1S)-1-phenylethyl]imino]acetate
Amoxicillin-005	-	Methyl (2Z)-[[(1S)-1-(naphthalen-2-yl)ethyl]imino]acetate
Amoxicillin-006	108-95-2 Available	Carbolic acid
Amoxicillin-007	-	Methyl (2R)-(4-hydroxyphenyl)[(1-phenylethyl)amino]acetate
Amoxicillin-008	-	Methyl (2R)-(4-hydroxyphenyl)[[1-(naphthalen-2-yl)ethyl]amino]acetate
Amoxicillin-009	-	Methyl (2R)-(4-hydroxyphenyl)[(1-phenylethyl)amino]acetate hydrogen chloride (1/1)
Amoxicillin-010	-	Methyl (2R)-(4-hydroxyphenyl)[[1-(naphthalen-2-yl)ethyl]amino]acetate hydrogen chloride (1/1)
Amoxicillin-011	57591-61-4	D-p-Hydroxyphenylglycine methyl ester hydrochloride
Amoxicillin-012	37763-23-8	D-p-yHdroxyphenylglycine methyl ester
Amoxicillin-013	551-16-6 Available	(+)-6-Aminopenicillanic acid

OptimisedRoute 2Steps 4 · Total yield /

Amoxicillin-01436747-66-7Amoxicillin-01526787-75-7Amoxicillin-013551-16-6Amoxicillin-01676953-81-6Amoxicillin-017—API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Amoxicillin-014	36747-66-7	[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid
Amoxicillin-015	26787-75-7	(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid
Amoxicillin-013	551-16-6 Available	(+)-6-Aminopenicillanic acid
Amoxicillin-016	76953-81-6	(2S,5R,6R)-6-[[(2R)-2-[[(Benzyloxy)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Amoxicillin-017	-	Sodium (2S,5R,6R)-6-[[(2R)-2-[[(benzyloxy)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

OptimisedRoute 3Steps 5 · Total yield /

Amoxicillin-01526787-75-7Amoxicillin-01822818-40-2Amoxicillin-019105-45-3Amoxicillin-020—Amoxicillin-021—Amoxicillin-022—Amoxicillin-013551-16-6API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Amoxicillin-015	26787-75-7	(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid
Amoxicillin-018	22818-40-2	(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid
Amoxicillin-019	105-45-3 Available	1-Methoxybutane-1,3-dione
Amoxicillin-020	-	Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate
Amoxicillin-021	-	Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Amoxicillin-022	-	Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Amoxicillin-013	551-16-6 Available	(+)-6-Aminopenicillanic acid

OptimisedRoute 4Steps 6 · Total yield /

Amoxicillin-01526787-75-7Amoxicillin-02126889-95-2Amoxicillin-013551-16-6Amoxicillin-02228645-17-2Amoxicillin-01822818-40-2Amoxicillin-02351431-08-4API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Amoxicillin-015	26787-75-7	(2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid
Amoxicillin-021	26889-95-2	(2R)-[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid
Amoxicillin-013	551-16-6 Available	(+)-6-Aminopenicillanic acid
Amoxicillin-022	28645-17-2	(2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Amoxicillin-018	22818-40-2	(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid
Amoxicillin-023	51431-08-4	(2R)-Amino(4-hydroxyphenyl)acetyl chloride hydrogen chloride

OptimisedRoute 5Steps 3 · Total yield /

Amoxicillin-02432401-82-4Amoxicillin-013551-16-6Amoxicillin-02553726-38-8Amoxicillin-026—Amoxicillin-02738083-36-2API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Amoxicillin-024	32401-82-4	[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid
Amoxicillin-013	551-16-6 Available	(+)-6-Aminopenicillanic acid
Amoxicillin-025	53726-38-8	(2S,5R,6R)-6-[[[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Amoxicillin-026	-	Sodium (2S,5R,6R)-6-[[[[(benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Amoxicillin-027	38083-36-2	(2S,5R,6R)-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

OptimisedRoute 6Steps 3 · Total yield /

Amoxicillin-01822818-40-2Amoxicillin-028178119-93-2Amoxicillin-013551-16-6Amoxicillin-0292171277-86-2API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Amoxicillin-018	22818-40-2	(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid
Amoxicillin-028	178119-93-2	(2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid
Amoxicillin-013	551-16-6 Available	(+)-6-Aminopenicillanic acid
Amoxicillin-029	2171277-86-2	(2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

OptimisedRoute 7Steps 1 · Total yield /

Amoxicillin-030113-98-4Amoxicillin-03147294-44-0,47294-41-7,70019-71-5,61-33-6,30411-69-9,7005-30-3Amoxicillin-01157591-61-4Amoxicillin-01237763-23-8Amoxicillin-03254397-23-8API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Amoxicillin-030	113-98-4	(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium salt
Amoxicillin-031	47294-44-0,47294-41-7,70019-71-5,61-33-6,30411-69-9,7005-30-3	(2S-(2alpha,5alpha,6beta))-3,3-Dimethyl-7-oxo-6-((phenylacetyl)amino)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
Amoxicillin-011	57591-61-4	D-p-Hydroxyphenylglycine methyl ester hydrochloride
Amoxicillin-012	37763-23-8	D-p-yHdroxyphenylglycine methyl ester
Amoxicillin-032	54397-23-8	(2R)-2-Amino-2-(4-hydroxyphenyl)acetamide

OptimisedRoute 2Steps 3 · Total yield 40.32 kg

RABE-005583-39-1RABE-006117977-21-6RABE-007153259-31-5RABE-008117976-89-3API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
RABE-005	583-39-1	1H-benzo[d]imidazole-2-thiol
RABE-006	117977-21-6	2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
RABE-007	153259-31-5	2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride
RABE-008	117976-89-3	2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole

OptimisedRoute 3Steps 1 · Total yield /

RABE-006117977-21-6API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
RABE-006	117977-21-6	2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole

OptimisedRoute 4Steps 1 · Total yield 92.4 g

RABE-005583-39-1RABE-009117977-20-5API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
RABE-005	583-39-1	1H-benzo[d]imidazole-2-thiol
RABE-009	117977-20-5	2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine

OptimisedRoute 5Steps 2 · Total yield /

RABE-004117977-20-5RABE-005583-39-1RABE-008117976-89-3RABE-010924663-39-8API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
RABE-004	117977-20-5	2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine
RABE-005	583-39-1	1H-benzo[d]imidazole-2-thiol
RABE-008	117976-89-3	2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
RABE-010	924663-39-8	2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide

OptimisedRoute 1Steps 3 · Total yield 6g(Clarithromycin (Free))

Clarithromycin-001—Clarithromycin-002—Clarithromycin-003—API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Clarithromycin-001	-	benzyl (2S,3R,4S,6R)-4-{[(benzyloxy)carbonyl](methyl)amino}-2-{[(3R,4S,5S,6R,7S,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradecan-6-yl]oxy}-6-methyloxan-3-yl carbonate
Clarithromycin-002	-	benzyl (2S,3R,4S,6R)-4-{[(benzyloxy)carbonyl](methyl)amino}-2-{[(3R,4S,5S,6R,7S,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradecan-6-yl]oxy}-6-methyloxan-3-yl carbonate
Clarithromycin-003	-	(3R,4S,5S,6R,7S,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-6-{[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)oxan-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione

OptimisedRoute 3Steps 4 · Total yield 18g(Clarithromycin (Free))

Clarithromycin-006133445-26-8Clarithromycin-007887125-82-8Clarithromycin-008—Clarithromycin-009—Clarithromycin-010—Clarithromycin-011133415-69-7API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Clarithromycin-006	133445-26-8	(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydrpyran-2-yloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(1-isopropoxycyclohexyl)oxime]
Clarithromycin-007	887125-82-8	Acetic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-6-methyltetrahydropyran-3-yl ester
Clarithromycin-008	-	Benzoic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-6-methyltetrahydropyran-3-yl ester
Clarithromycin-009	-	Benzoic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-6-methyltetrahydropyran-3-yl ester
Clarithromycin-010	-	Acetic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-6-methyltetrahydropyran-3-yl ester
Clarithromycin-011	133415-69-7	(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(1-isopropoxycyclohexyl)oxime]

OptimisedRoute 4Steps 5 · Total yield 4.2g(Clarithromycin (Free))

Clarithromycin-01213127-18-9Clarithromycin-013611-19-8Clarithromycin-014206997-62-8Clarithromycin-0151395892-49-5Clarithromycin-016—Clarithromycin-017—Clarithromycin-018—Clarithromycin-019149882-99-5API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Clarithromycin-012	13127-18-9	(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
Clarithromycin-013	611-19-8	2-Chlorobenzyl chloride
Clarithromycin-014	206997-62-8	(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-7,12,13-trihydroxy-4- [(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime]
Clarithromycin-015	1395892-49-5	Acetic acid (2S,3R,4S,6R)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester
Clarithromycin-016	-	Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester
Clarithromycin-017	-	Acetic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester
Clarithromycin-018	-	Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester
Clarithromycin-019	149882-99-5	(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime]

OptimisedRoute 5Steps 1 · Total yield /

Clarithromycin-01213127-18-9API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Clarithromycin-012	13127-18-9	(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one

OptimisedRoute 6Steps 5 · Total yield 17.5g(Clarithromycin (Free))

Clarithromycin-0207704-67-8Clarithromycin-01213127-18-9Clarithromycin-02113127-18-9Clarithromycin-022926-66-9Clarithromycin-023—Clarithromycin-0241253181-38-2Clarithromycin-02574-88-4Clarithromycin-02674-83-9Clarithromycin-0271253181-39-3API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Clarithromycin-020	7704-67-8	(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione thiocyanate
Clarithromycin-012	13127-18-9	Thiocyanic acid--(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one (1/1)
Clarithromycin-021	13127-18-9	(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
Clarithromycin-022	926-66-9	2-Ethoxyprop-1-ene
Clarithromycin-023	-	(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one
Clarithromycin-024	1253181-38-2	(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-([(2S,3R,4S,6R)-4-(Dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-([(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
Clarithromycin-025	74-88-4 Available	Methyl iodide
Clarithromycin-026	74-83-9	Bromomethane
Clarithromycin-027	1253181-39-3	(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-([(2S,3R,4S,6R)-4-(Dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-12,13-dihydroxy-7-methoxy-4-([(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one

OptimisedRoute 7Steps 2 · Total yield 52g(Clarithromycin-028)

Clarithromycin-01213127-18-9Clarithromycin-022926-66-9Clarithromycin-023—Clarithromycin-028—API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Clarithromycin-012	13127-18-9	(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
Clarithromycin-022	926-66-9	2-Ethoxyprop-1-ene
Clarithromycin-023	-	(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one
Clarithromycin-028	-	(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-([(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]oxan-2-yl]oxy)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one

OptimisedRoute 8Steps 1 · Total yield 88g(Clarithromycin-012)

Clarithromycin-0207704-67-8Clarithromycin-01213127-18-9API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Clarithromycin-020	7704-67-8	(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione thiocyanate
Clarithromycin-012	13127-18-9	(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one

ProcessRoute 2Steps 2 · Total yield 429.768g(Clarithromycin (Free))

Clarithromycin-004—Clarithromycin-005—API · Clarithromycin/Rabeprazole Sodium/Amoxicillin

Code	CAS No.	Intermediate
Clarithromycin-004	-	(2R,3R,4R,5R,6R,8R,9E,10S,11R,12R,13S)-5-{[(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-13-ethyl-6,11,12-trihydroxy-3-{[(4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-9-{[(2-methoxypropan-2-yl)oxy]imino}-2,4,6,8,10,12-hexamethylcyclotetradecan-1-one
Clarithromycin-005	-	(2R,3R,4R,5R,6R,8R,9E,10S,11R,12R,13S)-5-{[(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-13-ethyl-11,12-dihydroxy-6-methoxy-3-{[(4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-9-{[(2-methoxypropan-2-yl)oxy]imino}-2,4,6,8,10,12-hexamethylcyclotetradecan-1-one

Frequently asked questions

What are the approved indications of Clarithromycin/Rabeprazole Sodium/Amoxicillin?

Approved indications include: Marginal zone B-cell lymphoma, Duodenal ulcer, Immune thrombocytopenic purpura, Gastric ulcer, Gastritis, Helicobacter pylori infection.

When does the Clarithromycin/Rabeprazole Sodium/Amoxicillin patent expire?

No public expiry year is available for Clarithromycin/Rabeprazole Sodium/Amoxicillin yet; this page updates once verified.

How many synthesis routes are recorded for Clarithromycin/Rabeprazole Sodium/Amoxicillin?

20 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Clarithromycin/Rabeprazole Sodium/Amoxicillin intermediates?

4 intermediate CAS of Clarithromycin/Rabeprazole Sodium/Amoxicillin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Clarithromycin/Rabeprazole Sodium/Amoxicillin intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29