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Memantine Hydrochloride

Tier B — Position early

Memantine Hydrochloride

Merz Pharma
Originator
2002
First approval
-
Expiry (public)
$2.25B ▲
Peak sales
Small molecule
Type

Targets:NMDAR

Brand:Balaxur, Axura, Memary, Namenda, Akatinol, Ebixa

Indications (approved):Alzheimer's disease

Regional status

US
Phase III
2002-06-01
EU
Approved
2002-05-15
China
Approved
2006-09-12
Japan
Approved
2011-01-21

Factories producing this API2

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 3 · Total yield 3.5 g
MEMA-001702-79-4MEMA-002941-37-7MEMA-00319982-07-1API · Memantine Hydrochloride
CodeCAS No.Intermediate
MEMA-001702-79-4(1r,3r,5s,7s)-1,3-dimethyladamantane
MEMA-002941-37-7(1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane
MEMA-00319982-07-1N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)acetamide
OptimisedRoute 2Steps 2 · Total yield 61 g
MEMA-002941-37-7API · Memantine Hydrochloride
CodeCAS No.Intermediate
MEMA-002941-37-7(1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane
OptimisedRoute 3Steps 4 · Total yield 58 g
MEMA-004707-37-9MEMA-005707-36-8MEMA-006351329-88-9MEMA-001702-79-4API · Memantine Hydrochloride
CodeCAS No.Intermediate
MEMA-004707-37-9(1r,3R,5S,7r)-3,5-dimethyladamantan-1-ol
MEMA-005707-36-8(1r,3R,5S,7r)-1-chloro-3,5-dimethyladamantane
MEMA-006351329-88-9N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)formamide
MEMA-001702-79-4(1r,3r,5s,7s)-1,3-dimethyladamantane
OptimisedRoute 4Steps 2 · Total yield 320 g
MEMA-001702-79-4MEMA-00319982-07-1API · Memantine Hydrochloride
CodeCAS No.Intermediate
MEMA-001702-79-4(1r,3r,5s,7s)-1,3-dimethyladamantane
MEMA-00319982-07-1N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)acetamide
OptimisedRoute 5Steps 3 · Total yield 8.8 g
MEMA-002941-37-7MEMA-0071074-82-4MEMA-0081204184-74-6API · Memantine Hydrochloride
CodeCAS No.Intermediate
MEMA-002941-37-7(1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane
MEMA-0071074-82-4potassium 1,3-dioxoisoindolin-2-ide
MEMA-0081204184-74-62-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)isoindoline-1,3-dione

Frequently asked questions

What are the approved indications of Memantine Hydrochloride?

Approved indications include: Alzheimer's disease.

When does the Memantine Hydrochloride patent expire?

No public expiry year is available for Memantine Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Memantine Hydrochloride?

5 synthesis routes are recorded; the shortest is 2 steps with 61 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Memantine Hydrochloride intermediates?

All intermediates in Memantine Hydrochloride routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Memantine Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29