Epinephrine intranasal spray (ARS Pharmaceuticals)

Tier C — Watch / trade

ARS Pharmaceuticals Inc

Originator

2024

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：β-adrenoceptors, α-adrenoceptors

Brand：Neffy, EUR neffy, EURneffy

Indications (approved)：Allergic reaction

Regional status

Approved

2024-08-09

Approved

2024-06-28

China

Approved

2025-12-22

Japan

Approved

2025-09-19

Synthetic routes & intermediates7 routes

Originator routes × 0Optimised (non-patent) × 7Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 2 · Total yield /

(I)275500-1-a54917-85-0(II)275500-1-a107-97-1(III)275500-1-a1510840-02-4API · Epinephrine intranasal spray (ARS Pharmaceuticals)

Code	CAS No.	Intermediate
(I)275500-1-a	54917-85-0	4-Formyl-1,2-phenylene dibenzoate
(II)275500-1-a	107-97-1	(Methylamino)ethanoic acid
(III)275500-1-a	1510840-02-4	4-(3-Methyl-1,3-oxazolidin-5-yl)-1,2-phenylene dibenzoate

OptimisedRoute 2Steps 3 · Total yield /

(I)275500-2-a120-80-9(II)275500-2-a79-04-9(III)275500-2-a99-40-1(IV)275500-2-a103-67-3(V)275500-2-a36467-25-1(VI)275500-2-a329-65-7(VII)275500-2-a150-05-0(VIII)275500-2-a5985-28-4(IX)275500-2-a66632-18-6(X)275500-2-a87697-27-6API · Epinephrine intranasal spray (ARS Pharmaceuticals)

Code	CAS No.	Intermediate
(I)275500-2-a	120-80-9	1,2-Dihydroxybenzene
(II)275500-2-a	79-04-9 Available	2-Chloranylethanoyl chloride
(III)275500-2-a	99-40-1	2-Chloro-1-(3,4-dihydroxyphenyl)ethanone
(IV)275500-2-a	103-67-3	N-Benzyl-N-methylamine
(V)275500-2-a	36467-25-1	2-[Benzyl(methyl)amino]-1-(3,4-dihydroxyphenyl)ethan-1-one
(VI)275500-2-a	329-65-7	(±)-2-(3,4-Dihydroxyphenyl)-2-hydroxy-N-methylethylamine
(VII)275500-2-a	150-05-0	(+)-4-[1(S)-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(VIII)275500-2-a	5985-28-4	4-[1-Hydroxy-2-(methylamino)ethyl]phenol hydrogen chloride
(IX)275500-2-a	66632-18-6	N-Boc-synephrine
(X)275500-2-a	87697-27-6	N-Boc-racepinephrine

OptimisedRoute 3Steps 2 · Total yield /

(I)275500-3-a99-45-6(II)275500-3-a65279-36-9API · Epinephrine intranasal spray (ARS Pharmaceuticals)

Code	CAS No.	Intermediate
(I)275500-3-a	99-45-6	1-(3,4-Dihydroxyphenyl)-2-(methylamino)ethanone
(II)275500-3-a	65279-36-9	2-Acetoxy-4-[2-(methylamino)acetyl]phenyl acetate

OptimisedRoute 4Steps 3 · Total yield /

(I)275500-4-a99-40-1(II)275500-4-a74-89-5(III)275500-4-a62-13-5(IV)275500-4-a329-65-7API · Epinephrine intranasal spray (ARS Pharmaceuticals)

Code	CAS No.	Intermediate
(I)275500-4-a	99-40-1	2-Chloro-1-(3,4-dihydroxyphenyl)ethanone
(II)275500-4-a	74-89-5	Aminomethane
(III)275500-4-a	62-13-5	1-(3,4-Dihydroxyphenyl)-2-(methylamino)ethan-1-one hydrochloride
(IV)275500-4-a	329-65-7	(±)-2-(3,4-Dihydroxyphenyl)-2-hydroxy-N-methylethylamine

OptimisedRoute 5Steps 5 · Total yield /

(I)275500-5-a120-80-9(II)275500-5-a53270-13-6(III)275500-5-a2243120-32-1(IV)275500-5-a79-04-9(V)275500-5-a2243120-33-2(VI)275500-5-a74-89-5(VII)275500-5-a2243120-34-3(VIII)275500-5-a2243120-35-4API · Epinephrine intranasal spray (ARS Pharmaceuticals)

Code	CAS No.	Intermediate
(I)275500-5-a	120-80-9	1,2-Dihydroxybenzene
(II)275500-5-a	53270-13-6	2-O-Acetyl-3,4,6-tri-O-benzyl-alpha-D-glucopyranosyl bromide
(III)275500-5-a	2243120-32-1	2-Hydroxyphenyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranoside
(IV)275500-5-a	79-04-9 Available	2-Chloranylethanoyl chloride
(V)275500-5-a	2243120-33-2	4-(Chloroacetyl)-2-hydroxyphenyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranoside
(VI)275500-5-a	74-89-5	Aminomethane
(VII)275500-5-a	2243120-34-3	2-Hydroxy-4-[(methylamino)acetyl]phenyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranoside
(VIII)275500-5-a	2243120-35-4	2-Hydroxy-4-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranoside

OptimisedRoute 6Steps 4 · Total yield /

(I)275500-6-a120-80-9(II)275500-6-a79-04-9(III)275500-6-a99-40-1(IV)275500-6-a955396-11-9(V)275500-6-a51-41-2(VI)275500-6-a74-89-5API · Epinephrine intranasal spray (ARS Pharmaceuticals)

Code	CAS No.	Intermediate
(I)275500-6-a	120-80-9	1,2-Dihydroxybenzene
(II)275500-6-a	79-04-9 Available	2-Chloranylethanoyl chloride
(III)275500-6-a	99-40-1	2-Chloro-1-(3,4-dihydroxyphenyl)ethanone
(IV)275500-6-a	955396-11-9	4-[(1R)-2-Chloro-1-hydroxyethyl]benzene-1,2-diol
(V)275500-6-a	51-41-2	(-)-4-[2-Amino-1(R)-hydroxyethyl]-1,2-benzenediol
(VI)275500-6-a	74-89-5	Aminomethane

OptimisedRoute 7Steps 1 · Total yield /

(I)275500-7-a99-40-1(II)275500-7-a1385789-37-6API · Epinephrine intranasal spray (ARS Pharmaceuticals)

Code	CAS No.	Intermediate
(I)275500-7-a	99-40-1	2-Chloro-1-(3,4-dihydroxyphenyl)ethanone
(II)275500-7-a	1385789-37-6	4-[(1S)-2-Chloro-1-hydroxyethyl]benzene-1,2-diol

Frequently asked questions

What are the approved indications of Epinephrine intranasal spray (ARS Pharmaceuticals)?

Approved indications include: Allergic reaction.

When does the Epinephrine intranasal spray (ARS Pharmaceuticals) patent expire?

No public expiry year is available for Epinephrine intranasal spray (ARS Pharmaceuticals) yet; this page updates once verified.

How many synthesis routes are recorded for Epinephrine intranasal spray (ARS Pharmaceuticals)?

7 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Epinephrine intranasal spray (ARS Pharmaceuticals) intermediates?

1 intermediate CAS of Epinephrine intranasal spray (ARS Pharmaceuticals) are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Epinephrine intranasal spray (ARS Pharmaceuticals) intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29