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Betamethasone Dipropionate/Calcipotriol
Tier C — Watch / tradeBetamethasone Dipropionate/Calcipotriol
Mc2 Therapeutics Ltd
Originator
2006
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：GR, VDR
Indications (approved)：Plaque psoriasis, Psoriasis
Regional status
US
Approved
2006-01-09
EU
Approved
2022-02-22
China
Phase III
2025-12-30
Japan
No progress
2019-01-24
Factories producing this API11
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
11 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 15 · Total yield 483 mg (Calcipotriol)
CALCIP-00150-14-6CALCIP-00287680-65-7CALCIP-003170081-43-3CALCIP-00460123-29-7CALCIP-005112670-78-7CALCIP-006111594-58-2CALCIP-0072170464-36-3CALCIP-008—CALCIP-009—CALCIP-0107691-76-1CALCIP-011112849-17-9CALCIP-012112849-27-1CALCIP-013112849-27-1CALCIP-014765-43-5CALCIP-01569267-75-0CALCIP-016112849-15-7API · Betamethasone Dipropionate/Calcipotriol
| Code | CAS No. | Intermediate |
|---|---|---|
| CALCIP-001 | 50-14-6Available | (S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol |
| CALCIP-002 | 87680-65-7Available | (6S)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)-6-hydroxy-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide |
| CALCIP-003 | 170081-43-3Available | 2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal |
| CALCIP-004 | 60123-29-7Available | tert-butyl(((S,E)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)dimethylsilane |
| CALCIP-005 | 112670-78-7Available | (1S,5R,E)-5-((tert-butyldimethylsilyl)oxy)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-methylenecyclohexanol |
| CALCIP-006 | 111594-58-2Available | (((1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane) |
| CALCIP-007 | 2170464-36-3Available | (4S,6R)-4,6-bis((tert-butyldimethylsilyl)oxy)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)octahydrobenzo[c]thiophene 2,2-dioxide |
| CALCIP-008 | - | (2S)-2-((1R,3aS,7aR,E)-4-(((4S,6R)-4,6-bis((tert-butyldimethylsilyl)oxy)-2,2-dioxidooctahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal |
| CALCIP-009 | - | 2-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)propanal |
| CALCIP-010 | 7691-76-1Available | 1-cyclopropyl-2-(triphenylphosphoranylidene)ethanone |
| CALCIP-011 | 112849-17-9Available | (R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one |
| CALCIP-012 | 112849-27-1Available | (1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol |
| CALCIP-013 | 112849-27-1Available | (1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol |
| CALCIP-014 | 765-43-5Available | 1-cyclopropylethanone |
| CALCIP-015 | 69267-75-0Available | 2-bromo-1-cyclopropylethanone |
| CALCIP-016 | 112849-15-7Available | - |
OptimisedRoute 1Steps 3 · Total yield 10.95 g
BETA-001—BETA-002—Betamethasone—API · Betamethasone Dipropionate/Calcipotriol
| Code | CAS No. | Intermediate |
|---|---|---|
| BETA-001 | - | (8S,9R,10S,13S,14S,16S,17R)-2'-ethoxy-2'-ethyl-9-fluoro-11-hydroxy-10,13,16-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxane]-3,5'(6H)-dione |
| BETA-002 | - | (8S,9R,10S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate |
| Betamethasone | - | (8S,9R,10S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
OptimisedRoute 2Steps 3 · Total yield 89 mg (Calcipotriol)
CALCIP-017223538-02-1CALCIP-0181099618-83-3CALCIP-0191099618-85-5CALCIP-0201099618-87-7API · Betamethasone Dipropionate/Calcipotriol
| Code | CAS No. | Intermediate |
|---|---|---|
| CALCIP-017 | 223538-02-1Available | (((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((S)-1-(phenylsulfonyl)propan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane) |
| CALCIP-018 | 1099618-83-3Available | (S)-2-((tert-butyldiphenylsilyl)oxy)-2-cyclopropylacetaldehyde |
| CALCIP-019 | 1099618-85-5Available | (1S,4S)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-((tert-butyldiphenylsilyl)oxy)-1-cyclopropyl-3-(phenylsulfonyl)pentan-2-ol |
| CALCIP-020 | 1099618-87-7Available | (((1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-((tert-butyldiphenylsilyl)oxy)-5-cyclopropylpent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane) |
OptimisedRoute 3Steps 12 · Total yield 22.6 g (Calcipotriol)
CALCIP-00150-14-6CALCIP-00287680-65-7CALCIP-003170081-43-3CALCIP-021170081-43-3CALCIP-0221329004-02-5CALCIP-023—CALCIP-024—CALCIP-025—CALCIP-0107691-76-1CALCIP-026—CALCIP-027—CALCIP-011112849-17-9CALCIP-012112849-27-1CALCIP-013112849-27-1API · Betamethasone Dipropionate/Calcipotriol
| Code | CAS No. | Intermediate |
|---|---|---|
| CALCIP-001 | 50-14-6Available | (S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol |
| CALCIP-002 | 87680-65-7Available | (6S)-1-((E)-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)methyl)-6-hydroxy-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide |
| CALCIP-003 | 170081-43-3Available | 2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal |
| CALCIP-021 | 170081-43-3Available | 2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal |
| CALCIP-022 | 1329004-02-5Available | 2-((1R,3aS,7aR,E)-4-((E)-2-((S)-5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)propanal |
| CALCIP-023 | - | - |
| CALCIP-024 | - | - |
| CALCIP-025 | - | - |
| CALCIP-010 | 7691-76-1Available | 1-cyclopropyl-2-(triphenylphosphoranylidene)ethanone |
| CALCIP-026 | - | - |
| CALCIP-027 | - | - |
| CALCIP-011 | 112849-17-9Available | (R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-one |
| CALCIP-012 | 112849-27-1Available | (1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol |
| CALCIP-013 | 112849-27-1Available | (1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol |
OptimisedRoute 4Steps 9 · Total yield 198 mg (Calcipotriol)
CALCIP-0281342554-01-1CALCIP-029—CALCIP-030—CALCIP-0311971117-00-6CALCIP-0321971117-03-9CALCIP-033149-30-4CALCIP-0341971117-04-0CALCIP-0351971117-11-9CALCIP-036112828-13-4CALCIP-0381971117-18-6CALCIP-0371971117-18-6API · Betamethasone Dipropionate/Calcipotriol
| Code | CAS No. | Intermediate |
|---|---|---|
| CALCIP-028 | 1342554-01-1Available | - |
| CALCIP-029 | - | - |
| CALCIP-030 | - | - |
| CALCIP-031 | 1971117-00-6Available | - |
| CALCIP-032 | 1971117-03-9Available | - |
| CALCIP-033 | 149-30-4Available | - |
| CALCIP-034 | 1971117-04-0Available | - |
| CALCIP-035 | 1971117-11-9Available | - |
| CALCIP-036 | 112828-13-4Available | - |
| CALCIP-038 | 1971117-18-6Available | benzyl ((1S,4R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-yl) carbonate |
| CALCIP-037 | 1971117-18-6Available | benzyl ((1S,4R,E)-4-((1R,3aS,7aR,E)-4-((E)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-yl) carbonate |
Frequently asked questions
What are the approved indications of Betamethasone Dipropionate/Calcipotriol?
Approved indications include: Plaque psoriasis, Psoriasis.
When does the Betamethasone Dipropionate/Calcipotriol patent expire?
No public expiry year is available for Betamethasone Dipropionate/Calcipotriol yet; this page updates once verified.
How many synthesis routes are recorded for Betamethasone Dipropionate/Calcipotriol?
5 synthesis routes are recorded; the shortest is 3 steps with 10.95 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Betamethasone Dipropionate/Calcipotriol intermediates?
26 intermediate CAS of Betamethasone Dipropionate/Calcipotriol are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Betamethasone Dipropionate/Calcipotriol intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29