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Formoterol Fumarate/Glycopyrrolate
Tier C — Watch / tradeFormoterol Fumarate/Glycopyrrolate
AstraZeneca
Originator
2016
First approval
-
Expiry (public)
$0.06B ▲
Peak sales
Small molecule
Type
Targets：mAChRs, ADRB2
Brand：Bevespi Aerosphere
Indications (approved)：Chronic obstructive pulmonary disease
Regional status
US
Approved
2016-04-25
EU
Approved
2018-12-18
China
Approved
2020-05-12
Japan
Approved
2019-06-18
Factories producing this API12
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
12 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates8 routes
Originator routes × 0Optimised (non-patent) × 8Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 8 · Total yield 500mg(Formoterol Fumarate (API))
Formoterol Fumarate-001—Formoterol Fumarate-002—Formoterol Fumarate-003—Formoterol Fumarate-004—Formoterol Fumarate-0051199228-78-8Formoterol Fumarate-006—Formoterol Fumarate-007—Formoterol Fumarate-008—Formoterol Fumarate-009—Formoterol Fumarate-010—Formoterol Fumarate-011—Formoterol Fumarate-012—API · Formoterol Fumarate/Glycopyrrolate
| Code | CAS No. | Intermediate |
|---|---|---|
| Formoterol Fumarate-001 | - | 1-(4-Hydroxy-3-nitrophenyl)ethan-1-one |
| Formoterol Fumarate-002 | - | 1-(4-(Benzyloxy)-3-nitrophenyl)ethanone |
| Formoterol Fumarate-003 | - | 1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone |
| Formoterol Fumarate-004 | - | (2R*)-N-Benzyl-1-(4-methoxyphenyl)propan-2-amine |
| Formoterol Fumarate-005 | 1199228-78-8 | (2R)-N-Benzyl-1-(4-methoxyphenyl)propan-2-amine hydrogen chloride |
| Formoterol Fumarate-006 | - | 2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanone |
| Formoterol Fumarate-007 | - | (1R*)-2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanol |
| Formoterol Fumarate-008 | - | (1R*)-1-[3-Amino-4-(benzyloxy)phenyl]-2-[benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]ethanol |
| Formoterol Fumarate-009 | - | Acido formico |
| Formoterol Fumarate-010 | - | Amide c1 |
| Formoterol Fumarate-011 | - | N-[5-[(1R*)-2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-hydroxyethyl]-2-(benzyloxy)phenyl]formamide |
| Formoterol Fumarate-012 | - | N-[2-Hydroxy-5-[1(R*)-hydroxy-2-[1(R*)-methyl-2-(4-methoxyphenyl)ethylamino]ethyl]phenyl]formamide |
OptimisedRoute 2Steps 1 · Total yield /
Formoterol Fumarate-013960303-94-0Formoterol Fumarate-014—Formoterol Fumarate-015—API · Formoterol Fumarate/Glycopyrrolate
| Code | CAS No. | Intermediate |
|---|---|---|
| Formoterol Fumarate-013 | 960303-94-0 | N-{5-[(1R)-2-amino-1-hydroxyethyl]-2-hydroxyphenyl}formamide |
| Formoterol Fumarate-014 | - | 1-(4-Methoxyphenyl)-2-propanone |
| Formoterol Fumarate-015 | - | 1,2-Ethylenedicarboxylic acid |
OptimisedRoute 3Steps 1 · Total yield 150mg(Formoterol Fumarate-017)
Formoterol Fumarate-016345288-55-3Formoterol Fumarate-017126587-93-7API · Formoterol Fumarate/Glycopyrrolate
| Code | CAS No. | Intermediate |
|---|---|---|
| Formoterol Fumarate-016 | 345288-55-3 | 1-[4-(Benzyloxy)-3-nitrophenyl]-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethanol |
| Formoterol Fumarate-017 | 126587-93-7 | N-[2-(Benzyloxy)-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide |
OptimisedRoute 4Steps 8 · Total yield 3.84g(Formoterol Fumarate (API))
Formoterol Fumarate-01843229-66-9Formoterol Fumarate-01943229-67-0Formoterol Fumarate-020—Formoterol Fumarate-021—Formoterol Fumarate-008—Formoterol Fumarate-007—Formoterol Fumarate-009—Formoterol Fumarate-011—Formoterol Fumarate-012—API · Formoterol Fumarate/Glycopyrrolate
| Code | CAS No. | Intermediate |
|---|---|---|
| Formoterol Fumarate-018 | 43229-66-9 | 2-[Benzyl[1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanone |
| Formoterol Fumarate-019 | 43229-67-0 | 2-[Benzyl[1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanol |
| Formoterol Fumarate-020 | - | 1-(4-Methoxyphenyl)-2-benzylaminopropane |
| Formoterol Fumarate-021 | - | 2-[4-(Benzyloxy)-3-nitrophenyl]oxirane |
| Formoterol Fumarate-008 | - | (1R*)-1-[3-Amino-4-(benzyloxy)phenyl]-2-[benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]ethanol |
| Formoterol Fumarate-007 | - | (1R*)-2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-[4-(benzyloxy)-3-nitrophenyl]ethanol |
| Formoterol Fumarate-009 | - | Acido formico |
| Formoterol Fumarate-011 | - | N-[5-[(1R*)-2-[Benzyl[(2R*)-1-(4-methoxyphenyl)propan-2-yl]amino]-1-hydroxyethyl]-2-(benzyloxy)phenyl]formamide |
| Formoterol Fumarate-012 | - | N-[2-Hydroxy-5-[1(R*)-hydroxy-2-[1(R*)-methyl-2-(4-methoxyphenyl)ethylamino]ethyl]phenyl]formamide |
OptimisedRoute 5Steps 3 · Total yield /
Formoterol Fumarate-022—Formoterol Fumarate-023—Formoterol Fumarate-024—Formoterol Fumarate-025—API · Formoterol Fumarate/Glycopyrrolate
| Code | CAS No. | Intermediate |
|---|---|---|
| Formoterol Fumarate-022 | - | - |
| Formoterol Fumarate-023 | - | - |
| Formoterol Fumarate-024 | - | - |
| Formoterol Fumarate-025 | - | - |
OptimisedRoute 6Steps 1 · Total yield /
Formoterol Fumarate-026—Formoterol Fumarate-027—API · Formoterol Fumarate/Glycopyrrolate
| Code | CAS No. | Intermediate |
|---|---|---|
| Formoterol Fumarate-026 | - | Anisole |
| Formoterol Fumarate-027 | - | 1-Chloro-4-methoxybenzene |
OptimisedRoute 1Steps 4 · Total yield /
(I)860865-1-a427-49-6(II)860865-1-a1246930-41-5(III)860865-1-a13220-33-2(IV)860865-1-a13118-11-1(V)860865-1-a—(VI)860865-1-a80-48-8API · Formoterol Fumarate/Glycopyrrolate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)860865-1-a | 427-49-6 | (+/-)-Cyclopentylmandelic acid |
| (II)860865-1-a | 1246930-41-5 | 2-Cyclopentyl-2-hydroxy-1-(1H-imidazol-1-yl)-2-phenylethanone |
| (III)860865-1-a | 13220-33-2 | 1-Methylpyrrolidin-3-ol |
| (IV)860865-1-a | 13118-11-1 | (1-Methylpyrrolidin-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate |
| (V)860865-1-a | - | (3R)-1-Methylpyrrolidin-3-yl (2S)-cyclopentyl(hydroxy)phenylacetate |
| (VI)860865-1-a | 80-48-8 | 4-Methylbenzenesulfonic acid methyl ester |
OptimisedRoute 2Steps 1 · Total yield /
(Ia)860865-2-a—(Ib)860865-2-a—API · Formoterol Fumarate/Glycopyrrolate
| Code | CAS No. | Intermediate |
|---|---|---|
| (Ia)860865-2-a | - | 3(R*)-[2(S*)-Cyclopentyl-2-hydroxy-2-phenylacetyloxy]-1,1-dimethylpyrrolidinium bromide |
| (Ib)860865-2-a | - | (3R)-3-[[(2S)-2-Cyclopentyl-2-hydroxy-2-phenylacetyl]oxy]-1,1-dimethylpyrrolidin-1-ium acetate |
Frequently asked questions
What are the approved indications of Formoterol Fumarate/Glycopyrrolate?
Approved indications include: Chronic obstructive pulmonary disease.
When does the Formoterol Fumarate/Glycopyrrolate patent expire?
No public expiry year is available for Formoterol Fumarate/Glycopyrrolate yet; this page updates once verified.
How many synthesis routes are recorded for Formoterol Fumarate/Glycopyrrolate?
8 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Formoterol Fumarate/Glycopyrrolate intermediates?
All intermediates in Formoterol Fumarate/Glycopyrrolate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Formoterol Fumarate/Glycopyrrolate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29