Ambroxol Hydrochloride

Tier C — Watch / trade

Boehringer Ingelheim

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：SCNA

Brand：Lasolvan, Mucosolvan, Lazolvan, Ponophen, Mucoangin, Mucosal-L, Mucosolvan-L

Indications (approved)：Anaesthesia, Pharyngitis, Respiratory disease, Bronchitis

Regional status

No progress

2012-12-01

Approved

2001-07-11

China

Approved

1998-01-01

Japan

Approved

1984-03-01

Synthetic routes & intermediates11 routes

Originator routes × 0Optimised (non-patent) × 11Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 5 · Total yield 14.7g(Ambroxol)

Ambroxol- 00127489-62-9,50910-54-8Ambroxol- 002118-48-9Ambroxol- 003—Ambroxol- 004—Ambroxol- 005552-89-6Ambroxol- 006—API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 001	27489-62-9,50910-54-8	trans-4-Aminocyclohexanol
Ambroxol- 002	118-48-9	2,4-Dihydro-1H-3,1-benzoxazine-2,4-dione
Ambroxol- 003	-	trans-2-Amino-N-(4-hydroxycyclohexyl)benzamide
Ambroxol- 004	-	trans-4-(2-Aminobenzylamino)cyclohexanol
Ambroxol- 005	552-89-6 Available	2-Nitrobenzaldehyde
Ambroxol- 006	-	trans-4-(2-Nitrophenylmethyleneamino)cyclohexanol

OptimisedRoute 2Steps 3 · Total yield 4.5g(Ambroxol)

Ambroxol- 00750910-55-9Ambroxol- 00850910-53-7Ambroxol- 00127489-62-9,50910-54-8API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 007	50910-55-9	2-Amino-3,5-dibromobenzaldehyde
Ambroxol- 008	50910-53-7	trans-4-(2-Amino-3,5-dibromobenzylideneamino)cyclohexanol
Ambroxol- 001	27489-62-9,50910-54-8	trans-4-Aminocyclohexanol

OptimisedRoute 3Steps 5 · Total yield 13g(Ambroxol)

Ambroxol- 009592-57-4Ambroxol- 010189081-97-8Ambroxol- 01186379-71-7Ambroxol- 012199472-97-4Ambroxol- 013199473-03-5Ambroxol- 01418683-91-5API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 009	592-57-4	1,3-Cyclohexadiene
Ambroxol- 010	189081-97-8	(1R,4R)-4-Chlorocyclohex-2-en-1-yl acetate
Ambroxol- 011	86379-71-7	2-(Aminomethyl)-4,6-dibromoaniline
Ambroxol- 012	199472-97-4	(1R,4R)-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohex-2-en-1-yl acetate
Ambroxol- 013	199473-03-5	(1R,4R)-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohex-2-en-1-ol
Ambroxol- 014	18683-91-5	2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine

OptimisedRoute 4Steps 2 · Total yield /

Ambroxol- 01562715-80-4Ambroxol- 01627489-62-9,50910-54-8Ambroxol- 017—API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 015	62715-80-4	N-Acetyl-N-(2,4,6-tribromophenyl)acetamide
Ambroxol- 016	27489-62-9,50910-54-8	trans-4-Aminocyclohexanol
Ambroxol- 017	-	N-Acetyl-N-(2,4-dibromo-6-[[(trans-4-hydroxycyclohexyl)amino]methyl]phenyl)acetamide

OptimisedRoute 5Steps 10 · Total yield 2.345g(Ambroxol)

Ambroxol- 018118-92-3Ambroxol- 019134-20-3Ambroxol- 020606-00-8Ambroxol- 02150739-76-9Ambroxol- 022105735-86-2Ambroxol- 02318683-91-5Ambroxol- 00750910-55-9Ambroxol- 00850910-53-7Ambroxol- 00127489-62-9,50910-54-8API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 018	118-92-3	Anthranilic acid
Ambroxol- 019	134-20-3	Methyl anthranilate
Ambroxol- 020	606-00-8	Methyl 2-amino-3,5-dibromobenzoate
Ambroxol- 021	50739-76-9	2-Amino-3,5-dibromobenzyl alcohol
Ambroxol- 022	105735-86-2	2-Amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzamide
Ambroxol- 023	18683-91-5	2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
Ambroxol- 007	50910-55-9	2-Amino-3,5-dibromobenzaldehyde
Ambroxol- 008	50910-53-7	trans-4-(2-Amino-3,5-dibromobenzylideneamino)cyclohexanol
Ambroxol- 001	27489-62-9,50910-54-8	trans-4-Aminocyclohexanol

OptimisedRoute 6Steps 5 · Total yield /

Ambroxol- 02465962-15-4Ambroxol- 0252719820-08-1Ambroxol- 0262719820-10-5Ambroxol- 027529-23-7Ambroxol- 02826908-34-9Ambroxol- 00750910-55-9API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 024	65962-15-4	1-(Dibromomethyl)-2-nitrobenzene
Ambroxol- 025	2719820-08-1	2-(Dibromomethyl)aniline
Ambroxol- 026	2719820-10-5	2,4-Dibromo-6-(dibromomethyl)aniline
Ambroxol- 027	529-23-7	2-Aminobenzaldehyde
Ambroxol- 028	26908-34-9	2-(1,3-Dioxolan-2-yl)aniline
Ambroxol- 007	50910-55-9	2-Amino-3,5-dibromobenzaldehyde

OptimisedRoute 7Steps 5 · Total yield 35.12g(Ambroxol)

Ambroxol- 029861787-48-6Ambroxol- 030—Ambroxol- 0312293093-91-9Ambroxol- 005552-89-6Ambroxol- 00127489-62-9,50910-54-8Ambroxol- 02318683-91-5API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 029	861787-48-6	3,5-Dibromo-2-nitrobenzaldehyde
Ambroxol- 030	-	trans-4-(2-Nitro-3,5-dibromobenzylideneamino)cyclohexanol
Ambroxol- 031	2293093-91-9	(2-Amino-3,5-dibromophenyl)methyl 1H-imidazole-1-carboxylate
Ambroxol- 005	552-89-6 Available	o-Nitrobenzaldehyde
Ambroxol- 001	27489-62-9,50910-54-8	trans-4-Aminocyclohexanol
Ambroxol- 023	18683-91-5	2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine

OptimisedRoute 8Steps 3 · Total yield 359.2g(Ambroxol)

Ambroxol- 03295-53-4Ambroxol- 033100669-81-6Ambroxol- 00127489-62-9,50910-54-8Ambroxol- 02318683-91-5API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 032	95-53-4	2-Methylaniline
Ambroxol- 033	100669-81-6	2,4-Dibromo-6-(bromomethyl)aniline
Ambroxol- 001	27489-62-9,50910-54-8	trans-4-Aminocyclohexanol
Ambroxol- 023	18683-91-5	2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine

OptimisedRoute 9Steps 3 · Total yield 10.9g(Ambroxol- 037)

Ambroxol- 03485-44-9Ambroxol- 03557-13-6Ambroxol- 03685-41-6Ambroxol- 037609-85-8Ambroxol- 018118-92-3API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 034	85-44-9 Available	2-Benzofuran-1,3-dione
Ambroxol- 035	57-13-6	Isourea
Ambroxol- 036	85-41-6	Phthalimide
Ambroxol- 037	609-85-8	3,5-Dibromo-2-aminobenzoic acid
Ambroxol- 018	118-92-3	2-Aminobenzoic acid

OptimisedRoute 10Steps 4 · Total yield 9.16g Ambroxol

Ambroxol- 038—Ambroxol- 022105735-86-2Ambroxol- 02318683-91-5Ambroxol- 00127489-62-9,50910-54-8Ambroxol- 002118-48-9API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 038	-	trans-2-Amino-N-(4-hydroxycyclohexyl)benzamide
Ambroxol- 022	105735-86-2	2-Amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzamide
Ambroxol- 023	18683-91-5	2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
Ambroxol- 001	27489-62-9,50910-54-8	trans-4-Aminocyclohexanol
Ambroxol- 002	118-48-9	Anthranilic acid N-carboxylic acid anhydride

OptimisedRoute 11Steps 4 · Total yield 14g(Ambroxol- 005)

Ambroxol- 03988-72-2Ambroxol- 0403958-60-9Ambroxol- 041612-25-9Ambroxol- 04286073-80-5Ambroxol- 005552-89-6API · Ambroxol Hydrochloride

Code	CAS No.	Intermediate
Ambroxol- 039	88-72-2	o-Nitrotoluene
Ambroxol- 040	3958-60-9	2-Nitrobenzyl bromide
Ambroxol- 041	612-25-9	(2-Nitrophenyl)methanol
Ambroxol- 042	86073-80-5	[4-(Carboxymethylidene)-2,2,6,6-tetramethylpiperidin-1-yl]oxidanyl
Ambroxol- 005	552-89-6 Available	o-Nitrobenzaldehyde

Frequently asked questions

What are the approved indications of Ambroxol Hydrochloride?

Approved indications include: Anaesthesia, Pharyngitis, Respiratory disease, Bronchitis.

When does the Ambroxol Hydrochloride patent expire?

No public expiry year is available for Ambroxol Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Ambroxol Hydrochloride?

11 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ambroxol Hydrochloride intermediates?

2 intermediate CAS of Ambroxol Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ambroxol Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29