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Fulvestrant
Tier B — Position earlyFulvestrant
AstraZeneca
Originator
2002
First approval
-
Expiry (public)
$1.03B ▲
Peak sales
Small molecule
Type
Targets：ERs
Brand：Faslodex
Indications (approved)：Breast cancer
Regional status
US
Approved
2002-04-25
EU
Approved
2004-03-09
China
Approved
2010-06-04
Japan
Approved
2011-09-26
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 12 · Total yield /
FULV-00155362-80-6FULV-002149051-24-1FULV-003875573-59-4FULV-0042590-41-2FULV-005875573-60-7FULV-006875573-64-1FULV-007—FULV-0081049661-87-1FULV-0091049661-86-0FULV-010—FULV-011—FULV-012148757-88-4FULV-013—FULV-014153004-31-0API · Fulvestrant
| Code | CAS No. | Intermediate |
|---|---|---|
| FULV-001 | 55362-80-6 | 9-bromononan-1-ol |
| FULV-002 | 149051-24-1 | ((9-bromononyl)oxy)(tert-butyl)dimethylsilane |
| FULV-003 | 875573-59-4 | (9-((tert-butyldimethylsilyl)oxy)nonyl)magnesium bromide |
| FULV-004 | 2590-41-2 | (8R,9S,10R,13S,14S,17S)-13-methyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate |
| FULV-005 | 875573-60-7 | (7R,8R,9S,10R,13S,14S,17S)-7-(9-((tert-butyldimethylsilyl)oxy)nonyl)-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate |
| FULV-006 | 875573-64-1 | (7R,8R,9S,10R,13S,14S,17S)-7-(9-hydroxynonyl)-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate |
| FULV-007 | - | 9-((7R,8R,9S,10R,13S,14S,17S)-17-acetoxy-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl)nonyl acetate |
| FULV-008 | 1049661-87-1 | 9-((7R,8R,9S,13S,14S,17S)-17-acetoxy-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)nonyl acetate |
| FULV-009 | 1049661-86-0 | (7R,8R,9S,13S,14S,17S)-3-hydroxy-7-(9-hydroxynonyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl acetate |
| FULV-010 | - | (7R,8R,9S,13S,14S,17S)-17-acetoxy-7-(9-hydroxynonyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl benzoate |
| FULV-011 | - | (7R,8R,9S,13S,14S,17S)-17-acetoxy-13-methyl-7-(9-((methylsulfonyl)oxy)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl benzoate |
| FULV-012 | 148757-88-4 | 4,4,5,5,5-pentafluoropentane-1-thiol |
| FULV-013 | - | (7R,8R,9S,13S,14S,17S)-17-acetoxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl benzoate |
| FULV-014 | 153004-31-0 | (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol |
OptimisedRoute 2Steps 7 · Total yield 2.35 g
FULV-014153004-31-0FULV-015434-22-0FULV-016571-92-6FULV-017116-11-0FULV-018486999-08-0FULV-0194549-33-1FULV-0201107606-65-4FULV-0211107606-66-5FULV-0221107606-68-7FULV-0231107606-67-6API · Fulvestrant
| Code | CAS No. | Intermediate |
|---|---|---|
| FULV-014 | 153004-31-0 | (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol |
| FULV-015 | 434-22-0 | (8R,9S,10R,13S,14S,17S)-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one |
| FULV-016 | 571-92-6 | (8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one |
| FULV-017 | 116-11-0 | 2-methoxyprop-1-ene |
| FULV-018 | 486999-08-0 | (8R,9S,13S,14S,17S)-3,17-bis((2-methoxypropan-2-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one |
| FULV-019 | 4549-33-1 | 1,9-dibromononane |
| FULV-020 | 1107606-65-4 | (7S,8R,9S,13S,14S,17S)-7-(9-bromononyl)-3,17-bis((2-methoxypropan-2-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one |
| FULV-021 | 1107606-66-5 | (7R,8R,9S,13S,14S,17S)-7-(9-bromononyl)-3,17-bis((2-methoxypropan-2-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene |
| FULV-022 | 1107606-68-7 | 4,4,5,5,5-pentafluoropentyl carbamimidothioate methanesulfonate |
| FULV-023 | 1107606-67-6 | (9-((7R,8R,9S,13S,14S,17S)-3,17-bis((2-methoxypropan-2-yl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)nonyl)(4,4,5,5,5-pentafluoropentyl)sulfane |
OptimisedRoute 3Steps 6 · Total yield 2.7 g
FULV-014153004-31-0FULV-024—FULV-025—FULV-026122566-22-7FULV-02753573-82-3FULV-028862700-63-8FULV-029862700-70-7API · Fulvestrant
| Code | CAS No. | Intermediate |
|---|---|---|
| FULV-014 | 153004-31-0 | (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol |
| FULV-024 | - | (8R,9S,13S,14S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol |
| FULV-025 | - | 2,2'-(((8R,9S,13S,14S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl)bis(oxy))bis(tetrahydro-2H-pyran) |
| FULV-026 | 122566-22-7 | (8R,9S,13S,14S,17S)-13-methyl-3,17-bis((tetrahydro-2H-pyran-2-yl)oxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-ol |
| FULV-027 | 53573-82-3 | (8R,9S,13S,14S,17S)-13-methyl-3,17-bis((tetrahydro-2H-pyran-2-yl)oxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one |
| FULV-028 | 862700-63-8 | (9-iodononyl)(4,4,5,5,5-pentafluoropentyl)sulfane |
| FULV-029 | 862700-70-7 | (7S,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-3,17-bis((tetrahydro-2H-pyran-2-yl)oxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one |
OptimisedRoute 4Steps 4 · Total yield 9.0 g
FULV-014153004-31-0FULV-0194549-33-1FULV-02753573-82-3FULV-029862700-70-7FULV-0301607427-00-8FULV-031862700-61-6API · Fulvestrant
| Code | CAS No. | Intermediate |
|---|---|---|
| FULV-014 | 153004-31-0 | (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol |
| FULV-019 | 4549-33-1 | 1,9-dibromononane |
| FULV-027 | 53573-82-3 | (8R,9S,13S,14S,17S)-13-methyl-3,17-bis((tetrahydro-2H-pyran-2-yl)oxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one |
| FULV-029 | 862700-70-7 | (7S,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-3,17-bis((tetrahydro-2H-pyran-2-yl)oxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one |
| FULV-030 | 1607427-00-8 | (7S,8R,9S,13S,14S,17S)-7-(9-bromononyl)-13-methyl-3,17-bis((tetrahydro-2H-pyran-2-yl)oxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one |
| FULV-031 | 862700-61-6 | S-(4,4,5,5,5-pentafluoropentyl) benzothioate |
OptimisedRoute 5Steps 5 · Total yield 12 g
FULV-014153004-31-0FULV-016571-92-6FULV-028862700-63-8FULV-0323434-45-5FULV-033—FULV-0341428484-17-6API · Fulvestrant
| Code | CAS No. | Intermediate |
|---|---|---|
| FULV-014 | 153004-31-0 | (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol |
| FULV-016 | 571-92-6 | (8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one |
| FULV-028 | 862700-63-8 | (9-iodononyl)(4,4,5,5,5-pentafluoropentyl)sulfane |
| FULV-032 | 3434-45-5 | (8R,9S,13S,14S,17S)-13-methyl-6-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl diacetate |
| FULV-033 | - | (7S,8R,9S,13S,14S,17S)-13-methyl-6-oxo-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl diacetate |
| FULV-034 | 1428484-17-6 | (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)thio)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl diacetate |
Frequently asked questions
What are the approved indications of Fulvestrant?
Approved indications include: Breast cancer.
When does the Fulvestrant patent expire?
No public expiry year is available for Fulvestrant yet; this page updates once verified.
How many synthesis routes are recorded for Fulvestrant?
5 synthesis routes are recorded; the shortest is 4 steps with 9.0 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Fulvestrant intermediates?
All intermediates in Fulvestrant routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Fulvestrant intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29