Drugs Losing Exclusivity in 2031 & Key Intermediates
9 drugs expire in 2031 (public sources), 8 with recorded synthesis routes; key intermediates of 8 drugs are already available through the Unibest supply network. Generic developers typically secure intermediate supply 2–3 years ahead — use this table for shortlisting and RFQ.
| Drug | Tier | Expiry | Indications | Routes | CAS count | Available |
|---|---|---|---|---|---|---|
| Osimertinib Mesylate | A · Act now | 2031 | Non-small cell lung cancer | 4 | 29 | Available ×29 |
| Vibegron | C · Watch | 2031 | Overactive bladder, Urinary incontinence | 2 | 22 | Available ×22 |
| Relugolix | C · Watch | 2031 | Prostate cancer, Leiomyoma | 1 | 12 | Available ×12 |
| Darolutamide | B · Position early | 2031 | Hormone-sensitive prostate cancer, Castration-sensitive prostate cancer, Prostate cancer | 1 | 9 | Available ×9 |
| Lumateperone tosylate | C · Watch | 2031 | Major depressive disorder, Depression, Schizophrenia | 1 | 9 | Available ×9 |
| Pralsetinib | C · Watch | 2031 | Non-small cell lung cancer, Thyroid cancer, Medullary thyroid cancer | 7 | 41 | Available ×4 |
| Zanubrutinib | A · Act now | 2031 | Waldenström macroglobulinaemia, Chronic lymphocytic leukaemia, Follicular lymphoma | 1 | 12 | Available ×2 |
| Lusutrombopag | C · Watch | 2031 | Thrombocytopenia | 1 | 12 | Available ×1 |
| Semaglutide | A · Act now | 2031 | Overweight, Obesity, Type 2 diabetes | - | - | - |
Frequently asked questions
Which drugs lose exclusivity in 2031?
9 drugs expire in 2031 per public sources: Osimertinib Mesylate, Zanubrutinib, Pralsetinib, Lumateperone tosylate, Darolutamide, Relugolix, etc.
When should we start sourcing intermediates for 2031 launches?
Generic developers typically secure development-scale supply 2–3 years before expiry. 8 of the 9 drugs in this table already have on-sale intermediates in the Unibest network; the rest can be RFQ'd per CAS.
Are route and CAS data verified?
All fields are structured data cross-verified from public sources; intermediates carry registry codes and CAS numbers, and every "Available" badge links to real listings.
Source: cross-verified structured fields · Expiry years are public-source estimates; consult individual agencies for authoritative dates · 2026-09-29