CAS 100-02-7

4-nitrophenol

Codes: CABO-013, PIOG-002

Application context (from source-drug indications)

Neuroendocrine tumourCabozantinib S-malatePancreatic neuroendocrine tumourCabozantinib S-malateRenal cell carcinomaCabozantinib S-malateHepatocellular carcinomaCabozantinib S-malateThyroid cancerCabozantinib S-malateNeuroendocrine carcinomaCabozantinib S-malateType 2 diabetesAlogliptin Benzoate/Pioglitazone HydrochlorideType 2 diabetesPioglitazone HydrochloridePulmonary hypertensionPioglitazone HydrochlorideBreast cancerPioglitazone HydrochlorideNon-alcoholic steatohepatitisPioglitazone HydrochlorideCocaine addictionPioglitazone HydrochlorideAlcohol abusePioglitazone Hydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Cabozantinib S-malate	Tier B — Position early	2029
Alogliptin Benzoate/Pioglitazone Hydrochloride	Tier C — Watch / trade	-
Pioglitazone Hydrochloride	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Cabozantinib S-malateProcess routesteps: 5total yield: 5.0 kg

ethyl formate→6,7-dimethoxyquinolin-4-ol→4-chloro-6,7-dimethoxyquinoline→4-nitrophenol→6,7-dimethoxy-4-(4-nitrophenoxy)quinoline→4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline→1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

Alogliptin Benzoate/Pioglitazone HydrochlorideOriginator routesteps: 5total yield: 20.50 g

2-(5-ethylpyridin-2-yl)ethan-1-ol→4-nitrophenol→5-ethyl-2-(2-(4-nitrophenoxy)ethyl)pyridine→4-(2-(5-ethylpyridin-2-yl)ethoxy)aniline→ethyl acrylate→ethyl 2-bromo-3-(4-(2-(5-ethylpyridin-2-yl)ethoxy)phenyl)propanoate→thiourea→5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)-4-iminothiazolidin-2-one

Pioglitazone HydrochlorideOriginator routesteps: 5total yield: 20.50 g

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-Hydroxy-6,7-dimethoxyqunioline Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	4-((6,7-Dimethoxyquinolin -4-yl)oxy)aniline Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.