CAS 100-48-1

isonicotinonitrile

Codes: TOPI-005, DALF-006, CLAZ-001

Application context (from source-drug indications)

HyperuricaemiaTopiroxostatGoutTopiroxostatDiabetic nephropathyTopiroxostatMultiple sclerosisDalfampridineSpinocerebellar ataxiaDalfampridineShort-term memory impairmentDalfampridineCrush injuryDalfampridinePeripheral nerve injuryDalfampridineSpinal cord injuryDalfampridine动脉瘤Clazosentan SodiumIntracranial vasospasmClazosentan SodiumSubarachnoid haemorrhageClazosentan SodiumCerebral infarctionClazosentan Sodium脑缺血Clazosentan Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Topiroxostat	Tier C — Watch / trade	-
Dalfampridine	Tier C — Watch / trade	-
Clazosentan Sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

TopiroxostatOriginator routesteps: 4total yield: 3.66 g

4-carboxypyridine 1-oxide→4-(methoxycarbonyl)pyridine 1-oxide→methyl 2-cyanoisonicotinate→2-cyanoisonicotinohydrazide→isonicotinonitrile

TopiroxostatOptimised routesteps: 4total yield: /

4-carboxypyridine 1-oxide→isonicotinonitrile→4-(2-(tert-butoxycarbonyl)hydrazinecarbonyl)pyridine 1-oxide→tert-butyl 2-(2-cyanoisonicotinoyl)hydrazinecarboxylate→2-cyanoisonicotinohydrazide

TopiroxostatOptimised routesteps: 4total yield: 19 g

methyl 2-cyanoisonicotinate→2-cyanoisonicotinohydrazide→isonicotinonitrile→methyl isonicotinate→methyl 2-carbamoylisonicotinate

DalfampridineOptimised routesteps: 1total yield: 8.2 g

isonicotinonitrile

Clazosentan SodiumOriginator routesteps: 8total yield: /

isonicotinonitrile→isonicotinimidamide hydrochloride→dimethyl 2-(2-methoxyphenoxy)malonate→5-(2-methoxyphenoxy)-2-(pyridin-4-yl)pyrimidine-4,6-diol→4,6-dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)pyrimidine→4-(4,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-2-yl)pyridine 1-oxide→potassium ((5-methylpyridin-2-yl)sulfonyl)amide→4-(4-chloro-5-(2-methoxyphenoxy)-6-((5-methylpyridine)-2-sulfonamido)pyrimidin-2-yl)pyridine 1-oxide→4-(4-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-6-((5-methylpyridine)-2-sulfonamido)pyrimidin-2-yl)pyridine 1-oxide→N-(2-(2-cyanopyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide

Intermediates available on this site

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