← Back to patent-cliff list
CAS 1001315-05-4
Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-(piperazin-1-yliminomethyl)-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester
Codes: Rifampicin-007
Application context (from source-drug indications)
Mycobacterium tuberculosis infectionEthambutol Hydrochloride/Rifampicin/IsoniazidMycobacterium tuberculosis infectionRifampicinMycobacterium leprae infectionRifampicinPulmonary tuberculosisRifampicinMeningococcal meningitisRifampicinCOVID-19RifampicinRespiratory viral infectionRifampicin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ethambutol Hydrochloride/Rifampicin/Isoniazid | Tier C — Watch / trade | - |
| Rifampicin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Ethambutol Hydrochloride/Rifampicin/IsoniazidOptimised routesteps: 4total yield: 572g([11C]rifampicin (FREE))
Piperazine→1-Nitrosopiperazine→1-Aminopiperazine→3-Formylrifamycin→Iodo[11C]methane→Trifluoromethanesulfonic acid [11C]methyl ester→Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-(piperazin-1-yliminomethyl)-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester→3-(4-[11C]Methylpiperazin-1-yliminomethyl)rifamycin
Piperazine→1-Nitrosopiperazine→1-Aminopiperazine→3-Formylrifamycin→Iodo[11C]methane→Trifluoromethanesulfonic acid [11C]methyl ester→Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-(piperazin-1-yliminomethyl)-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester→3-(4-[11C]Methylpiperazin-1-yliminomethyl)rifamycin
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.