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CAS 1004-75-7
2,5,6-Triaminopyrimidin-4(5H)-one
Codes: Folic Acid-014
Application context (from source-drug indications)
Essential hypertensionEnalapril Maleate/Folic AcidMegaloblastic anaemiaFolic AcidFolate deficiencyFolic AcidNeural tube defectFolic AcidAnaemiaFolic AcidHot flushesFolic AcidHyperhomocysteinaemiaFolic Acid
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
| Folic Acid | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,3-Dihydroxy-2-propenal→N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester→N-[4-[2,3-Dihydroxy-2-propenylideneamino]benzoyl]-L-glutamic acid diethyl diester→2,5,6-Triaminopyrimidin-4(5H)-one
N-(4-Aminobenzoyl)-L-glutamic acid→N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester→2,3-Dibromopropanal→N-[4-(2,3-Dibromopropylideneamino)benzoyl]-L-glutamic acid diethyl diester→2,5,6-Triaminopyrimidin-4(5H)-one→N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid diethyl diester
2,5,6-Triaminopyrimidin-4(5H)-one→N-(4-Aminobenzoyl)-L-glutamic acid→2,3-Dichloropropanal→2,3-Dibromopropanal
[1,3-13C]Propan-2-one→1,1,3-Trichloro[1,3-13C]propan-2-one→1,3-Dichloro[1,3-13C]propan-2-one→2,5,6-Triaminopyrimidin-4(5H)-one→N-(4-Aminobenzoyl)-L-glutamic acid→N-[[4-([[2-Amino-4-oxo[7-13C]-4,4a-dihydropteridin-6-yl][13C]methyl]amino)phenyl]carbonyl]-L-glutamic acid
4-Nitrobenzoyl chloride→(S)-(+)-Glutamic acid→(2S)-[(4-Nitrobenzoyl)amino]pentanedioic acid→Sodium 1-[[(1S)-1-carboxy-3-carboxylatopropyl]carbamoyl]-4-nitrobenzene→N-(4-Aminobenzoyl)-L-glutamic acid→2,5,6-Triaminopyrimidin-4(5H)-one→2,5,6-Triaminopyrimidin-4-one sulfate→1,1,3-Trichloroacetone
2-Cyanoacetic acid ethyl ester→Aminoformamidine hydrochloride→2,4-Diamino-6-hydroxypyrimidine→2,4-Diamino-6-hydroxy-5-nitrosopyrimidine→2,5,6-Triaminopyrimidin-4(5H)-one→2-Propenal→Methyl 4-aminobenzoate→Methyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzoate→L-Glutamic acid monosodium salt
2,3-Dihydroxy-2-propenal→N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester→N-[4-[2,3-Dihydroxy-2-propenylideneamino]benzoyl]-L-glutamic acid diethyl diester→2,5,6-Triaminopyrimidin-4(5H)-one
N-(4-Aminobenzoyl)-L-glutamic acid→N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester→2,3-Dibromopropanal→N-[4-(2,3-Dibromopropylideneamino)benzoyl]-L-glutamic acid diethyl diester→2,5,6-Triaminopyrimidin-4(5H)-one→N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid diethyl diester
2,5,6-Triaminopyrimidin-4(5H)-one→N-(4-Aminobenzoyl)-L-glutamic acid→2,3-Dichloropropanal→2,3-Dibromopropanal
[1,3-13C]Propan-2-one→1,1,3-Trichloro[1,3-13C]propan-2-one→1,3-Dichloro[1,3-13C]propan-2-one→2,5,6-Triaminopyrimidin-4(5H)-one→N-(4-Aminobenzoyl)-L-glutamic acid→N-[[4-([[2-Amino-4-oxo[7-13C]-4,4a-dihydropteridin-6-yl][13C]methyl]amino)phenyl]carbonyl]-L-glutamic acid
4-Nitrobenzoyl chloride→(S)-(+)-Glutamic acid→(2S)-[(4-Nitrobenzoyl)amino]pentanedioic acid→Sodium 1-[[(1S)-1-carboxy-3-carboxylatopropyl]carbamoyl]-4-nitrobenzene→N-(4-Aminobenzoyl)-L-glutamic acid→2,5,6-Triaminopyrimidin-4(5H)-one→2,5,6-Triaminopyrimidin-4-one sulfate→1,1,3-Trichloroacetone
2-Cyanoacetic acid ethyl ester→Aminoformamidine hydrochloride→2,4-Diamino-6-hydroxypyrimidine→2,4-Diamino-6-hydroxy-5-nitrosopyrimidine→2,5,6-Triaminopyrimidin-4(5H)-one→2-Propenal→Methyl 4-aminobenzoate→Methyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzoate→L-Glutamic acid monosodium salt
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