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CAS 1004316-38-4
tert-butyl benzyl((2S,5S)-5-((tert-butoxycarbonyl)amino)-3-hydroxy-1,6-diphenyl-4-(phenylsulfonyl)hexan-2-yl)carbamate
Codes: COBI-010
Application context (from source-drug indications)
HIV infectionCobicistatNon-small cell lung cancerCobicistatAcquired immunodeficiency syndromeCobicistat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Cobicistat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(2-isopropylthiazol-4-yl)-N-methylmethanamine→(S)-methyl 2-amino-4-((tert-butoxycarbonyl)amino)butanoate hydrochloride→(S)-methyl 4-((tert-butoxycarbonyl)amino)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate→(S)-4-((tert-butoxycarbonyl)amino)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoic acid→thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate→COBI-006→thiazol-5-ylmethyl ((2R,5R)-5-((S)-4-amino-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanamido)-1,6-diphenylhexan-2-yl)carbamate→(S)-tert-butyl (1-phenyl-3-(phenylsulfonyl)propan-2-yl)carbamate→(S)-tert-butyl benzyl(1-oxo-3-phenylpropan-2-yl)carbamate→tert-butyl benzyl((2S,5S)-5-((tert-butoxycarbonyl)amino)-3-hydroxy-1,6-diphenyl-4-(phenylsulfonyl)hexan-2-yl)carbamate→tert-butyl benzyl((2S,5S,E)-5-((tert-butoxycarbonyl)amino)-1,6-diphenylhex-3-en-2-yl)carbamate→di-tert-butyl ((2S,5S,E)-1,6-diphenylhex-3-ene-2,5-diyl)dicarbamate→(2R,5R)-1,6-diphenylhexane-2,5-diamine→4-nitrophenyl (thiazol-5-ylmethyl) carbonate
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