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CAS 1012078-88-4
methyl (6S)-7-(1,1-difluoroethyl)-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylate
Codes: VINF-009
Application context (from source-drug indications)
Urinary tract neoplasmVinflunine DitartrateUrothelial carcinomaVinflunine DitartrateBreast cancerVinflunine DitartrateLung cancerVinflunine DitartrateGastric cancerVinflunine DitartratePenile cancerVinflunine Ditartrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Vinflunine Ditartrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl (6S)-7-ethyl-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylate→dimethyl (6S)-7-ethyl-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→dimethyl (6S)-7-ethyl-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→dimethyl (6S)-7-(1-hydroxyethyl)-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→dimethyl (6S)-7-acetyl-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→dimethyl (6S)-7-(1,1-difluoroethyl)-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-5,6(6aH)-dicarboxylate→methyl (6S)-7-(1,1-difluoroethyl)-10-oxo-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylate→methyl (6S)-7-(1,1-difluoroethyl)-9,10,12,13-tetrahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylate
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