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CAS 1012879-09-2
(2-Bromo-4-fluoro-5-nitrophenyl)acetic acid
Codes: (XIV)819703-1-a, (I)819703-3-a
Application context (from source-drug indications)
Gastrointestinal stromal tumourRipretinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ripretinib | Tier C — Watch / trade | 2032 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,3-Acetonedicarboxylic acid diethyl ester→4,6-Dihydroxynicotinic acid ethyl ester→2,4-Dichloro-5-carbethoxypyridine→Aminoethane→6-Chloro-4-ethylamino-nicotinic acid ethyl ester→[6-Chloro-4-(ethylamino)pyridin-3-yl]methanol→6-Chloro-4-(ethylamino)nicotinaldehyde→Ethyl (5-amino-2-bromo-4-fluorophenyl)acetate→3-(5-Amino-2-bromo-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one→Aminomethane→3-(5-Amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one→3-(5-Amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one hydrochloride→4-Isocyanatobenzene→Carbanilic acid phenyl ester→2-(2-Bromo-4-fluorophenyl)acetic acid→(2-Bromo-4-fluoro-5-nitrophenyl)acetic acid→Ethyl (2-bromo-4-fluoro-5-nitrophenyl)acetate
(2-Bromo-4-fluoro-5-nitrophenyl)acetic acid→Carbanilic acid phenyl ester→Ethyl [2-bromo-4-fluoro-5-[(phenylcarbamoyl)amino]phenyl]acetate→6-Chloro-4-(ethylamino)nicotinaldehyde→N-[4-Bromo-5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→Aminomethane
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